Diagnostic accuracy of lugol chromoendoscopy in the oesophagus in patients with head and neck cancer Seguridad diagnóstica de la cromoendoscopia con lugol en el esófago de pacientes con cáncer de cabeza y cuello
Background and aim: patients with head and neck squamous cell malignancies have a higher risk of oesophageal squamous cell carcinomas. Lugol chromoendoscopy in oesophagus is a simple technique with a high diagnostic yield in premalignant lesions. The objective was to analyze its diagnostic accuracy...
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| Format: | Article |
| Language: | English |
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Aran Ediciones
2013-02-01
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| Series: | Revista Espanola de Enfermedades Digestivas |
| Subjects: | |
| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082013000200004 |
| _version_ | 1818577689716457472 |
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| author | Rita Carvalho Miguel Areia Daniel Brito Sandra Saraiva Susana Alves Ana Teresa Cadime |
| author_facet | Rita Carvalho Miguel Areia Daniel Brito Sandra Saraiva Susana Alves Ana Teresa Cadime |
| author_sort | Rita Carvalho |
| collection | DOAJ |
| description | Background and aim: patients with head and neck squamous cell malignancies have a higher risk of oesophageal squamous cell carcinomas. Lugol chromoendoscopy in oesophagus is a simple technique with a high diagnostic yield in premalignant lesions. The objective was to analyze its diagnostic accuracy in dysplasia and carcinoma of the oesophagus in high-risk patients. Methods: prospective study from April/2008 to January/2012 using lugol chromoendoscopy with biopsies of suspicious lugol voiding areas ≥ 5 mm. Patients with head and neck malignancies were included, except the ones with iodine allergy, oesophageal varices and contra-indications to standard endoscopy. The reference method was histopathology. Results: 89 patients were enrolled (mean age 62.8 ± 13.3 years, 87 % men). Primary tumour was located in oropharynx in 37 (41.6 %), in oral cavity in 29 (32.6 %) and in the larynx in 23 (25.8 %) cases. 40.4 % patients had previous treatments and 87 % reported alcohol or tobacco addition. All exams performed without anaesthesia or complications. Nine suspicious lugol voiding areas were observed and biopsied. Histopathological analysis revealed high-grade dysplasia in 2 (2.2 %) and inflammation or normal findings in the others. The sensitivity and specificity for detecting high-grade dysplasia were 100 % and 92 % (95 % CI: 87-97), respectively. Diagnostic accuracy of the test was 92 % (95 % CI: 86-98). Conclusion: lugol staining of the oesophagus during endoscopy seems to be a feasible, safe and justified procedure in high-risk population as it enhances the detection of premalignant lesions. |
| first_indexed | 2024-12-16T06:33:55Z |
| format | Article |
| id | doaj.art-0334648cf7ed403bb5580b6ff66f24df |
| institution | Directory Open Access Journal |
| issn | 1130-0108 |
| language | English |
| last_indexed | 2024-12-16T06:33:55Z |
| publishDate | 2013-02-01 |
| publisher | Aran Ediciones |
| record_format | Article |
| series | Revista Espanola de Enfermedades Digestivas |
| spelling | doaj.art-0334648cf7ed403bb5580b6ff66f24df2022-12-21T22:40:50ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-01082013-02-0110527983Diagnostic accuracy of lugol chromoendoscopy in the oesophagus in patients with head and neck cancer Seguridad diagnóstica de la cromoendoscopia con lugol en el esófago de pacientes con cáncer de cabeza y cuelloRita CarvalhoMiguel AreiaDaniel BritoSandra SaraivaSusana AlvesAna Teresa CadimeBackground and aim: patients with head and neck squamous cell malignancies have a higher risk of oesophageal squamous cell carcinomas. Lugol chromoendoscopy in oesophagus is a simple technique with a high diagnostic yield in premalignant lesions. The objective was to analyze its diagnostic accuracy in dysplasia and carcinoma of the oesophagus in high-risk patients. Methods: prospective study from April/2008 to January/2012 using lugol chromoendoscopy with biopsies of suspicious lugol voiding areas ≥ 5 mm. Patients with head and neck malignancies were included, except the ones with iodine allergy, oesophageal varices and contra-indications to standard endoscopy. The reference method was histopathology. Results: 89 patients were enrolled (mean age 62.8 ± 13.3 years, 87 % men). Primary tumour was located in oropharynx in 37 (41.6 %), in oral cavity in 29 (32.6 %) and in the larynx in 23 (25.8 %) cases. 40.4 % patients had previous treatments and 87 % reported alcohol or tobacco addition. All exams performed without anaesthesia or complications. Nine suspicious lugol voiding areas were observed and biopsied. Histopathological analysis revealed high-grade dysplasia in 2 (2.2 %) and inflammation or normal findings in the others. The sensitivity and specificity for detecting high-grade dysplasia were 100 % and 92 % (95 % CI: 87-97), respectively. Diagnostic accuracy of the test was 92 % (95 % CI: 86-98). Conclusion: lugol staining of the oesophagus during endoscopy seems to be a feasible, safe and justified procedure in high-risk population as it enhances the detection of premalignant lesions.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082013000200004Oesophageal cancerSquamous cell carcinomaLugol solutionGastrointestinal EndoscopyChromoendoscopy |
| spellingShingle | Rita Carvalho Miguel Areia Daniel Brito Sandra Saraiva Susana Alves Ana Teresa Cadime Diagnostic accuracy of lugol chromoendoscopy in the oesophagus in patients with head and neck cancer Seguridad diagnóstica de la cromoendoscopia con lugol en el esófago de pacientes con cáncer de cabeza y cuello Revista Espanola de Enfermedades Digestivas Oesophageal cancer Squamous cell carcinoma Lugol solution Gastrointestinal Endoscopy Chromoendoscopy |
| title | Diagnostic accuracy of lugol chromoendoscopy in the oesophagus in patients with head and neck cancer Seguridad diagnóstica de la cromoendoscopia con lugol en el esófago de pacientes con cáncer de cabeza y cuello |
| title_full | Diagnostic accuracy of lugol chromoendoscopy in the oesophagus in patients with head and neck cancer Seguridad diagnóstica de la cromoendoscopia con lugol en el esófago de pacientes con cáncer de cabeza y cuello |
| title_fullStr | Diagnostic accuracy of lugol chromoendoscopy in the oesophagus in patients with head and neck cancer Seguridad diagnóstica de la cromoendoscopia con lugol en el esófago de pacientes con cáncer de cabeza y cuello |
| title_full_unstemmed | Diagnostic accuracy of lugol chromoendoscopy in the oesophagus in patients with head and neck cancer Seguridad diagnóstica de la cromoendoscopia con lugol en el esófago de pacientes con cáncer de cabeza y cuello |
| title_short | Diagnostic accuracy of lugol chromoendoscopy in the oesophagus in patients with head and neck cancer Seguridad diagnóstica de la cromoendoscopia con lugol en el esófago de pacientes con cáncer de cabeza y cuello |
| title_sort | diagnostic accuracy of lugol chromoendoscopy in the oesophagus in patients with head and neck cancer seguridad diagnostica de la cromoendoscopia con lugol en el esofago de pacientes con cancer de cabeza y cuello |
| topic | Oesophageal cancer Squamous cell carcinoma Lugol solution Gastrointestinal Endoscopy Chromoendoscopy |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082013000200004 |
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