The Hydrolysis of Phosphinates and Phosphonates: A Review
Phosphinic and phosphonic acids are useful intermediates and biologically active compounds which may be prepared from their esters, phosphinates and phosphonates, respectively, by hydrolysis or dealkylation. The hydrolysis may take place both under acidic and basic conditions, but the C-O bond may a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/10/2840 |
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| author | Nikoletta Harsági György Keglevich |
| author_facet | Nikoletta Harsági György Keglevich |
| author_sort | Nikoletta Harsági |
| collection | DOAJ |
| description | Phosphinic and phosphonic acids are useful intermediates and biologically active compounds which may be prepared from their esters, phosphinates and phosphonates, respectively, by hydrolysis or dealkylation. The hydrolysis may take place both under acidic and basic conditions, but the C-O bond may also be cleaved by trimethylsilyl halides. The hydrolysis of <i>P</i>-esters is a challenging task because, in most cases, the optimized reaction conditions have not yet been explored. Despite the importance of the hydrolysis of <i>P</i>-esters, this field has not yet been fully surveyed. In order to fill this gap, examples of acidic and alkaline hydrolysis, as well as the dealkylation of phosphinates and phosphonates, are summarized in this review. |
| first_indexed | 2024-03-10T11:32:18Z |
| format | Article |
| id | doaj.art-034abdba6e044b8e85066f58f93bf47e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T11:32:18Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-034abdba6e044b8e85066f58f93bf47e2023-11-21T19:09:10ZengMDPI AGMolecules1420-30492021-05-012610284010.3390/molecules26102840The Hydrolysis of Phosphinates and Phosphonates: A ReviewNikoletta Harsági0György Keglevich1Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, HungaryDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, HungaryPhosphinic and phosphonic acids are useful intermediates and biologically active compounds which may be prepared from their esters, phosphinates and phosphonates, respectively, by hydrolysis or dealkylation. The hydrolysis may take place both under acidic and basic conditions, but the C-O bond may also be cleaved by trimethylsilyl halides. The hydrolysis of <i>P</i>-esters is a challenging task because, in most cases, the optimized reaction conditions have not yet been explored. Despite the importance of the hydrolysis of <i>P</i>-esters, this field has not yet been fully surveyed. In order to fill this gap, examples of acidic and alkaline hydrolysis, as well as the dealkylation of phosphinates and phosphonates, are summarized in this review.https://www.mdpi.com/1420-3049/26/10/2840hydrolysisdealkylationphosphinatesphosphonates<i>P</i>-acids |
| spellingShingle | Nikoletta Harsági György Keglevich The Hydrolysis of Phosphinates and Phosphonates: A Review Molecules hydrolysis dealkylation phosphinates phosphonates <i>P</i>-acids |
| title | The Hydrolysis of Phosphinates and Phosphonates: A Review |
| title_full | The Hydrolysis of Phosphinates and Phosphonates: A Review |
| title_fullStr | The Hydrolysis of Phosphinates and Phosphonates: A Review |
| title_full_unstemmed | The Hydrolysis of Phosphinates and Phosphonates: A Review |
| title_short | The Hydrolysis of Phosphinates and Phosphonates: A Review |
| title_sort | hydrolysis of phosphinates and phosphonates a review |
| topic | hydrolysis dealkylation phosphinates phosphonates <i>P</i>-acids |
| url | https://www.mdpi.com/1420-3049/26/10/2840 |
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