| Summary: | Introduction: Current study was carried out as per the government of India and Himachal Pradesh guidelines to carry out a serosurvey to assess the extent of COVID-19 infection among health care professionals (HCPs) after 6 months of managing COVID-19 cases. Methods: A hospital-based survey was carried out among 1279 conveniently selected HCPs from September 2020 to January 2021. Results: The participants had a mean age of 38.3 (±10.4) years, and almost half (47.4%) were ≤35 years of age. A total of 29 (2.3%) were already tested positive for COVID-19 (RT-PCR: 22; Rapid Antigen Test: 7) before the survey, and the overall prevalence of IgG antibody was 12.7% among the participants (Male: 12.8%; Females: 12.5%). The odds were observed significantly high among administrative staff (aOR: 5.09; 95%CI: 1.27–20.33) and participants tested positive of COVID-19 previously (aOR: 28.41; 95%CI: 11.71–69.00). Conclusion: HCPs were tested about 6 months after the initiation of the COVID-19 pandemic in the state and demonstrated a high and expected level of seroprevalence.
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