DDGun: an untrained method for the prediction of protein stability changes upon single and multiple point variations

DDGun: an untrained method for the prediction of protein stability changes upon single and multiple point variations

Abstract Background Predicting the effect of single point variations on protein stability constitutes a crucial step toward understanding the relationship between protein structure and function. To this end, several methods have been developed to predict changes in the Gibbs free energy of unfolding...

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Bibliographic Details
Main Authors: Ludovica Montanucci, Emidio Capriotti, Yotam Frank, Nir Ben-Tal, Piero Fariselli
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Bioinformatics
Subjects:
Unfolding free energy change
Multiple site variation
Protein stability
Protein variant
Online Access:http://link.springer.com/article/10.1186/s12859-019-2923-1

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