Bilateral transcranial direct‐current stimulation promotes migration of subventricular zone‐derived neuroblasts toward ischemic brain
Abstract Ischemic insult stimulates proliferation of neural stem cells (NSCs) in the subventricular zone (SVZ) after stroke. However, only a fraction of NSC‐derived neuroblasts from SVZ migrate toward poststroke brain region. We have previously reported that direct‐current stimulation guides NSC mig...
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | FASEB BioAdvances |
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| Online Access: | https://doi.org/10.1096/fba.2023-00017 |
| _version_ | 1827907940024057856 |
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| author | Ruixue Lei Shu Wang Anchun Liu Jing Cheng Zhifeng Zhang Jinyang Ren Xujin Yao Xiangyi Kong Wenlong Ma Fengyuan Che Juan Chen Qi Wan |
| author_facet | Ruixue Lei Shu Wang Anchun Liu Jing Cheng Zhifeng Zhang Jinyang Ren Xujin Yao Xiangyi Kong Wenlong Ma Fengyuan Che Juan Chen Qi Wan |
| author_sort | Ruixue Lei |
| collection | DOAJ |
| description | Abstract Ischemic insult stimulates proliferation of neural stem cells (NSCs) in the subventricular zone (SVZ) after stroke. However, only a fraction of NSC‐derived neuroblasts from SVZ migrate toward poststroke brain region. We have previously reported that direct‐current stimulation guides NSC migration toward the cathode in vitro. Accordingly, we set up a new method of transcranial direct‐current stimulation (tDCS), in which the cathodal electrode is placed on the ischemic hemisphere and anodal electrode on the contralateral hemisphere of rats subjected to ischemia–reperfusion injury. We show that the application of this bilateral tDCS (BtDCS) promotes the migration of NSC‐derived neuroblasts from SVZ toward the cathode direction into poststroke striatum. Reversing the position of the electrodes blocks the effect of BtDCS on the migration of neuroblasts from SVZ. BtDCS protects against neuronal death and improves the functional recovery of stroke animals. Thus, the migration of NSC‐derived neuroblasts from SVZ toward poststroke brain region contributes to the effect of BtDCS against ischemia‐induced neuronal death, supporting a potential development of noninvasive BtDCS as an endogenous neurogenesis‐based stroke therapy. |
| first_indexed | 2024-03-13T01:15:09Z |
| format | Article |
| id | doaj.art-03456674149f44e5bdd006b81a00a14d |
| institution | Directory Open Access Journal |
| issn | 2573-9832 |
| language | English |
| last_indexed | 2024-03-13T01:15:09Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | FASEB BioAdvances |
| spelling | doaj.art-03456674149f44e5bdd006b81a00a14d2023-07-05T10:51:44ZengWileyFASEB BioAdvances2573-98322023-07-015727728610.1096/fba.2023-00017Bilateral transcranial direct‐current stimulation promotes migration of subventricular zone‐derived neuroblasts toward ischemic brainRuixue Lei0Shu Wang1Anchun Liu2Jing Cheng3Zhifeng Zhang4Jinyang Ren5Xujin Yao6Xiangyi Kong7Wenlong Ma8Fengyuan Che9Juan Chen10Qi Wan11Department of Pathology, Anyang Tumour Hospital The Affiliated Anyang Tumor Hospital of Henan University of Science and Technology Anyang Henan ChinaDepartment of Physiology, School of Medicine Wuhan University Wuhan ChinaDepartment of Physiology, School of Medicine Wuhan University Wuhan ChinaDepartment of Physiology, School of Medicine Wuhan University Wuhan ChinaDepartment of Physiology, School of Medicine Wuhan University Wuhan ChinaInstitute of Neuroregeneration & Neurorehabilitation, Department of Neurosurgery Qingdao University Qingdao ChinaInstitute of Neuroregeneration & Neurorehabilitation, Department of Neurosurgery Qingdao University Qingdao ChinaInstitute of Neuroregeneration & Neurorehabilitation, Department of Neurosurgery Qingdao University Qingdao ChinaInstitute of Neuroregeneration & Neurorehabilitation, Department of Neurosurgery Qingdao University Qingdao ChinaCentral Laboratory, Department of Neurology Linyi People's Hospital, Qingdao University Linyi Shandong ChinaDepartment of Neurology, the Central Hospital of Wuhan tongji medical collof Huazhong University of Science & Technology Wuhan ChinaDepartment of Physiology, School of Medicine Wuhan University Wuhan ChinaAbstract Ischemic insult stimulates proliferation of neural stem cells (NSCs) in the subventricular zone (SVZ) after stroke. However, only a fraction of NSC‐derived neuroblasts from SVZ migrate toward poststroke brain region. We have previously reported that direct‐current stimulation guides NSC migration toward the cathode in vitro. Accordingly, we set up a new method of transcranial direct‐current stimulation (tDCS), in which the cathodal electrode is placed on the ischemic hemisphere and anodal electrode on the contralateral hemisphere of rats subjected to ischemia–reperfusion injury. We show that the application of this bilateral tDCS (BtDCS) promotes the migration of NSC‐derived neuroblasts from SVZ toward the cathode direction into poststroke striatum. Reversing the position of the electrodes blocks the effect of BtDCS on the migration of neuroblasts from SVZ. BtDCS protects against neuronal death and improves the functional recovery of stroke animals. Thus, the migration of NSC‐derived neuroblasts from SVZ toward poststroke brain region contributes to the effect of BtDCS against ischemia‐induced neuronal death, supporting a potential development of noninvasive BtDCS as an endogenous neurogenesis‐based stroke therapy.https://doi.org/10.1096/fba.2023-00017ischemic strokeneural stem cellsstem cell migrationsubventricular zonetranscranial direct‐current stimulation |
| spellingShingle | Ruixue Lei Shu Wang Anchun Liu Jing Cheng Zhifeng Zhang Jinyang Ren Xujin Yao Xiangyi Kong Wenlong Ma Fengyuan Che Juan Chen Qi Wan Bilateral transcranial direct‐current stimulation promotes migration of subventricular zone‐derived neuroblasts toward ischemic brain FASEB BioAdvances ischemic stroke neural stem cells stem cell migration subventricular zone transcranial direct‐current stimulation |
| title | Bilateral transcranial direct‐current stimulation promotes migration of subventricular zone‐derived neuroblasts toward ischemic brain |
| title_full | Bilateral transcranial direct‐current stimulation promotes migration of subventricular zone‐derived neuroblasts toward ischemic brain |
| title_fullStr | Bilateral transcranial direct‐current stimulation promotes migration of subventricular zone‐derived neuroblasts toward ischemic brain |
| title_full_unstemmed | Bilateral transcranial direct‐current stimulation promotes migration of subventricular zone‐derived neuroblasts toward ischemic brain |
| title_short | Bilateral transcranial direct‐current stimulation promotes migration of subventricular zone‐derived neuroblasts toward ischemic brain |
| title_sort | bilateral transcranial direct current stimulation promotes migration of subventricular zone derived neuroblasts toward ischemic brain |
| topic | ischemic stroke neural stem cells stem cell migration subventricular zone transcranial direct‐current stimulation |
| url | https://doi.org/10.1096/fba.2023-00017 |
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