PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study
Acute myocardial infarction (MI) is one of the most common causes of death worldwide. Pituitary adenylate cyclase activating polypeptide (PACAP) is a cardioprotective neuropeptide expressing its receptors in the cardiovascular system. The aim of our study was to examine tissue PACAP-38 in a translat...
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2021-03-01
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author | Dora Szabo Zsolt Sarszegi Beata Polgar Eva Saghy Adam Nemeth Dora Reglodi Andras Makkos Aniko Gorbe Zsuzsanna Helyes Peter Ferdinandy Robert Herczeg Attila Gyenesei Attila Cziraki Andrea Tamas |
author_facet | Dora Szabo Zsolt Sarszegi Beata Polgar Eva Saghy Adam Nemeth Dora Reglodi Andras Makkos Aniko Gorbe Zsuzsanna Helyes Peter Ferdinandy Robert Herczeg Attila Gyenesei Attila Cziraki Andrea Tamas |
author_sort | Dora Szabo |
collection | DOAJ |
description | Acute myocardial infarction (MI) is one of the most common causes of death worldwide. Pituitary adenylate cyclase activating polypeptide (PACAP) is a cardioprotective neuropeptide expressing its receptors in the cardiovascular system. The aim of our study was to examine tissue PACAP-38 in a translational porcine MI model and plasma PACAP-38 levels in patients with ST-segment elevation myocardial infarction (STEMI). Significantly lower PACAP-38 levels were detected in the non-ischemic region of the left ventricle (LV) in MI heart compared to the ischemic region of MI-LV and also to the Sham-operated LV in porcine MI model. In STEMI patients, plasma PACAP-38 level was significantly higher before percutaneous coronary intervention (PCI) compared to controls, and decreased after PCI. Significant negative correlation was found between plasma PACAP-38 and troponin levels. Furthermore, a significant effect was revealed between plasma PACAP-38, hypertension and HbA1c levels. This was the first study showing significant changes in cardiac tissue PACAP levels in a porcine MI model and plasma PACAP levels in STEMI patients. These results suggest that PACAP, due to its cardioprotective effects, may play a regulatory role in MI and could be a potential biomarker or drug target in MI. |
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issn | 1661-6596 1422-0067 |
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spelling | doaj.art-033c3086fe4a49c89d8f9fba3cad9c1d2023-11-21T10:14:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01226288310.3390/ijms22062883PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational StudyDora Szabo0Zsolt Sarszegi1Beata Polgar2Eva Saghy3Adam Nemeth4Dora Reglodi5Andras Makkos6Aniko Gorbe7Zsuzsanna Helyes8Peter Ferdinandy9Robert Herczeg10Attila Gyenesei11Attila Cziraki12Andrea Tamas13Heart Institute, Medical School, University of Pecs, 7624 Pecs, HungaryHeart Institute, Medical School, University of Pecs, 7624 Pecs, HungaryDepartment of Medical Microbiology and Immunology, Medical School, University of Pecs, 7624 Pecs, HungaryMTA-SE System Pharmacology Research Group and Cardiovascular and Metabolic Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, HungaryHeart Institute, Medical School, University of Pecs, 7624 Pecs, HungaryDepartment of Anatomy, MTA-PTE PACAP Research Team, Centre for Neuroscience, Medical School, University of Pecs, 7624 Pecs, HungaryMTA-SE System Pharmacology Research Group and Cardiovascular and Metabolic Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, HungaryMTA-SE System Pharmacology Research Group and Cardiovascular and Metabolic Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, HungaryDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pecs, 7624 Pecs, HungaryMTA-SE System Pharmacology Research Group and Cardiovascular and Metabolic Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, HungarySzentagothai Research Centre, University of Pecs, 7624 Pecs, HungarySzentagothai Research Centre, University of Pecs, 7624 Pecs, HungaryHeart Institute, Medical School, University of Pecs, 7624 Pecs, HungaryDepartment of Anatomy, MTA-PTE PACAP Research Team, Centre for Neuroscience, Medical School, University of Pecs, 7624 Pecs, HungaryAcute myocardial infarction (MI) is one of the most common causes of death worldwide. Pituitary adenylate cyclase activating polypeptide (PACAP) is a cardioprotective neuropeptide expressing its receptors in the cardiovascular system. The aim of our study was to examine tissue PACAP-38 in a translational porcine MI model and plasma PACAP-38 levels in patients with ST-segment elevation myocardial infarction (STEMI). Significantly lower PACAP-38 levels were detected in the non-ischemic region of the left ventricle (LV) in MI heart compared to the ischemic region of MI-LV and also to the Sham-operated LV in porcine MI model. In STEMI patients, plasma PACAP-38 level was significantly higher before percutaneous coronary intervention (PCI) compared to controls, and decreased after PCI. Significant negative correlation was found between plasma PACAP-38 and troponin levels. Furthermore, a significant effect was revealed between plasma PACAP-38, hypertension and HbA1c levels. This was the first study showing significant changes in cardiac tissue PACAP levels in a porcine MI model and plasma PACAP levels in STEMI patients. These results suggest that PACAP, due to its cardioprotective effects, may play a regulatory role in MI and could be a potential biomarker or drug target in MI.https://www.mdpi.com/1422-0067/22/6/2883pituitary adenylate cyclase activating polypeptideacute myocardial infarctionELISAclosed-chest myocardial infarction modelSTEMIcardioprotection |
spellingShingle | Dora Szabo Zsolt Sarszegi Beata Polgar Eva Saghy Adam Nemeth Dora Reglodi Andras Makkos Aniko Gorbe Zsuzsanna Helyes Peter Ferdinandy Robert Herczeg Attila Gyenesei Attila Cziraki Andrea Tamas PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study International Journal of Molecular Sciences pituitary adenylate cyclase activating polypeptide acute myocardial infarction ELISA closed-chest myocardial infarction model STEMI cardioprotection |
title | PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study |
title_full | PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study |
title_fullStr | PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study |
title_full_unstemmed | PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study |
title_short | PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study |
title_sort | pacap 38 in acute st segment elevation myocardial infarction in humans and pigs a translational study |
topic | pituitary adenylate cyclase activating polypeptide acute myocardial infarction ELISA closed-chest myocardial infarction model STEMI cardioprotection |
url | https://www.mdpi.com/1422-0067/22/6/2883 |
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