Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases
AbstractThe conventional treatment methods used for the management of autoimmune diseases (ADs) have limited efficacy and also exhibit significant side effects. Thus, identification of novel strategies to improve the efficacy and safety of ADs treatment is urgently required. Overactivated immune res...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2023.2289846 |
| _version_ | 1797260977193877504 |
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| author | Manxiang Wu Chengyuan Hong Chunjuan Shen Dong Xie Tianxiang Chen Aiguo Wu Qiang Li |
| author_facet | Manxiang Wu Chengyuan Hong Chunjuan Shen Dong Xie Tianxiang Chen Aiguo Wu Qiang Li |
| author_sort | Manxiang Wu |
| collection | DOAJ |
| description | AbstractThe conventional treatment methods used for the management of autoimmune diseases (ADs) have limited efficacy and also exhibit significant side effects. Thus, identification of novel strategies to improve the efficacy and safety of ADs treatment is urgently required. Overactivated immune response and oxidative stress are common characteristics associated with ADs. Polydopamine (PDA), as a polymer material with good antioxidant and photothermal conversion properties, has displayed useful application potential against ADs. In addition, PDA possesses good biosafety, simple preparation, and easy functionalization, which is conducive for the pharmacological development of PDA nanomaterials with clinical transformation prospects. Here, we have first reviewed the preparation of PDA, the different functional integration strategies of PDA-based biomaterials, and their potential applications in ADs. Next, the mechanism of action of PDA in ADs has been elaborated in detail. Finally, the application opportunities and challenges linked with PDA nanomaterials for ADs treatment are discussed. This review is contributed to design reasonable and effective PDA nanomaterials for the diagnosis and treatment of ADs. |
| first_indexed | 2024-03-08T23:31:20Z |
| format | Article |
| id | doaj.art-03534167d76c4eb3a518859e92b114bb |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-04-24T23:33:53Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
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| series | Drug Delivery |
| spelling | doaj.art-03534167d76c4eb3a518859e92b114bb2024-03-15T14:22:17ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642023-12-0130110.1080/10717544.2023.2289846Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseasesManxiang Wu0Chengyuan Hong1Chunjuan Shen2Dong Xie3Tianxiang Chen4Aiguo Wu5Qiang Li6Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo, ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo, ChinaCenter for Reproductive Medicine, Jiaxing University Affilated Maternity and Child Hospital, Jiaxing, P. R. ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo, ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo, ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo, ChinaDepartment of Radiology, The Affiliated People’s Hospital of Ningbo University, Ningbo, P. R. ChinaAbstractThe conventional treatment methods used for the management of autoimmune diseases (ADs) have limited efficacy and also exhibit significant side effects. Thus, identification of novel strategies to improve the efficacy and safety of ADs treatment is urgently required. Overactivated immune response and oxidative stress are common characteristics associated with ADs. Polydopamine (PDA), as a polymer material with good antioxidant and photothermal conversion properties, has displayed useful application potential against ADs. In addition, PDA possesses good biosafety, simple preparation, and easy functionalization, which is conducive for the pharmacological development of PDA nanomaterials with clinical transformation prospects. Here, we have first reviewed the preparation of PDA, the different functional integration strategies of PDA-based biomaterials, and their potential applications in ADs. Next, the mechanism of action of PDA in ADs has been elaborated in detail. Finally, the application opportunities and challenges linked with PDA nanomaterials for ADs treatment are discussed. This review is contributed to design reasonable and effective PDA nanomaterials for the diagnosis and treatment of ADs.https://www.tandfonline.com/doi/10.1080/10717544.2023.2289846Polydopamineautoimmune diseasesphotothermal therapyimmunomodulationantioxidant |
| spellingShingle | Manxiang Wu Chengyuan Hong Chunjuan Shen Dong Xie Tianxiang Chen Aiguo Wu Qiang Li Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases Drug Delivery Polydopamine autoimmune diseases photothermal therapy immunomodulation antioxidant |
| title | Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases |
| title_full | Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases |
| title_fullStr | Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases |
| title_full_unstemmed | Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases |
| title_short | Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases |
| title_sort | polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases |
| topic | Polydopamine autoimmune diseases photothermal therapy immunomodulation antioxidant |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2023.2289846 |
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