Protective Effects of High-Density Lipoprotein on Cancer Risk: Focus on Multiple Myeloma
Lipid metabolism is intrinsically linked to tumorigenesis. And one of the most important characteristics of cancer is the modification of lipid metabolism and its correlation with oncogenic signaling pathways within the tumors. Because lipids function as signaling molecules, membrane structures, and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/3/514 |
| _version_ | 1797241975673454592 |
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| author | Alessandro Allegra Giuseppe Murdaca Giuseppe Mirabile Sebastiano Gangemi |
| author_facet | Alessandro Allegra Giuseppe Murdaca Giuseppe Mirabile Sebastiano Gangemi |
| author_sort | Alessandro Allegra |
| collection | DOAJ |
| description | Lipid metabolism is intrinsically linked to tumorigenesis. And one of the most important characteristics of cancer is the modification of lipid metabolism and its correlation with oncogenic signaling pathways within the tumors. Because lipids function as signaling molecules, membrane structures, and energy sources, lipids are essential to the development of cancer. Above all, the proper immune response of tumor cells depends on the control of lipid metabolism. Changes in metabolism can modify systems that regulate carcinogenesis, such as inflammation, oxidative stress, and angiogenesis. The dependence of various malignancies on lipid metabolism varies. This review delves into the modifications to lipid metabolism that take place in cancer, specifically focusing on multiple myeloma. The review illustrates how changes in different lipid pathways impact the growth, survival, and drug-responsiveness of multiple myeloma cells, in addition to their interactions with other cells within the tumor microenvironment. The phenotype of malignant plasma cells can be affected by lipid vulnerabilities, and these findings offer a new avenue for understanding this process. Additionally, they identify novel druggable pathways that have a major bearing on multiple myeloma care. |
| first_indexed | 2024-04-24T18:31:52Z |
| format | Article |
| id | doaj.art-034b00e2e0094c76857f74f6a2db5db8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-04-24T18:31:52Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-034b00e2e0094c76857f74f6a2db5db82024-03-27T13:22:37ZengMDPI AGBiomedicines2227-90592024-02-0112351410.3390/biomedicines12030514Protective Effects of High-Density Lipoprotein on Cancer Risk: Focus on Multiple MyelomaAlessandro Allegra0Giuseppe Murdaca1Giuseppe Mirabile2Sebastiano Gangemi3Hematology Unit, Department of Human Pathology in Adulthood and Childhood “Gaetano Barresi”, University of Messina, Via Consolare Valeria, 98125 Messina, ItalyDepartment of Internal Medicine, University of Genova, Viale Benedetto XV, 16132 Genova, ItalyHematology Unit, Department of Human Pathology in Adulthood and Childhood “Gaetano Barresi”, University of Messina, Via Consolare Valeria, 98125 Messina, ItalyAllergy and Clinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98125 Messina, ItalyLipid metabolism is intrinsically linked to tumorigenesis. And one of the most important characteristics of cancer is the modification of lipid metabolism and its correlation with oncogenic signaling pathways within the tumors. Because lipids function as signaling molecules, membrane structures, and energy sources, lipids are essential to the development of cancer. Above all, the proper immune response of tumor cells depends on the control of lipid metabolism. Changes in metabolism can modify systems that regulate carcinogenesis, such as inflammation, oxidative stress, and angiogenesis. The dependence of various malignancies on lipid metabolism varies. This review delves into the modifications to lipid metabolism that take place in cancer, specifically focusing on multiple myeloma. The review illustrates how changes in different lipid pathways impact the growth, survival, and drug-responsiveness of multiple myeloma cells, in addition to their interactions with other cells within the tumor microenvironment. The phenotype of malignant plasma cells can be affected by lipid vulnerabilities, and these findings offer a new avenue for understanding this process. Additionally, they identify novel druggable pathways that have a major bearing on multiple myeloma care.https://www.mdpi.com/2227-9059/12/3/514multiple myelomacancerlipid metabolismlow-density lipoproteinhigh-density lipoproteininflammation |
| spellingShingle | Alessandro Allegra Giuseppe Murdaca Giuseppe Mirabile Sebastiano Gangemi Protective Effects of High-Density Lipoprotein on Cancer Risk: Focus on Multiple Myeloma Biomedicines multiple myeloma cancer lipid metabolism low-density lipoprotein high-density lipoprotein inflammation |
| title | Protective Effects of High-Density Lipoprotein on Cancer Risk: Focus on Multiple Myeloma |
| title_full | Protective Effects of High-Density Lipoprotein on Cancer Risk: Focus on Multiple Myeloma |
| title_fullStr | Protective Effects of High-Density Lipoprotein on Cancer Risk: Focus on Multiple Myeloma |
| title_full_unstemmed | Protective Effects of High-Density Lipoprotein on Cancer Risk: Focus on Multiple Myeloma |
| title_short | Protective Effects of High-Density Lipoprotein on Cancer Risk: Focus on Multiple Myeloma |
| title_sort | protective effects of high density lipoprotein on cancer risk focus on multiple myeloma |
| topic | multiple myeloma cancer lipid metabolism low-density lipoprotein high-density lipoprotein inflammation |
| url | https://www.mdpi.com/2227-9059/12/3/514 |
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