Synthesis, Antibacterial and Antifungal Activities for Novel Derivatives of 2,2'-(((1-benzylbenzoimidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol)
The compound 2,2'-(((1H-benzo(d)imidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) was reacted with benzyl bromide to afford compound (1) which used as row material to prepare a series of compounds through condensation reaction, the starting compound were reacted with tosyl chloride to protect the...
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| Format: | Article |
| Language: | English |
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University of Baghdad
2019-01-01
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| Series: | Ibn Al-Haitham Journal for Pure and Applied Sciences |
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| Online Access: | https://jih.uobaghdad.edu.iq/index.php/j/article/view/1966 |
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| author | Aziz Latif Jarallah Khalid Fahad Ali Raied Mustafa Shakir Shaimaa Abed Saoud |
| author_facet | Aziz Latif Jarallah Khalid Fahad Ali Raied Mustafa Shakir Shaimaa Abed Saoud |
| author_sort | Aziz Latif Jarallah |
| collection | DOAJ |
| description |
The compound 2,2'-(((1H-benzo(d)imidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) was reacted with benzyl bromide to afford compound (1) which used as row material to prepare a series of compounds through condensation reaction, the starting compound were reacted with tosyl chloride to protect the OH group to afford compound 2, then reacted benzyl bromide to produce compound (2), then the compound (2) treated with three compounds ( 2-mercaptobenzthiazole, 2-mercaptobenimidazol and 2-chloromethyl benzimidazole) to form compounds 3a,b, 4a,b and 5a,b respectively. In the another step the click reaction of compound 2,2'-(((1H-benzo(d)imidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) with Propargyl bromide produce compound 6 which reacted with sodium azide or benzyl azide to afford the compounds 7 and 8. The synthesized compounds were characterized and measured the physical properties via the FT-IR, HNMR, besides to the CHN analysis. These newly compounds were screened their antibacterial and antifungal activity. Compounds 1, 2a and 8 showed significant antibacterial activity as well these compounds exhibited either low or moderated antifungal activity.
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| first_indexed | 2024-12-12T20:43:32Z |
| format | Article |
| id | doaj.art-0338b9968b8240d7b3375e380f8f1538 |
| institution | Directory Open Access Journal |
| issn | 1609-4042 2521-3407 |
| language | English |
| last_indexed | 2024-12-12T20:43:32Z |
| publishDate | 2019-01-01 |
| publisher | University of Baghdad |
| record_format | Article |
| series | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| spelling | doaj.art-0338b9968b8240d7b3375e380f8f15382022-12-22T00:12:39ZengUniversity of BaghdadIbn Al-Haitham Journal for Pure and Applied Sciences1609-40422521-34072019-01-0132110.30526/32.1.1966Synthesis, Antibacterial and Antifungal Activities for Novel Derivatives of 2,2'-(((1-benzylbenzoimidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol)Aziz Latif Jarallah0Khalid Fahad AliRaied Mustafa ShakirShaimaa Abed SaoudAL Zuhairy The compound 2,2'-(((1H-benzo(d)imidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) was reacted with benzyl bromide to afford compound (1) which used as row material to prepare a series of compounds through condensation reaction, the starting compound were reacted with tosyl chloride to protect the OH group to afford compound 2, then reacted benzyl bromide to produce compound (2), then the compound (2) treated with three compounds ( 2-mercaptobenzthiazole, 2-mercaptobenimidazol and 2-chloromethyl benzimidazole) to form compounds 3a,b, 4a,b and 5a,b respectively. In the another step the click reaction of compound 2,2'-(((1H-benzo(d)imidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) with Propargyl bromide produce compound 6 which reacted with sodium azide or benzyl azide to afford the compounds 7 and 8. The synthesized compounds were characterized and measured the physical properties via the FT-IR, HNMR, besides to the CHN analysis. These newly compounds were screened their antibacterial and antifungal activity. Compounds 1, 2a and 8 showed significant antibacterial activity as well these compounds exhibited either low or moderated antifungal activity. https://jih.uobaghdad.edu.iq/index.php/j/article/view/1966Benzimidazole, diethanolamine, Benzothiazole, Triazole, Antibacterial, Antifungal |
| spellingShingle | Aziz Latif Jarallah Khalid Fahad Ali Raied Mustafa Shakir Shaimaa Abed Saoud Synthesis, Antibacterial and Antifungal Activities for Novel Derivatives of 2,2'-(((1-benzylbenzoimidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) Ibn Al-Haitham Journal for Pure and Applied Sciences Benzimidazole, diethanolamine, Benzothiazole, Triazole, Antibacterial, Antifungal |
| title | Synthesis, Antibacterial and Antifungal Activities for Novel Derivatives of 2,2'-(((1-benzylbenzoimidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) |
| title_full | Synthesis, Antibacterial and Antifungal Activities for Novel Derivatives of 2,2'-(((1-benzylbenzoimidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) |
| title_fullStr | Synthesis, Antibacterial and Antifungal Activities for Novel Derivatives of 2,2'-(((1-benzylbenzoimidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) |
| title_full_unstemmed | Synthesis, Antibacterial and Antifungal Activities for Novel Derivatives of 2,2'-(((1-benzylbenzoimidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) |
| title_short | Synthesis, Antibacterial and Antifungal Activities for Novel Derivatives of 2,2'-(((1-benzylbenzoimidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) |
| title_sort | synthesis antibacterial and antifungal activities for novel derivatives of 2 2 1 benzylbenzoimidazol 2 yl methyl azanediyl bis ethan 1 ol |
| topic | Benzimidazole, diethanolamine, Benzothiazole, Triazole, Antibacterial, Antifungal |
| url | https://jih.uobaghdad.edu.iq/index.php/j/article/view/1966 |
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