Post-covid Multisystem Inflammatory Syndrome in children (Mis-C) with rare gastrointestinal ramifications: Case reports from a Tertiary Care Hospital in Eastern India
Children with prior coronavirus disease 2019 (COVID-19) infection display an increased systemic inflammation causing multiorgan dysfunctions in the cardiovascular, respiratory, central nervous system, and gastrointestinal (GI) systems, known as MIS-C, that is, multisystem inflammatory syndrome in ch...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
| Subjects: | |
| Online Access: | http://www.mjdrdypv.org/article.asp?issn=2589-8302;year=2022;volume=15;issue=8;spage=348;epage=352;aulast=Sahu |
| _version_ | 1811296054936600576 |
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| author | Sanjay Kumar Sahu Soumya Ranjan Mohapatra Sushant Kumar Das Ravi Kumar Nirmal Kumar Mohakud |
| author_facet | Sanjay Kumar Sahu Soumya Ranjan Mohapatra Sushant Kumar Das Ravi Kumar Nirmal Kumar Mohakud |
| author_sort | Sanjay Kumar Sahu |
| collection | DOAJ |
| description | Children with prior coronavirus disease 2019 (COVID-19) infection display an increased systemic inflammation causing multiorgan dysfunctions in the cardiovascular, respiratory, central nervous system, and gastrointestinal (GI) systems, known as MIS-C, that is, multisystem inflammatory syndrome in children. Most of the MIS-C cases have GI manifestations like pain abdomen, loose motion, vomiting or nausea, elevated liver enzymes, ileus, and bleeding. Angiotensin-converting enzyme 2 (ACE2) receptors in the terminal ileum and colon are responsible for the majority of ACE2-induced damage to these tissues. In the pandemic's second wave, a significant number of MIS-C patients with predominantly GI symptoms (around 80%) were reported. Although different molecular inflammatory mechanisms are involved, there is a significant overlap of the children's GI symptoms with those of MIS-C and other conditions of the abdomen caused by infection or inflammation, thus resulting in a diagnostic dilemma. Here, we report two cases of MIS-C with acute appendicular perforation and ileal perforation needing both medical management and surgical intervention. |
| first_indexed | 2024-04-13T05:42:43Z |
| format | Article |
| id | doaj.art-03409815c75344c4b9fad5f3b5556548 |
| institution | Directory Open Access Journal |
| issn | 2589-8302 2589-8310 |
| language | English |
| last_indexed | 2024-04-13T05:42:43Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
| spelling | doaj.art-03409815c75344c4b9fad5f3b55565482022-12-22T03:00:02ZengWolters Kluwer Medknow PublicationsMedical Journal of Dr. D.Y. Patil Vidyapeeth2589-83022589-83102022-01-0115834835210.4103/mjdrdypu.mjdrdypu_320_22Post-covid Multisystem Inflammatory Syndrome in children (Mis-C) with rare gastrointestinal ramifications: Case reports from a Tertiary Care Hospital in Eastern IndiaSanjay Kumar SahuSoumya Ranjan MohapatraSushant Kumar DasRavi KumarNirmal Kumar MohakudChildren with prior coronavirus disease 2019 (COVID-19) infection display an increased systemic inflammation causing multiorgan dysfunctions in the cardiovascular, respiratory, central nervous system, and gastrointestinal (GI) systems, known as MIS-C, that is, multisystem inflammatory syndrome in children. Most of the MIS-C cases have GI manifestations like pain abdomen, loose motion, vomiting or nausea, elevated liver enzymes, ileus, and bleeding. Angiotensin-converting enzyme 2 (ACE2) receptors in the terminal ileum and colon are responsible for the majority of ACE2-induced damage to these tissues. In the pandemic's second wave, a significant number of MIS-C patients with predominantly GI symptoms (around 80%) were reported. Although different molecular inflammatory mechanisms are involved, there is a significant overlap of the children's GI symptoms with those of MIS-C and other conditions of the abdomen caused by infection or inflammation, thus resulting in a diagnostic dilemma. Here, we report two cases of MIS-C with acute appendicular perforation and ileal perforation needing both medical management and surgical intervention.http://www.mjdrdypv.org/article.asp?issn=2589-8302;year=2022;volume=15;issue=8;spage=348;epage=352;aulast=Sahuappendicular perforationchildcovid-19gastrointestinal symptomsileal perforationmis-c |
| spellingShingle | Sanjay Kumar Sahu Soumya Ranjan Mohapatra Sushant Kumar Das Ravi Kumar Nirmal Kumar Mohakud Post-covid Multisystem Inflammatory Syndrome in children (Mis-C) with rare gastrointestinal ramifications: Case reports from a Tertiary Care Hospital in Eastern India Medical Journal of Dr. D.Y. Patil Vidyapeeth appendicular perforation child covid-19 gastrointestinal symptoms ileal perforation mis-c |
| title | Post-covid Multisystem Inflammatory Syndrome in children (Mis-C) with rare gastrointestinal ramifications: Case reports from a Tertiary Care Hospital in Eastern India |
| title_full | Post-covid Multisystem Inflammatory Syndrome in children (Mis-C) with rare gastrointestinal ramifications: Case reports from a Tertiary Care Hospital in Eastern India |
| title_fullStr | Post-covid Multisystem Inflammatory Syndrome in children (Mis-C) with rare gastrointestinal ramifications: Case reports from a Tertiary Care Hospital in Eastern India |
| title_full_unstemmed | Post-covid Multisystem Inflammatory Syndrome in children (Mis-C) with rare gastrointestinal ramifications: Case reports from a Tertiary Care Hospital in Eastern India |
| title_short | Post-covid Multisystem Inflammatory Syndrome in children (Mis-C) with rare gastrointestinal ramifications: Case reports from a Tertiary Care Hospital in Eastern India |
| title_sort | post covid multisystem inflammatory syndrome in children mis c with rare gastrointestinal ramifications case reports from a tertiary care hospital in eastern india |
| topic | appendicular perforation child covid-19 gastrointestinal symptoms ileal perforation mis-c |
| url | http://www.mjdrdypv.org/article.asp?issn=2589-8302;year=2022;volume=15;issue=8;spage=348;epage=352;aulast=Sahu |
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