Development and Validation of Rapid RP-HPLC and Green Second-Derivative UV Spectroscopic Methods for Simultaneous Quantification of Metformin and Remogliflozin in Formulation Using Experimental Design

Development and Validation of Rapid RP-HPLC and Green Second-Derivative UV Spectroscopic Methods for Simultaneous Quantification of Metformin and Remogliflozin in Formulation Using Experimental Design

Recently, a new formulation containing metformin HCl (MFH) and remogliflozin etabonate (RGE) has been approved for the management of diabetes mellitus. However, only one analytical method has been reported for the simultaneous determination of both the analytes. Therefore, the current study was desi...

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Bibliographic Details
Main Authors: Mahesh Attimarad, Rafea Elamin Elgack Elgorashe, Rajasekaran Subramaniam, Mohammed Monirul Islam, Katharigatta N. Venugopala, Sreeharsha Nagaraja, Abdulmalek Ahmed Balgoname
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Separations
Subjects:
metformin
remogliflozin
HPLC
box–behnken design
derivative spectroscopy
optimization
Online Access:https://www.mdpi.com/2297-8739/7/4/59

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