Assessing the contribution of mild high-altitude exposure to obstructive sleep apnea-hypopnea syndrome comorbidities
BackgroundObstructive sleep apnea-hypopnea syndrome (OSAHS) is a common sleep disorder. The lower atmospheric pressure and decreased oxygen levels of high-altitude areas can exacerbate the severity of OSAHS, but research into OSAHS in high-altitude areas remains limited. This study, from June 2015 t...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1191233/full |
| _version_ | 1797362515088244736 |
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| author | Lijuan Hao Kangkang Peng Qi Bian Suting Guo Chengmin Duan Lei Feng Zhenguo Chen Caiang Renzeng Huaixia Pang Zhen Ma |
| author_facet | Lijuan Hao Kangkang Peng Qi Bian Suting Guo Chengmin Duan Lei Feng Zhenguo Chen Caiang Renzeng Huaixia Pang Zhen Ma |
| author_sort | Lijuan Hao |
| collection | DOAJ |
| description | BackgroundObstructive sleep apnea-hypopnea syndrome (OSAHS) is a common sleep disorder. The lower atmospheric pressure and decreased oxygen levels of high-altitude areas can exacerbate the severity of OSAHS, but research into OSAHS in high-altitude areas remains limited. This study, from June 2015 to January 2020, involved 4,667 patients with suspected OSAHS and 38 healthy volunteers. The non-OSAHS group (AHI <5/h) had 395 patients, while the larger OSAHS group (AHI ≥5/h) comprised 4,272 patients. The significant size difference between the groups emphasized the study’s focus on OSAHS, using the non-OSAHS mainly for comparison.MethodsSleep technicians monitored the OSAHS patient group overnight by polysomnography (PSG), the apnea-hypopnea index (AHI), the mean oxygen saturation (MSpO2), lowest oxygen saturation (LSpO2), the oxygen desaturation index (ODI) and the total sleep time with oxygen saturation less than 90% (TST-SpO2 <90%). Healthy volunteers self-monitored sleep patterns at home, using the CONTEC RS01 respiration sleep monitor with a wristwatch sleep apnea screen meter. The RSO1 wristwatch-style device has already been studied for consistency and sensitivity with the Alice-6 standard multi-lead sleep monitor and can be used for OSAHS screening in this region.ResultsLSpO2 recordings from healthy volunteers (86.36 ± 3.57%) and non-OSAHS (AHI <5/h) cohort (78.59 ± 11.99%) were much lower than previously reported normal values. Regression analysis identified no correlations between AHI levels and MSpO2 or TST-SpO2 <90%, weak correlations between AHI levels and LSpO2 or MSpO2, and a strongly significant correlation between AHI levels and the ODI (r = 0.76, p < 0.05). The data also indicated that the appropriate clinical thresholds for OSAHS patients living at mild high altitude are classified as mild, moderate, or severe based on LSpO2 saturation criteria of 0.85–0.90, 0.65–0.84, or <0.65, respectively.ConclusionThe study findings suggest that individuals with an AHI score below 5 in OSAHS, who reside in high-altitude areas, also require closer monitoring due to the elevated risk of nocturnal hypoxia. Furthermore, the significant correlation between ODI values and the severity of OSAHS emphasizes the importance of considering treatment options. Additionally, the assessment of hypoxemia severity thresholds in OSAHS patients living in high-altitude regions provides valuable insights for refining diagnostic guidelines. |
| first_indexed | 2024-03-08T16:07:59Z |
| format | Article |
| id | doaj.art-03457910a0bc460c8d47a852ff70fb9f |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-08T16:07:59Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-03457910a0bc460c8d47a852ff70fb9f2024-01-08T04:28:27ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-01-011410.3389/fneur.2023.11912331191233Assessing the contribution of mild high-altitude exposure to obstructive sleep apnea-hypopnea syndrome comorbiditiesLijuan Hao0Kangkang Peng1Qi Bian2Suting Guo3Chengmin Duan4Lei Feng5Zhenguo Chen6Caiang Renzeng7Huaixia Pang8Zhen Ma9Department of Sleep Medicine, Qinghai Red Cross Hospital, Xining, ChinaDepartment of Sleep Medicine, Qinghai Red Cross Hospital, Xining, ChinaDepartment of Otolaryngology, Graduate School of Qinghai University, Xining, ChinaDepartment of Otolaryngology, Graduate School of Qinghai University, Xining, ChinaDepartment of Sleep Medicine, Qinghai Red Cross Hospital, Xining, ChinaDepartment of Sleep Medicine, Qinghai Red