Exposure to 3-Nitropropionic Acid Mitochondrial Toxin Induces Tau Pathology in Tangle-Mouse Model and in Wild Type-Mice

Exposure to 3-Nitropropionic Acid Mitochondrial Toxin Induces Tau Pathology in Tangle-Mouse Model and in Wild Type-Mice

Oxidative stress, particularly of mitochondrial origin, plays an important role in the pathogenesis of neurodegenerative disorders, including Alzheimer’s disease (AD) and other tauopathies. Controversies regarding the responses of tau phosphorylation state to various stimuli causing oxidative stress...

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Bibliographic Details
Main Authors: Inbal Lahiani-Cohen, Olga Touloumi, Roza Lagoudaki, Nikolaos Grigoriadis, Hanna Rosenmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
tau protein
neurofibrillary tangles
tauopathy
mitochondria
mitochondrial dysfunction
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00321/full

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