Association of Hashimoto’s thyroiditis and anti-thyroid antibodies with oral lichen planus: A cross-sectional study
Hashimoto’s thyroiditis (HT) and its autoantibodies may be associated with oral lichen planus (OLP). In this cross-sectional study, we aimed to assess the relationship among HT, auto-anti-thyroid antibodies, and OLP in a Chinese population of 247 patients with oral lichen planus. Clinical manifestat...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.967988/full |
| _version_ | 1828151672761745408 |
|---|---|
| author | Tianyu Zhang Feifei Hou Dan Liu Hangfan Zhou Yutong Sun Xiaoting Deng Yiming Xu Yanxuan Xiao Xianwen Wang Chuanji Wu Yang Meng Peiyang Yuan Xuemei Qiu Lu Ye Yuye Liang Wei Wei Lu Jiang |
| author_facet | Tianyu Zhang Feifei Hou Dan Liu Hangfan Zhou Yutong Sun Xiaoting Deng Yiming Xu Yanxuan Xiao Xianwen Wang Chuanji Wu Yang Meng Peiyang Yuan Xuemei Qiu Lu Ye Yuye Liang Wei Wei Lu Jiang |
| author_sort | Tianyu Zhang |
| collection | DOAJ |
| description | Hashimoto’s thyroiditis (HT) and its autoantibodies may be associated with oral lichen planus (OLP). In this cross-sectional study, we aimed to assess the relationship among HT, auto-anti-thyroid antibodies, and OLP in a Chinese population of 247 patients with oral lichen planus. Clinical manifestations of OLP were evaluated using the Thongprasom scoring system and clinical type. The diagnosis of HT was based on thyroid function, anti-thyroid peroxidase antibody (anti-TPOAb) and anti-thyroglobulin antibody (anti-TgAb) detection, and ultrasonography. The prevalence of HT in all patients with OLP was 39.68% (98/247); the prevalence in females with OLP was 46.24% (86/186), which was higher than that in males with OLP 19.67% (12/61) (P < 0.01). The titers of the two HT autoantibodies in females with OLP were higher than those in males (P < 0.01). The clinical manifestations of OLP, regardless of being evaluated using the Thongprasom system or clinical type, were not significantly associated with HT development or TPOAb (P = 0.864) or TgAb titers (P = 0.745). In this population-based southern Chinese cohort, the prevalence of HT in patients with OLP, particularly in female patients with OLP, was significantly higher than that in the general population. Female patients had higher HT autoantibody titers than male patients. However, the clinical manifestations of OLP were not significantly correlated with either HT development or auto-anti-thyroid antibody levels. The findings could help further elucidate the factors involved in the relationship between oral lichen planus and Hashimoto’s thyroiditis. |
| first_indexed | 2024-04-11T22:00:58Z |
| format | Article |
| id | doaj.art-03413cf289da4becbc12d61aa0ef0497 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T22:00:58Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-03413cf289da4becbc12d61aa0ef04972022-12-22T04:00:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.967988967988Association of Hashimoto’s thyroiditis and anti-thyroid antibodies with oral lichen planus: A cross-sectional studyTianyu Zhang0Feifei Hou1Dan Liu2Hangfan Zhou3Yutong Sun4Xiaoting Deng5Yiming Xu6Yanxuan Xiao7Xianwen Wang8Chuanji Wu9Yang Meng10Peiyang Yuan11Xuemei Qiu12Lu Ye13Yuye Liang14Wei Wei15Lu Jiang16State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaDepartment of Emergency, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaHashimoto’s thyroiditis (HT) and its autoantibodies may be associated with oral lichen planus (OLP). In this cross-sectional study, we aimed to assess the relationship among HT, auto-anti-thyroid antibodies, and OLP in a Chinese population of 247 patients with oral lichen planus. Clinical manifestations of OLP were evaluated using the Thongprasom scoring system and clinical type. The diagnosis of HT was based on thyroid function, anti-thyroid peroxidase antibody (anti-TPOAb) and anti-thyroglobulin antibody (anti-TgAb) detection, and ultrasonography. The prevalence of HT in all patients with OLP was 39.68% (98/247); the prevalence in females with OLP was 46.24% (86/186), which was higher than that in males with OLP 19.67% (12/61) (P < 0.01). The titers of the two HT autoantibodies in females with OLP were higher than those in males (P < 0.01). The clinical manifestations of OLP, regardless of being evaluated using the Thongprasom system or clinical type, were not significantly associated with HT development or TPOAb (P = 0.864) or TgAb titers (P = 0.745). In this population-based southern Chinese cohort, the prevalence of HT in patients with OLP, particularly in female patients with OLP, was significantly higher than that in the general population. Female patients had higher HT autoantibody titers than male patients. However, the clinical manifestations of OLP were not significantly correlated with either HT development or auto-anti-thyroid antibody levels. The findings could help further elucidate the factors involved in the relationship between oral lichen planus and Hashimoto’s thyroiditis.https://www.frontiersin.org/articles/10.3389/fimmu.2022.967988/fulloral lichen planusHashimoto’s thyroiditisautoantibodiesTPOAb thyroperoxidase antibodiesTgAb thyroglobulin |
| spellingShingle | Tianyu Zhang Feifei Hou Dan Liu Hangfan Zhou Yutong Sun Xiaoting Deng Yiming Xu Yanxuan Xiao Xianwen Wang Chuanji Wu Yang Meng Peiyang Yuan Xuemei Qiu Lu Ye Yuye Liang Wei Wei Lu Jiang Association of Hashimoto’s thyroiditis and anti-thyroid antibodies with oral lichen planus: A cross-sectional study Frontiers in Immunology oral lichen planus Hashimoto’s thyroiditis autoantibodies TPOAb thyroperoxidase antibodies TgAb thyroglobulin |
| title | Association of Hashimoto’s thyroiditis and anti-thyroid antibodies with oral lichen planus: A cross-sectional study |
| title_full | Association of Hashimoto’s thyroiditis and anti-thyroid antibodies with oral lichen planus: A cross-sectional study |
| title_fullStr | Association of Hashimoto’s thyroiditis and anti-thyroid antibodies with oral lichen planus: A cross-sectional study |
| title_full_unstemmed | Association of Hashimoto’s thyroiditis and anti-thyroid antibodies with oral lichen planus: A cross-sectional study |
| title_short | Association of Hashimoto’s thyroiditis and anti-thyroid antibodies with oral lichen planus: A cross-sectional study |
| title_sort | association of hashimoto s thyroiditis and anti thyroid antibodies with oral lichen planus a cross sectional study |
| topic | oral lichen planus Hashimoto’s thyroiditis autoantibodies TPOAb thyroperoxidase antibodies TgAb thyroglobulin |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.967988/full |
| work_keys_str_mv | AT tianyuzhang associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT feifeihou associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT danliu associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT hangfanzhou associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT yutongsun associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT xiaotingdeng associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT yimingxu associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT yanxuanxiao associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT xianwenwang associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT chuanjiwu associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT yangmeng associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT peiyangyuan associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT xuemeiqiu associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT luye associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT yuyeliang associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT weiwei associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy AT lujiang associationofhashimotosthyroiditisandantithyroidantibodieswithorallichenplanusacrosssectionalstudy |