The Adipokine Profile and the Cardiometabolic Risk in Non-Obese Young Adults
Background: Young, non-obese adults are considered at low risk for cardiometabolic diseases, although markers of an unhealthy metabolic state are not uncommon findings in this population. Adipose tissue dysfunction, evaluated by the adipokine profile, significantly influences lipid and glucose metab...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2019-05-01
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| Series: | Balkan Medical Journal |
| Subjects: | |
| Online Access: | http://balkanmedicaljournal.org/text.php?lang=en&id=2062 |
| _version_ | 1797922571949178880 |
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| author | Marina Ruxandra Otelea Adrian Streinu-Cercel Cristian Băicus Maria Nitescu |
| author_facet | Marina Ruxandra Otelea Adrian Streinu-Cercel Cristian Băicus Maria Nitescu |
| author_sort | Marina Ruxandra Otelea |
| collection | DOAJ |
| description | Background: Young, non-obese adults are considered at low risk for cardiometabolic diseases, although markers of an unhealthy metabolic state are not uncommon findings in this population. Adipose tissue dysfunction, evaluated by the adipokine profile, significantly influences lipid and glucose metabolism and low-grade systemic inflammation.
Aims: To determine the relation between adipose tissue dysfunction and the already confirmed cardiometabolic risk indicators, including the atherogenic index of plasma, lipid accumulation product, homeostatic model assessment of insulin resistance, and the low-grade inflammation markers, namely, interleukin 6 and high-sensitivity C-reactive protein.
Study Design: Cross-sectional study.
Methods: We recruited 93 non-obese, healthy young adults. Anthropometric, lipid profile, inflammatory markers, and adipokines were measured. An abnormal adipokine profile (high leptin-to-adiponectin ratio) was considered as a marker of a dysfunctional adipose tissue. The correlation between the leptin-to-adiponectin ratio and the anthropometric measurements, atherogenic index of plasma, lipid accumulation product, homeostatic model assessment of insulin resistance, interleukin 6, and high-sensitivity C-reactive protein was determined.
Results: We found a direct correlation between the abnormal adipokine profile and the cardiometabolic risk indicators mentioned above, except for the low-grade inflammatory markers. In the regression model derived from our data, the leptin-to-adiponectin ratio was best correlated with the unfavorable plasma lipid profile, as estimated by the atherogenic index of plasma (r=0.097, confidence interval=0.015-0.180, p=0.021). A significantly higher leptin-to-adiponectin ratio was found in the insulin-resistant group (p=0.012) and in the highest lipid accumulation product quartile (p=0.032).
Conclusion: In a non-obese young population, the high rate of leptin-adiponectin may be a good predictor of cardiovascular and metabolic risk assessment. |
| first_indexed | 2024-04-10T14:34:30Z |
| format | Article |
| id | doaj.art-033d370207404216942dcd6c81dc2c5d |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T14:34:30Z |
| publishDate | 2019-05-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-033d370207404216942dcd6c81dc2c5d2023-02-15T16:08:40ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312019-05-0136315516110.4274/balkanmedj.galenos.2018.2018.0789The Adipokine Profile and the Cardiometabolic Risk in Non-Obese Young AdultsMarina Ruxandra Otelea0Adrian Streinu-Cercel1Cristian Băicus2Maria Nitescu3Carol Davila University of Medicine and Pharmacy, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Bucharest, RomaniaBackground: Young, non-obese adults are considered at low risk for cardiometabolic diseases, although markers of an unhealthy metabolic state are not uncommon findings in this population. Adipose tissue dysfunction, evaluated by the adipokine profile, significantly influences lipid and glucose metabolism and low-grade systemic inflammation. Aims: To determine the relation between adipose tissue dysfunction and the already confirmed cardiometabolic risk indicators, including the atherogenic index of plasma, lipid accumulation product, homeostatic model assessment of insulin resistance, and the low-grade inflammation markers, namely, interleukin 6 and high-sensitivity C-reactive protein. Study Design: Cross-sectional study. Methods: We recruited 93 non-obese, healthy young adults. Anthropometric, lipid profile, inflammatory markers, and adipokines were measured. An abnormal adipokine profile (high leptin-to-adiponectin ratio) was considered as a marker of a dysfunctional adipose tissue. The correlation between the leptin-to-adiponectin ratio and the anthropometric measurements, atherogenic index of plasma, lipid accumulation product, homeostatic model assessment of insulin resistance, interleukin 6, and high-sensitivity C-reactive protein was determined. Results: We found a direct correlation between the abnormal adipokine profile and the cardiometabolic risk indicators mentioned above, except for the low-grade inflammatory markers. In the regression model derived from our data, the leptin-to-adiponectin ratio was best correlated with the unfavorable plasma lipid profile, as estimated by the atherogenic index of plasma (r=0.097, confidence interval=0.015-0.180, p=0.021). A significantly higher leptin-to-adiponectin ratio was found in the insulin-resistant group (p=0.012) and in the highest lipid accumulation product quartile (p=0.032). Conclusion: In a non-obese young population, the high rate of leptin-adiponectin may be a good predictor of cardiovascular and metabolic risk assessment.http://balkanmedicaljournal.org/text.php?lang=en&id=2062Adipokinescardiovascular diseaseinsulin resistancenon-obeseyoung adult |
| spellingShingle | Marina Ruxandra Otelea Adrian Streinu-Cercel Cristian Băicus Maria Nitescu The Adipokine Profile and the Cardiometabolic Risk in Non-Obese Young Adults Balkan Medical Journal Adipokines cardiovascular disease insulin resistance non-obese young adult |
| title | The Adipokine Profile and the Cardiometabolic Risk in Non-Obese Young Adults |
| title_full | The Adipokine Profile and the Cardiometabolic Risk in Non-Obese Young Adults |
| title_fullStr | The Adipokine Profile and the Cardiometabolic Risk in Non-Obese Young Adults |
| title_full_unstemmed | The Adipokine Profile and the Cardiometabolic Risk in Non-Obese Young Adults |
| title_short | The Adipokine Profile and the Cardiometabolic Risk in Non-Obese Young Adults |
| title_sort | adipokine profile and the cardiometabolic risk in non obese young adults |
| topic | Adipokines cardiovascular disease insulin resistance non-obese young adult |
| url | http://balkanmedicaljournal.org/text.php?lang=en&id=2062 |
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