Pubertal exposure to dietary advanced glycation end products disrupts ductal morphogenesis and induces atypical hyperplasia in the mammary gland

Pubertal exposure to dietary advanced glycation end products disrupts ductal morphogenesis and induces atypical hyperplasia in the mammary gland

Abstract Background Advanced glycation end products (AGEs) are reactive metabolites intrinsically linked with modern dietary patterns. Processed foods, and those high in sugar, protein and fat, often contain high levels of AGEs. Increased AGE levels are associated with increased breast cancer risk,...

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Bibliographic Details
Main Authors: Bradley A. Krisanits, Reid Schuster, Jaime Randise, Lourdes M. Nogueira, Jackson T. Lane, Gowtami A. Panguluri, Hong Li, Kristi Helke, Maria C. Cuitiño, Christopher Koivisto, Laura Spruill, Michael C. Ostrowski, Steven M. Anderson, David P. Turner, Victoria J. Findlay
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Breast Cancer Research
Subjects:
Advanced glycation end products
RAGE
Mammary gland development
Puberty
Diet
Microenvironment
Online Access:https://doi.org/10.1186/s13058-023-01714-4

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