Novel Targets for Treating Ischemia-Reperfusion Injury in the Liver
Liver ischemia-reperfusion injury (IRI) is a major complication of hemorrhagic shock, liver transplantation, and other liver surgeries. It is one of the leading causes for post-surgery hepatic dysfunction, always leading to morbidity and mortality. Several strategies, such as low-temperature reperfu...
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MDPI AG
2018-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/19/5/1302 |
| _version_ | 1811203592579710976 |
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| author | Weili Yang Ji Chen Yuhong Meng Zhenzhen Chen Jichun Yang |
| author_facet | Weili Yang Ji Chen Yuhong Meng Zhenzhen Chen Jichun Yang |
| author_sort | Weili Yang |
| collection | DOAJ |
| description | Liver ischemia-reperfusion injury (IRI) is a major complication of hemorrhagic shock, liver transplantation, and other liver surgeries. It is one of the leading causes for post-surgery hepatic dysfunction, always leading to morbidity and mortality. Several strategies, such as low-temperature reperfusion and ischemic preconditioning, are useful for ameliorating liver IRI in animal models. However, these methods are difficult to perform in clinical surgeries. It has been reported that the activation of peroxisome proliferator activated receptor gamma (PPARγ) protects the liver against IRI, but with unidentified direct target gene(s) and unclear mechanism(s). Recently, FAM3A, a direct target gene of PPARγ, had been shown to mediate PPARγ’s protective effects in liver IRI. Moreover, noncoding RNAs, including LncRNAs and miRNAs, had also been reported to play important roles in the process of hepatic IRI. This review briefly discussed the roles and mechanisms of several classes of important molecules, including PPARγ, FAM3A, miRNAs, and LncRNAs, in liver IRI. In particular, oral administration of PPARγ agonists before liver surgery or liver transplantation to activate hepatic FAM3A pathways holds great promise for attenuating human liver IRI. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T02:58:01Z |
| publishDate | 2018-04-01 |
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| spelling | doaj.art-034d6bbb51284e1089febb89a55735a22022-12-22T03:50:44ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-04-01195130210.3390/ijms19051302ijms19051302Novel Targets for Treating Ischemia-Reperfusion Injury in the LiverWeili Yang0Ji Chen1Yuhong Meng2Zhenzhen Chen3Jichun Yang4Department of Physiology and Pathophysiology, School of Basic Medical Sciences Key Laboratory of Molecular Cardiovascular Sciences of the Ministry of Education Center for Non-Coding RNA Medicine, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences Key Laboratory of Molecular Cardiovascular Sciences of the Ministry of Education Center for Non-Coding RNA Medicine, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences Key Laboratory of Molecular Cardiovascular Sciences of the Ministry of Education Center for Non-Coding RNA Medicine, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences Key Laboratory of Molecular Cardiovascular Sciences of the Ministry of Education Center for Non-Coding RNA Medicine, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences Key Laboratory of Molecular Cardiovascular Sciences of the Ministry of Education Center for Non-Coding RNA Medicine, Peking University Health Science Center, Beijing 100191, ChinaLiver ischemia-reperfusion injury (IRI) is a major complication of hemorrhagic shock, liver transplantation, and other liver surgeries. It is one of the leading causes for post-surgery hepatic dysfunction, always leading to morbidity and mortality. Several strategies, such as low-temperature reperfusion and ischemic preconditioning, are useful for ameliorating liver IRI in animal models. However, these methods are difficult to perform in clinical surgeries. It has been reported that the activation of peroxisome proliferator activated receptor gamma (PPARγ) protects the liver against IRI, but with unidentified direct target gene(s) and unclear mechanism(s). Recently, FAM3A, a direct target gene of PPARγ, had been shown to mediate PPARγ’s protective effects in liver IRI. Moreover, noncoding RNAs, including LncRNAs and miRNAs, had also been reported to play important roles in the process of hepatic IRI. This review briefly discussed the roles and mechanisms of several classes of important molecules, including PPARγ, FAM3A, miRNAs, and LncRNAs, in liver IRI. In particular, oral administration of PPARγ agonists before liver surgery or liver transplantation to activate hepatic FAM3A pathways holds great promise for attenuating human liver IRI.http://www.mdpi.com/1422-0067/19/5/1302liver ischemia-reperfusion injuryPPARγFAM3AmiRNALncRNA |
| spellingShingle | Weili Yang Ji Chen Yuhong Meng Zhenzhen Chen Jichun Yang Novel Targets for Treating Ischemia-Reperfusion Injury in the Liver International Journal of Molecular Sciences liver ischemia-reperfusion injury PPARγ FAM3A miRNA LncRNA |
| title | Novel Targets for Treating Ischemia-Reperfusion Injury in the Liver |
| title_full | Novel Targets for Treating Ischemia-Reperfusion Injury in the Liver |
| title_fullStr | Novel Targets for Treating Ischemia-Reperfusion Injury in the Liver |
| title_full_unstemmed | Novel Targets for Treating Ischemia-Reperfusion Injury in the Liver |
| title_short | Novel Targets for Treating Ischemia-Reperfusion Injury in the Liver |
| title_sort | novel targets for treating ischemia reperfusion injury in the liver |
| topic | liver ischemia-reperfusion injury PPARγ FAM3A miRNA LncRNA |
| url | http://www.mdpi.com/1422-0067/19/5/1302 |
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