Exoenzyme T Plays a Pivotal Role in the IFN-γ Production after Pseudomonas Challenge in IL-12 Primed Natural Killer Cells

Exoenzyme T Plays a Pivotal Role in the IFN-γ Production after Pseudomonas Challenge in IL-12 Primed Natural Killer Cells

Pseudomonas aeruginosa (PA) expresses the type III secretion system (T3SS) and effector exoenzymes that interfere with intracellular pathways. Natural killer (NK) cells play a key role in antibacterial immunity and their activation is highly dependent on IL-12 produced by myeloid cells. We studied P...

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Bibliographic Details
Main Authors: Mickael Vourc’h, Antoine Roquilly, Alexis Broquet, Gaelle David, Philippe Hulin, Cedric Jacqueline, Jocelyne Caillon, Christelle Retiere, Karim Asehnoune
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
natural killer cells
Pseudomonas aeruginosa
type III secretion system
innate lymphoid cells
IL-12
interferon-gamma
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01283/full

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