Prospective randomized open-label comparative study of immunogenicity after subunit and polymeric subunit influenza vaccines administration among mothers and infants
Pregnant women are risk group for influenza infection. Results of new subunit vaccines application have not been studied enough. Prospective, randomized, open-label comparative study of subunit (Agrippal) and polymeric subunit (Grippol plus) vaccines. 42 pairs of mothers-infants were participated in...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | http://dx.doi.org/10.1080/21645515.2018.1507585 |
| _version_ | 1797677452418351104 |
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| author | Mikhail Petrovich Kostinov Alexander Petrovich Cherdantsev Alexei Isaevich Kuselman Nelli Kimovna Akhmatova Aristitsa Mikhailovna Kostinova Elena Viktorovna Deryabina Evgeniia Olegovna Demina Anton Mikhailovich Kostinov |
| author_facet | Mikhail Petrovich Kostinov Alexander Petrovich Cherdantsev Alexei Isaevich Kuselman Nelli Kimovna Akhmatova Aristitsa Mikhailovna Kostinova Elena Viktorovna Deryabina Evgeniia Olegovna Demina Anton Mikhailovich Kostinov |
| author_sort | Mikhail Petrovich Kostinov |
| collection | DOAJ |
| description | Pregnant women are risk group for influenza infection. Results of new subunit vaccines application have not been studied enough. Prospective, randomized, open-label comparative study of subunit (Agrippal) and polymeric subunit (Grippol plus) vaccines. 42 pairs of mothers-infants were participated in the study. Protective antibodies (≥ 1:40) to different influenza strains were registered on day 1 after the birth on the same level as 53% of cases in pairs mothers-infants after immune adjuvant polymeric subunit and subunit vaccines administration. There were the same level of protective antibodies (AB) among mothers after 3 month, but transplacental antibodies decreased among infants and registered in the 13–22% cases of Grippol plus group and 31–43% cases in Agrippal S1 group. AB titre to influenza virus A/H1N1/pdm09 and A/H3N2/in pairs mothers-infants were the same in both groups in first days after birth, but AB levels to B strain were lower among infants without regard to vaccine. There is no difference in AB titres among infants of both groups at 3 month of age, but their levels were twice lower versus initial data. An immune adjuvant polymeric subunit as well as subunit vaccines application in pregnant women forms protective AB in pairs mothers-infants. |
| first_indexed | 2024-03-11T22:44:20Z |
| format | Article |
| id | doaj.art-034ff84808204dadaa9aa41330810b97 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:44:20Z |
| publishDate | 2018-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-034ff84808204dadaa9aa41330810b972023-09-22T08:38:23ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2018-12-0114122971297810.1080/21645515.2018.15075851507585Prospective randomized open-label comparative study of immunogenicity after subunit and polymeric subunit influenza vaccines administration among mothers and infantsMikhail Petrovich Kostinov0Alexander Petrovich Cherdantsev1Alexei Isaevich Kuselman2Nelli Kimovna Akhmatova3Aristitsa Mikhailovna Kostinova4Elena Viktorovna Deryabina5Evgeniia Olegovna Demina6Anton Mikhailovich Kostinov7FGBU NIIVS named after I.I. MechnikovFGBOU VPO Governmental University of UlyanovskFGBOU VPO Governmental University of UlyanovskFGBU NIIVS named after I.I. MechnikovNRC Institute of Immunology FMBA of RussiaFGBOU VPO Governmental University of UlyanovskFGBU NIIVS named after I.I. MechnikovLomonosov Moscow State UniversityPregnant women are risk group for influenza infection. Results of new subunit vaccines application have not been studied enough. Prospective, randomized, open-label comparative study of subunit (Agrippal) and polymeric subunit (Grippol plus) vaccines. 42 pairs of mothers-infants were participated in the study. Protective antibodies (≥ 1:40) to different influenza strains were registered on day 1 after the birth on the same level as 53% of cases in pairs mothers-infants after immune adjuvant polymeric subunit and subunit vaccines administration. There were the same level of protective antibodies (AB) among mothers after 3 month, but transplacental antibodies decreased among infants and registered in the 13–22% cases of Grippol plus group and 31–43% cases in Agrippal S1 group. AB titre to influenza virus A/H1N1/pdm09 and A/H3N2/in pairs mothers-infants were the same in both groups in first days after birth, but AB levels to B strain were lower among infants without regard to vaccine. There is no difference in AB titres among infants of both groups at 3 month of age, but their levels were twice lower versus initial data. An immune adjuvant polymeric subunit as well as subunit vaccines application in pregnant women forms protective AB in pairs mothers-infants.http://dx.doi.org/10.1080/21645515.2018.1507585vaccineinfluenzapolymeric-subunitpregnant women |
| spellingShingle | Mikhail Petrovich Kostinov Alexander Petrovich Cherdantsev Alexei Isaevich Kuselman Nelli Kimovna Akhmatova Aristitsa Mikhailovna Kostinova Elena Viktorovna Deryabina Evgeniia Olegovna Demina Anton Mikhailovich Kostinov Prospective randomized open-label comparative study of immunogenicity after subunit and polymeric subunit influenza vaccines administration among mothers and infants Human Vaccines & Immunotherapeutics vaccine influenza polymeric-subunit pregnant women |
| title | Prospective randomized open-label comparative study of immunogenicity after subunit and polymeric subunit influenza vaccines administration among mothers and infants |
| title_full | Prospective randomized open-label comparative study of immunogenicity after subunit and polymeric subunit influenza vaccines administration among mothers and infants |
| title_fullStr | Prospective randomized open-label comparative study of immunogenicity after subunit and polymeric subunit influenza vaccines administration among mothers and infants |
| title_full_unstemmed | Prospective randomized open-label comparative study of immunogenicity after subunit and polymeric subunit influenza vaccines administration among mothers and infants |
| title_short | Prospective randomized open-label comparative study of immunogenicity after subunit and polymeric subunit influenza vaccines administration among mothers and infants |
| title_sort | prospective randomized open label comparative study of immunogenicity after subunit and polymeric subunit influenza vaccines administration among mothers and infants |
| topic | vaccine influenza polymeric-subunit pregnant women |
| url | http://dx.doi.org/10.1080/21645515.2018.1507585 |
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