Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis
Objectives: Existing findings regarding the relationship between comorbidities and the severity of coronavirus disease 2019 (COVID-19) are inconsistent and insufficient. The aim of this study was to evaluate the association between different comorbidities and the severity of COVID-19. Methods: The P...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220305725 |
| _version_ | 1818255047104921600 |
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| author | Yue Zhou Qing Yang Jingwei Chi Bingzi Dong Wenshan Lv Liyan Shen Yangang Wang |
| author_facet | Yue Zhou Qing Yang Jingwei Chi Bingzi Dong Wenshan Lv Liyan Shen Yangang Wang |
| author_sort | Yue Zhou |
| collection | DOAJ |
| description | Objectives: Existing findings regarding the relationship between comorbidities and the severity of coronavirus disease 2019 (COVID-19) are inconsistent and insufficient. The aim of this study was to evaluate the association between different comorbidities and the severity of COVID-19. Methods: The PubMed, Embase, and Cochrane Library databases were searched to identify studies reporting the rates of comorbidities in COVID-19 patients with severe/fatal outcomes. Subgroup analyses were conducted according to disease severity and the country of residence. Odds ratios (OR) with 95% confidence intervals (CI) were pooled using random-effects models. Results: A total of 34 eligible studies were identified. In patients with severe/fatal COVID-19, the most prevalent chronic comorbidities were obesity (42%, 95% CI 34–49%) and hypertension (40%, 95% CI 35–45%), followed by diabetes (17%, 95% CI 15–20%), cardiovascular disease (13%, 95% CI 11–15%), respiratory disease (8%, 95% CI 6–10%), cerebrovascular disease (6%, 95% CI 4–8%), malignancy (4%, 95% CI 3–6%), kidney disease (3%, 95% CI 2–4%), and liver disease (2%, 95% CI 1–3%). In order of the prediction, the pooled ORs of the comorbidities in patients with severe or fatal COVID-19 when compared to patients with non-severe/fatal COVID-19 were as follows: chronic respiratory disease, OR 3.56 (95% CI 2.87–4.41); hypertension, OR 3.17 (95% CI 2.46–4.08); cardiovascular disease, OR 3.13 (95% CI 2.65–3.70); kidney disease, OR 3.02 (95% CI 2.23–4.08); cerebrovascular disease, OR 2.74 (95% CI 1.59–4.74); malignancy, OR 2.73 (95% CI 1.73–4.21); diabetes, OR 2.63 (95% CI 2.08–3.33); and obesity, OR 1.72 (95% CI 1.04–2.85). No correlation was observed between liver disease and COVID-19 aggravation (OR 1.54, 95% CI 0.95–2.49). Conclusions: Chronic comorbidities, including obesity, hypertension, diabetes, cardiovascular disease, cerebrovascular disease, respiratory disease, kidney disease, and malignancy are clinical risk factors for a severe or fatal outcome associated with COVID-19, with obesity being the most prevalent and respiratory disease being the most strongly predictive. Knowledge of these risk factors could help clinicians better identify and manage the high-risk populations. |
| first_indexed | 2024-12-12T17:05:39Z |
| format | Article |
| id | doaj.art-035622fa2ce24ff98cee55ad768a2cdc |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-12T17:05:39Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-035622fa2ce24ff98cee55ad768a2cdc2022-12-22T00:18:01ZengElsevierInternational Journal of Infectious Diseases1201-97122020-10-01994756Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysisYue Zhou0Qing Yang1Jingwei Chi2Bingzi Dong3Wenshan Lv4Liyan Shen5Yangang Wang6Department of Endocrinology, Affiliated Hospital of Medical College Qingdao University, Qingdao, ChinaInstitute of Biophysics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing, ChinaDepartment of Endocrinology, Affiliated Hospital of Medical College Qingdao University, Qingdao, ChinaDepartment of Endocrinology, Affiliated Hospital of Medical College Qingdao University, Qingdao, ChinaDepartment of Endocrinology, Affiliated Hospital of Medical College Qingdao University, Qingdao, ChinaDepartment of Endocrinology, Affiliated Hospital of Medical College Qingdao University, Qingdao, China; Corresponding authors at: Department of Endocrinology, Affiliated Hospital of Medical College Qingdao University, Qingdao, Shandong Province, 266003, China.Department of Endocrinology, Affiliated Hospital of Medical College Qingdao University, Qingdao, China; Corresponding authors at: Department of Endocrinology, Affiliated Hospital of Medical College Qingdao University, Qingdao, Shandong Province, 266003, China.Objectives: Existing findings regarding the relationship between comorbidities and the severity of coronavirus disease 2019 (COVID-19) are inconsistent and insufficient. The aim of this study was to evaluate the association between different comorbidities and the severity of COVID-19. Methods: The PubMed, Embase, and Cochrane Library databases were searched to identify studies reporting the rates of comorbidities in COVID-19 patients with severe/fatal outcomes. Subgroup analyses were conducted according to disease severity and the country of residence. Odds ratios (OR) with 95% confidence intervals (CI) were pooled using random-effects models. Results: A total of 34 eligible studies were identified. In patients with severe/fatal COVID-19, the most prevalent chronic comorbidities were obesity (42%, 95% CI 34–49%) and hypertension (40%, 95% CI 35–45%), followed by diabetes (17%, 95% CI 15–20%), cardiovascular disease (13%, 95% CI 11–15%), respiratory disease (8%, 95% CI 6–10%), cerebrovascular disease (6%, 95% CI 4–8%), malignancy (4%, 95% CI 3–6%), kidney disease (3%, 95% CI 2–4%), and liver disease (2%, 95% CI 1–3%). In order of the prediction, the pooled ORs of the comorbidities in patients with severe or fatal COVID-19 when compared to patients with non-severe/fatal COVID-19 were as follows: chronic respiratory disease, OR 3.56 (95% CI 2.87–4.41); hypertension, OR 3.17 (95% CI 2.46–4.08); cardiovascular disease, OR 3.13 (95% CI 2.65–3.70); kidney disease, OR 3.02 (95% CI 2.23–4.08); cerebrovascular disease, OR 2.74 (95% CI 1.59–4.74); malignancy, OR 2.73 (95% CI 1.73–4.21); diabetes, OR 2.63 (95% CI 2.08–3.33); and obesity, OR 1.72 (95% CI 1.04–2.85). No correlation was observed between liver disease and COVID-19 aggravation (OR 1.54, 95% CI 0.95–2.49). Conclusions: Chronic comorbidities, including obesity, hypertension, diabetes, cardiovascular disease, cerebrovascular disease, respiratory disease, kidney disease, and malignancy are clinical risk factors for a severe or fatal outcome associated with COVID-19, with obesity being the most prevalent and respiratory disease being the most strongly predictive. Knowledge of these risk factors could help clinicians better identify and manage the high-risk populations.http://www.sciencedirect.com/science/article/pii/S1201971220305725ComorbiditySevereICU admissionFatalityCOVID-19 |
| spellingShingle | Yue Zhou Qing Yang Jingwei Chi Bingzi Dong Wenshan Lv Liyan Shen Yangang Wang Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis International Journal of Infectious Diseases Comorbidity Severe ICU admission Fatality COVID-19 |
| title | Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis |
| title_full | Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis |
| title_fullStr | Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis |
| title_full_unstemmed | Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis |
| title_short | Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis |
| title_sort | comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019 a systematic review and meta analysis |
| topic | Comorbidity Severe ICU admission Fatality COVID-19 |
| url | http://www.sciencedirect.com/science/article/pii/S1201971220305725 |
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