Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease
Alzheimer's disease (AD) is a chronic progressive neurodegenerative disorder associated with dementia and cognitive impairment most common in elderly population. Various pathophysiological mechanisms have been proposed by numerous researcher, although, exact mechanism is not yet elucidated. Sev...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.00548/full |
| _version_ | 1818134507934449664 |
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| author | Bushra Shal Wei Ding Hussain Ali Yeong S. Kim Salman Khan |
| author_facet | Bushra Shal Wei Ding Hussain Ali Yeong S. Kim Salman Khan |
| author_sort | Bushra Shal |
| collection | DOAJ |
| description | Alzheimer's disease (AD) is a chronic progressive neurodegenerative disorder associated with dementia and cognitive impairment most common in elderly population. Various pathophysiological mechanisms have been proposed by numerous researcher, although, exact mechanism is not yet elucidated. Several studies have been indicated that neuroinflammation associated with deposition of amyloid- beta (Aβ) in brain is a major hallmark toward the pathology of neurodegenerative diseases. So, there is a need to unravel the link of inflammatory process in neurodegeneration. Increased microglial activation, expression of cytokines, reactive oxygen species (ROS), and nuclear factor kappa B (NF-κB) participate in inflammatory process of AD. This review mainly concentrates on involvement of neuroinflammation and the molecular mechanisms adapted by various natural compounds, phytochemicals and herbal formulations in various signaling pathways involved in neuroprotection. Currently, pharmacologically active natural products, having anti-neuroinflammatory potential are being focused which makes them potential candidate to cure AD. A number of preclinical and clinical trials have been done on nutritional and botanical agents. Analysis of anti-inflammatory and neuroprotective phytochemicals such as terpenoids, phenolic derivatives, alkaloids, glycosides, and steroidal saponins displays therapeutic potential toward amelioration and prevention of devastating neurodegeneration observed in AD. |
| first_indexed | 2024-12-11T09:09:43Z |
| format | Article |
| id | doaj.art-033ff8fb845e43f0a95128e8a5bca8c1 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-11T09:09:43Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-033ff8fb845e43f0a95128e8a5bca8c12022-12-22T01:13:31ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-05-01910.3389/fphar.2018.00548370273Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's DiseaseBushra Shal0Wei Ding1Hussain Ali2Yeong S. Kim3Salman Khan4Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, PakistanDepartment of Neurosurgery, Rizhao Hospital of Traditional Chinese Medicine, Rizhao, ChinaDepartment of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, PakistanCollege of Pharmacy, Seoul National University, Seoul, South KoreaDepartment of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, PakistanAlzheimer's disease (AD) is a chronic progressive neurodegenerative disorder associated with dementia and cognitive impairment most common in elderly population. Various pathophysiological mechanisms have been proposed by numerous researcher, although, exact mechanism is not yet elucidated. Several studies have been indicated that neuroinflammation associated with deposition of amyloid- beta (Aβ) in brain is a major hallmark toward the pathology of neurodegenerative diseases. So, there is a need to unravel the link of inflammatory process in neurodegeneration. Increased microglial activation, expression of cytokines, reactive oxygen species (ROS), and nuclear factor kappa B (NF-κB) participate in inflammatory process of AD. This review mainly concentrates on involvement of neuroinflammation and the molecular mechanisms adapted by various natural compounds, phytochemicals and herbal formulations in various signaling pathways involved in neuroprotection. Currently, pharmacologically active natural products, having anti-neuroinflammatory potential are being focused which makes them potential candidate to cure AD. A number of preclinical and clinical trials have been done on nutritional and botanical agents. Analysis of anti-inflammatory and neuroprotective phytochemicals such as terpenoids, phenolic derivatives, alkaloids, glycosides, and steroidal saponins displays therapeutic potential toward amelioration and prevention of devastating neurodegeneration observed in AD.https://www.frontiersin.org/article/10.3389/fphar.2018.00548/fullAlzheimer's diseaseneuroinflammationnatural productsherbal formulationphytochemicalsneuroprotection |
| spellingShingle | Bushra Shal Wei Ding Hussain Ali Yeong S. Kim Salman Khan Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease Frontiers in Pharmacology Alzheimer's disease neuroinflammation natural products herbal formulation phytochemicals neuroprotection |
| title | Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease |
| title_full | Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease |
| title_fullStr | Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease |
| title_full_unstemmed | Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease |
| title_short | Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease |
| title_sort | anti neuroinflammatory potential of natural products in attenuation of alzheimer s disease |
| topic | Alzheimer's disease neuroinflammation natural products herbal formulation phytochemicals neuroprotection |
| url | https://www.frontiersin.org/article/10.3389/fphar.2018.00548/full |
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