Production of Aldehydes by Biocatalysis
The production of aldehydes, highly reactive and toxic chemicals, brings specific challenges to biocatalytic processes. Absence of natural accumulation of aldehydes in microorganisms has led to a combination of in vitro and in vivo strategies for both, bulk and fine production. Advances in genetic a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/9/4949 |
| _version_ | 1797535051779407872 |
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| author | Veronika Kazimírová Martin Rebroš |
| author_facet | Veronika Kazimírová Martin Rebroš |
| author_sort | Veronika Kazimírová |
| collection | DOAJ |
| description | The production of aldehydes, highly reactive and toxic chemicals, brings specific challenges to biocatalytic processes. Absence of natural accumulation of aldehydes in microorganisms has led to a combination of in vitro and in vivo strategies for both, bulk and fine production. Advances in genetic and metabolic engineering and implementation of computational techniques led to the production of various enzymes with special requirements. Cofactor synthesis, post-translational modifications and structure engineering are applied to prepare active enzymes for one-step or cascade reactions. This review presents the highlights in biocatalytical production of aldehydes with the potential to shape future industrial applications. |
| first_indexed | 2024-03-10T11:39:05Z |
| format | Article |
| id | doaj.art-03523ceec0aa43faad16307d00ca8319 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:39:05Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-03523ceec0aa43faad16307d00ca83192023-11-21T18:37:03ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-01229494910.3390/ijms22094949Production of Aldehydes by BiocatalysisVeronika Kazimírová0Martin Rebroš1Institute of Biotechnology, Faculty of Chemical and Food Technology, Slovak University of Technology, 811 07 Bratislava, SlovakiaInstitute of Biotechnology, Faculty of Chemical and Food Technology, Slovak University of Technology, 811 07 Bratislava, SlovakiaThe production of aldehydes, highly reactive and toxic chemicals, brings specific challenges to biocatalytic processes. Absence of natural accumulation of aldehydes in microorganisms has led to a combination of in vitro and in vivo strategies for both, bulk and fine production. Advances in genetic and metabolic engineering and implementation of computational techniques led to the production of various enzymes with special requirements. Cofactor synthesis, post-translational modifications and structure engineering are applied to prepare active enzymes for one-step or cascade reactions. This review presents the highlights in biocatalytical production of aldehydes with the potential to shape future industrial applications.https://www.mdpi.com/1422-0067/22/9/4949biomaterialsgene expression/regulationgreen chemistrymetabolismnatural productsprotein engineering |
| spellingShingle | Veronika Kazimírová Martin Rebroš Production of Aldehydes by Biocatalysis International Journal of Molecular Sciences biomaterials gene expression/regulation green chemistry metabolism natural products protein engineering |
| title | Production of Aldehydes by Biocatalysis |
| title_full | Production of Aldehydes by Biocatalysis |
| title_fullStr | Production of Aldehydes by Biocatalysis |
| title_full_unstemmed | Production of Aldehydes by Biocatalysis |
| title_short | Production of Aldehydes by Biocatalysis |
| title_sort | production of aldehydes by biocatalysis |
| topic | biomaterials gene expression/regulation green chemistry metabolism natural products protein engineering |
| url | https://www.mdpi.com/1422-0067/22/9/4949 |
| work_keys_str_mv | AT veronikakazimirova productionofaldehydesbybiocatalysis AT martinrebros productionofaldehydesbybiocatalysis |