Cross Hospital, Xining, ChinaDepartment of Sleep Medicine, Qinghai Red Cross Hospital, Xining, ChinaDepartment of Sleep Medicine, Qinghai Red Cross Hospital, Xining, ChinaDepartment of Sleep Medicine, Qinghai Red Cross Hospital, Xining, ChinaDepartment of Sleep Medicine, Qinghai Red Cross Hospital, Xining, ChinaBackgroundObstructive sleep apnea-hypopnea syndrome (OSAHS) is a common sleep disorder. The lower atmospheric pressure and decreased oxygen levels of high-altitude areas can exacerbate the severity of OSAHS, but research into OSAHS in high-altitude areas remains limited. This study, from June 2015 to January 2020, involved 4,667 patients with suspected OSAHS and 38 healthy volunteers. The non-OSAHS group (AHI <5/h) had 395 patients, while the larger OSAHS group (AHI ≥5/h) comprised 4,272 patients. The significant size difference between the groups emphasized the study’s focus on OSAHS, using the non-OSAHS mainly for comparison.MethodsSleep technicians monitored the OSAHS patient group overnight by polysomnography (PSG), the apnea-hypopnea index (AHI), the mean oxygen saturation (MSpO2), lowest oxygen saturation (LSpO2), the oxygen desaturation index (ODI) and the total sleep time with oxygen saturation less than 90% (TST-SpO2 <90%). Healthy volunteers self-monitored sleep patterns at home, using the CONTEC RS01 respiration sleep monitor with a wristwatch sleep apnea screen meter. The RSO1 wristwatch-style device has already been studied for consistency and sensitivity with the Alice-6 standard multi-lead sleep monitor and can be used for OSAHS screening in this region.ResultsLSpO2 recordings from healthy volunteers (86.36 ± 3.57%) and non-OSAHS (AHI <5/h) cohort (78.59 ± 11.99%) were much lower than previously reported normal values. Regression analysis identified no correlations between AHI levels and MSpO2 or TST-SpO2 <90%, weak correlations between AHI levels and LSpO2 or MSpO2, and a strongly significant correlation between AHI levels and the ODI (r = 0.76, p < 0.05). The data also indicated that the appropriate clinical thresholds for OSAHS patients living at mild high altitude are classified as mild, moderate, or severe based on LSpO2 saturation criteria of 0.85–0.90, 0.65–0.84, or <0.65, respectively.ConclusionThe study findings suggest that individuals with an AHI score below 5 in OSAHS, who reside in high-altitude areas, also require closer monitoring due to the elevated risk of nocturnal hypoxia. Furthermore, the significant correlation between ODI values and the severity of OSAHS emphasizes the importance of considering treatment options. Additionally, the assessment of hypoxemia severity thresholds in OSAHS patients living in high-altitude regions provides valuable insights for refining diagnostic guidelines.https://www.frontiersin.org/articles/10.3389/fneur.2023.1191233/fullobstructive sleep apnea-hypopnea syndromeapneaoxygen desaturation indexhyponea treatmentmild high altitude |
| spellingShingle | Lijuan Hao Kangkang Peng Qi Bian Suting Guo Chengmin Duan Lei Feng Zhenguo Chen Caiang Renzeng Huaixia Pang Zhen Ma Assessing the contribution of mild high-altitude exposure to obstructive sleep apnea-hypopnea syndrome comorbidities Frontiers in Neurology obstructive sleep apnea-hypopnea syndrome apnea oxygen desaturation index hyponea treatment mild high altitude |
| title | Assessing the contribution of mild high-altitude exposure to obstructive sleep apnea-hypopnea syndrome comorbidities |
| title_full | Assessing the contribution of mild high-altitude exposure to obstructive sleep apnea-hypopnea syndrome comorbidities |
| title_fullStr | Assessing the contribution of mild high-altitude exposure to obstructive sleep apnea-hypopnea syndrome comorbidities |
| title_full_unstemmed | Assessing the contribution of mild high-altitude exposure to obstructive sleep apnea-hypopnea syndrome comorbidities |
| title_short | Assessing the contribution of mild high-altitude exposure to obstructive sleep apnea-hypopnea syndrome comorbidities |
| title_sort | assessing the contribution of mild high altitude exposure to obstructive sleep apnea hypopnea syndrome comorbidities |
| topic | obstructive sleep apnea-hypopnea syndrome apnea oxygen desaturation index hyponea treatment mild high altitude |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1191233/full |
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