A Clinicopathological Study of Paediatric Liver Tumours in a Tertiary Care Hospital
Introduction: Paediatric primary liver tumours are the third largest group of solid abdominal neoplasms in children next to neuroblastoma and Wilms tumour, accounting for about 0.5% to 2% of all paediatric neoplasms, in which hepatoblastoma is the most common. Aim: The present study was done to...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9592/24223_CE[Ra1]_F(DK)_PF1(Vg_Sy_Sh)_PFA(NC)_PF2(RB_SS).pdf |
| Summary: | Introduction: Paediatric primary liver tumours are the third
largest group of solid abdominal neoplasms in children next to
neuroblastoma and Wilms tumour, accounting for about 0.5%
to 2% of all paediatric neoplasms, in which hepatoblastoma is
the most common.
Aim: The present study was done to estimate the incidence of
paediatric liver tumours over a period of five years and also, to
study the clinical behaviour, alpha-fetoprotein correlation and
histopathological features of paediatric liver tumours.
Materials and Methods: The details of patients treated
for paediatric liver tumours for a period of five years were
retrospectively retrieved from the tumour board and medical
records. The gross features and all the slides were reviewed and
the pathologic diagnosis was confirmed and clinicopathological
correlation was then done.
Results: A total of 39 paediatric liver tumours were detected
during five years, of which 32 (82%) were malignant and
seven (18%) were benign with a male to female ratio of 1:1.1.
Hepatoblastoma was the most common liver tumour accounting
for 28 cases (71.8%), of which 25 cases (89.4%) were of pure
epithelial type. The second most common primary tumour was
epithelioid haemangioendothelioma with six cases (15.4%)
with female preponderance, followed by two cases each of
hepatocellular carcinoma and undifferentiated embryonal
sarcoma and one case of hepatocellular adenoma. Serum AFP
level was increased in hepatoblastoma and in hepatocellular
carcinoma, normal in hepatocellular adenoma and embryonal
sarcoma. Serum AFP level was increased in few cases of
epithelioid haemangioendothelioma.
Conclusion: The spectrum of liver tumours in children is
different from that in the adults. Hepatoblastoma is the most
common paediatric liver tumour, followed by epithelioid
haemangioendothelioma. Through better understanding of
pathological diagnosis, refined surgical staging, newer and more
effective radiological techniques and standardized multimodal
therapies, a substantial number of children diagnosed with this
highly malignant tumour can expect to survive the disease. |
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| ISSN: | 2249-782X 0973-709X |