A study of Vitamin D and parathyroid hormone levels in patients with prostatic cancer
Background: Vitamin D, a key nutrient in the body, has been linked to a decrease in prostate cancer (PCa) morbidity and mortality rates. The study concluded that any compensation mechanism may no longer be adequate for patients with PCa, and further research is needed to understand the mechanisms un...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2024-03-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/60561 |
| _version_ | 1797285505840185344 |
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| author | Md. Nasim Akhtar Kayyum Khan Shahnawaz Alam Mohit Mishra Sachin Rathod Waqas Alauddin |
| author_facet | Md. Nasim Akhtar Kayyum Khan Shahnawaz Alam Mohit Mishra Sachin Rathod Waqas Alauddin |
| author_sort | Md. Nasim Akhtar |
| collection | DOAJ |
| description | Background: Vitamin D, a key nutrient in the body, has been linked to a decrease in prostate cancer (PCa) morbidity and mortality rates. The study concluded that any compensation mechanism may no longer be adequate for patients with PCa, and further research is needed to understand the mechanisms underlying the relationship between serum Vitamin D and parathyroid hormone (PTH) homeostasis. The findings will help determine cancer prevalence and trends in India and support public health initiatives to control cancer.
Aims and Objectives: The aim is to assess the mean values of Vitamin D and PTH in patients with PCa and also to compare these levels with that of healthy controls (non-PCa).
Materials and Methods: One hundred participants in the outpatient department of the Department of Biochemistry were assigned as control subjects, and another 100 participants were participants with PCa. 5 mL of fasting venous blood were drawn into red top vials using a disposable syringe and needle in an aseptic manner. PTH and serum Vitamin D were estimated.
Results: When comparing PCa patients to healthy controls, the observed Vitamin D level was significantly lower in the former group. Furthermore, a notable distinction in Vitamin D levels was noted between the two groups. Furthermore, we found that PCa patients had higher PTH values than healthy controls. When we compared the PTH values of the two groups, we found a substantial difference.
Conclusion: The authors conclude from the study that with alterations in the study parameters in patients with PCa, any compensation mechanism may become insufficient. |
| first_indexed | 2024-03-07T18:03:12Z |
| format | Article |
| id | doaj.art-034a00bf86424a86af1c0240ab482425 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-07T18:03:12Z |
| publishDate | 2024-03-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-034a00bf86424a86af1c0240ab4824252024-03-02T09:54:11ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762024-03-01153122126https://doi.org/10.3126/ajms.v15i3.60561A study of Vitamin D and parathyroid hormone levels in patients with prostatic cancerMd. Nasim Akhtar 0https://orcid.org/0000-0002-5144-5486Kayyum Khan 1https://orcid.org/0009-0009-8107-0978Shahnawaz Alam 2https://orcid.org/0000-0001-7292-1907Mohit Mishra 3https://orcid.org/0009-0003-8719-7618Sachin Rathod 4https://orcid.org/0009-0007-9645-3192Waqas Alauddin 5https://orcid.org/0000-0001-5270-8164Assistant Professor, Department of Biochemistry, Naraina Medical College and Research Centre, Kanpur, Uttar Pradesh, India Tutor, Department of Microbiology, Naraina Medical College and Research Centre, Kanpur, Uttar Pradesh, India Associate Professor, Department of Physiology, Naraina Medical College and Research Centre, Kanpur, Uttar Pradesh, India Assistant Professor, Department of Physiology, Naraina Medical College and Research Centre, Kanpur, Uttar Pradesh, India Professor and Head, Department of Physiology, Naraina Medical College and Research Centre, Kanpur, Uttar Pradesh, India Assistant Professor, Department of Physiology, Naraina Medical College and Research Centre, Kanpur, Uttar Pradesh, India Background: Vitamin D, a key nutrient in the body, has been linked to a decrease in prostate cancer (PCa) morbidity and mortality rates. The study concluded that any compensation mechanism may no longer be adequate for patients with PCa, and further research is needed to understand the mechanisms underlying the relationship between serum Vitamin D and parathyroid hormone (PTH) homeostasis. The findings will help determine cancer prevalence and trends in India and support public health initiatives to control cancer. Aims and Objectives: The aim is to assess the mean values of Vitamin D and PTH in patients with PCa and also to compare these levels with that of healthy controls (non-PCa). Materials and Methods: One hundred participants in the outpatient department of the Department of Biochemistry were assigned as control subjects, and another 100 participants were participants with PCa. 5 mL of fasting venous blood were drawn into red top vials using a disposable syringe and needle in an aseptic manner. PTH and serum Vitamin D were estimated. Results: When comparing PCa patients to healthy controls, the observed Vitamin D level was significantly lower in the former group. Furthermore, a notable distinction in Vitamin D levels was noted between the two groups. Furthermore, we found that PCa patients had higher PTH values than healthy controls. When we compared the PTH values of the two groups, we found a substantial difference. Conclusion: The authors conclude from the study that with alterations in the study parameters in patients with PCa, any compensation mechanism may become insufficient.https://www.nepjol.info/index.php/AJMS/article/view/60561prostate cancer; vitamin d; parathyroid hormone; immunomodulation; prostate-specific antigen |
| spellingShingle | Md. Nasim Akhtar Kayyum Khan Shahnawaz Alam Mohit Mishra Sachin Rathod Waqas Alauddin A study of Vitamin D and parathyroid hormone levels in patients with prostatic cancer Asian Journal of Medical Sciences prostate cancer; vitamin d; parathyroid hormone; immunomodulation; prostate-specific antigen |
| title | A study of Vitamin D and parathyroid hormone levels in patients with prostatic cancer |
| title_full | A study of Vitamin D and parathyroid hormone levels in patients with prostatic cancer |
| title_fullStr | A study of Vitamin D and parathyroid hormone levels in patients with prostatic cancer |
| title_full_unstemmed | A study of Vitamin D and parathyroid hormone levels in patients with prostatic cancer |
| title_short | A study of Vitamin D and parathyroid hormone levels in patients with prostatic cancer |
| title_sort | study of vitamin d and parathyroid hormone levels in patients with prostatic cancer |
| topic | prostate cancer; vitamin d; parathyroid hormone; immunomodulation; prostate-specific antigen |
| url | https://www.nepjol.info/index.php/AJMS/article/view/60561 |
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