Limited Impact of Delta Variant’s Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population
The SARS-CoV-2 pandemic has impacted public health systems all over the world. The Delta variant seems to possess enhanced transmissibility, but no clear evidence suggests it has increased virulence. Our data show that pre-exposed individuals had similar neutralizing activity against the authentic C...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/12/2405 |
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| author | Carlos A. Sariol Crisanta Serrano-Collazo Edwin J. Ortiz Petraleigh Pantoja Lorna Cruz Teresa Arana Dianne Atehortua Christina Pabon-Carrero Ana M. Espino |
| author_facet | Carlos A. Sariol Crisanta Serrano-Collazo Edwin J. Ortiz Petraleigh Pantoja Lorna Cruz Teresa Arana Dianne Atehortua Christina Pabon-Carrero Ana M. Espino |
| author_sort | Carlos A. Sariol |
| collection | DOAJ |
| description | The SARS-CoV-2 pandemic has impacted public health systems all over the world. The Delta variant seems to possess enhanced transmissibility, but no clear evidence suggests it has increased virulence. Our data show that pre-exposed individuals had similar neutralizing activity against the authentic COVID-19 strain and the Delta and Epsilon variants. After only one vaccine dose, the neutralization capacity expanded to all tested variants in pre-exposed individuals. Healthy vaccinated individuals showed a limited breadth of neutralization. One vaccine dose did induce similar neutralizing antibodies against the Delta as against the authentic strain. However, even after two doses, this capacity only expanded to the Epsilon variant. |
| first_indexed | 2024-03-10T03:54:44Z |
| format | Article |
| id | doaj.art-03468c76190f4aa2890f73a70edf1938 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T03:54:44Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-03468c76190f4aa2890f73a70edf19382023-11-23T10:57:28ZengMDPI AGViruses1999-49152021-11-011312240510.3390/v13122405Limited Impact of Delta Variant’s Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino PopulationCarlos A. Sariol0Crisanta Serrano-Collazo1Edwin J. Ortiz2Petraleigh Pantoja3Lorna Cruz4Teresa Arana5Dianne Atehortua6Christina Pabon-Carrero7Ana M. Espino8Department of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USAUnit of Comparative Medicine, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USAUnit of Comparative Medicine, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USAUnit of Comparative Medicine, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USADepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USADepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USAPuerto Rico Science, Technology and Research Trust, San Juan, PR 00927, USAPuerto Rico Science, Technology and Research Trust, San Juan, PR 00927, USADepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USAThe SARS-CoV-2 pandemic has impacted public health systems all over the world. The Delta variant seems to possess enhanced transmissibility, but no clear evidence suggests it has increased virulence. Our data show that pre-exposed individuals had similar neutralizing activity against the authentic COVID-19 strain and the Delta and Epsilon variants. After only one vaccine dose, the neutralization capacity expanded to all tested variants in pre-exposed individuals. Healthy vaccinated individuals showed a limited breadth of neutralization. One vaccine dose did induce similar neutralizing antibodies against the Delta as against the authentic strain. However, even after two doses, this capacity only expanded to the Epsilon variant.https://www.mdpi.com/1999-4915/13/12/2405SARS-CoV-2COVID-19 vaccineneutralizationserologyprotection |
| spellingShingle | Carlos A. Sariol Crisanta Serrano-Collazo Edwin J. Ortiz Petraleigh Pantoja Lorna Cruz Teresa Arana Dianne Atehortua Christina Pabon-Carrero Ana M. Espino Limited Impact of Delta Variant’s Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population Viruses SARS-CoV-2 COVID-19 vaccine neutralization serology protection |
| title | Limited Impact of Delta Variant’s Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population |
| title_full | Limited Impact of Delta Variant’s Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population |
| title_fullStr | Limited Impact of Delta Variant’s Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population |
| title_full_unstemmed | Limited Impact of Delta Variant’s Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population |
| title_short | Limited Impact of Delta Variant’s Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population |
| title_sort | limited impact of delta variant s mutations on the effectiveness of neutralization conferred by natural infection or covid 19 vaccines in a latino population |
| topic | SARS-CoV-2 COVID-19 vaccine neutralization serology protection |
| url | https://www.mdpi.com/1999-4915/13/12/2405 |
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