Prenatal Nutritional Intervention Reduces Autistic-Like Behavior Rates Among Mthfr-Deficient Mice

Prenatal Nutritional Intervention Reduces Autistic-Like Behavior Rates Among Mthfr-Deficient Mice

The causes and contributing factors of autism spectrum disorders (ASD) are poorly understood. One gene associated with increased risk for ASD is methylenetetrahydrofolate-reductase (MTHFR), which encodes a key enzyme in one carbon (C1) metabolism. The MTHFR 677C > T polymorphism reduces the e...

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Bibliographic Details
Main Authors: Ayelet Orenbuch, Keren Fortis, Siraphat Taesuwan, Raz Yaffe, Marie A. Caudill, Hava M. Golan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Neuroscience
Subjects:
autism
one-carbon metabolism
choline
GABA
glutamate receptors
H3
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00383/full

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