Chemotherapy combined with dendritic cell vaccine and cytokine-induced killer cells in the treatment of colorectal carcinoma: a meta-analysis
Xiuling Zhou,1,* Xiangqiong Mo,2,* Junlan Qiu,3,* Jingjing Zhao,4 Shuncong Wang,1 Cuiling Zhou,1 Yonghui Su,2 Zhong Lin,1 Haiqing Ma1 1Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China; 2Department of General Surgery, The Fifth Affiliate...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-11-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/chemotherapy-combined-with-dendritic-cell-vaccine-and-cytokine-induced-peer-reviewed-article-CMAR |
| _version_ | 1819059015451148288 |
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| author | Zhou X Mo X Qiu J Zhao J Wang S Zhou C Su Y Lin Z Ma H |
| author_facet | Zhou X Mo X Qiu J Zhao J Wang S Zhou C Su Y Lin Z Ma H |
| author_sort | Zhou X |
| collection | DOAJ |
| description | Xiuling Zhou,1,* Xiangqiong Mo,2,* Junlan Qiu,3,* Jingjing Zhao,4 Shuncong Wang,1 Cuiling Zhou,1 Yonghui Su,2 Zhong Lin,1 Haiqing Ma1 1Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China; 2Department of General Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China; 3Department of Oncology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Science & Technology Town Hospital, Jiangsu 215153, China; 4Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China *These authors contributed equally to this work Aim: To investigate the efficacy and safety of dendritic cell (DC) vaccine combined with cytokine-induced killer (CIK) cell therapy in colorectal carcinoma (CRC). Patients and methods: PubMed, Embase, and Cochrane Library databases were searched systematically for clinical trials of DC vaccine and CIK cell therapy combined with chemotherapy for CRC. The primary and secondary endpoints were overall survival (OS) and disease-free survival (DFS), respectively. Pooled risk ratios were used to assess the treatment efficacy. Both random and fixed effects models were used for statistical analysis. The study population consisted of 871 CRC patients enrolled in four trials. Results: OS and DFS were significantly improved in patients who received chemotherapy combined with DC vaccine and CIK cells, and no severe adverse events were shown. Conclusions: The study demonstrated that the addition of DC vaccine and CIK cell therapy to chemotherapy is feasible and effective in patients with CRC. Keywords: adoptive cellular therapy, immunotherapy, dendritic cell vaccine, cytokine-induced killer cell, overall survival, disease-free survival, colorectal carcinoma |
| first_indexed | 2024-12-21T14:04:23Z |
| format | Article |
| id | doaj.art-0356ec7b86e54fd08d6cc5c8c9a0a9ee |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-21T14:04:23Z |
| publishDate | 2018-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-0356ec7b86e54fd08d6cc5c8c9a0a9ee2022-12-21T19:01:16ZengDove Medical PressCancer Management and Research1179-13222018-11-01Volume 105363537242049Chemotherapy combined with dendritic cell vaccine and cytokine-induced killer cells in the treatment of colorectal carcinoma: a meta-analysisZhou XMo XQiu JZhao JWang SZhou CSu YLin ZMa HXiuling Zhou,1,* Xiangqiong Mo,2,* Junlan Qiu,3,* Jingjing Zhao,4 Shuncong Wang,1 Cuiling Zhou,1 Yonghui Su,2 Zhong Lin,1 Haiqing Ma1 1Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China; 2Department of General Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China; 3Department of Oncology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Science & Technology Town Hospital, Jiangsu 215153, China; 4Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China *These authors contributed equally to this work Aim: To investigate the efficacy and safety of dendritic cell (DC) vaccine combined with cytokine-induced killer (CIK) cell therapy in colorectal carcinoma (CRC). Patients and methods: PubMed, Embase, and Cochrane Library databases were searched systematically for clinical trials of DC vaccine and CIK cell therapy combined with chemotherapy for CRC. The primary and secondary endpoints were overall survival (OS) and disease-free survival (DFS), respectively. Pooled risk ratios were used to assess the treatment efficacy. Both random and fixed effects models were used for statistical analysis. The study population consisted of 871 CRC patients enrolled in four trials. Results: OS and DFS were significantly improved in patients who received chemotherapy combined with DC vaccine and CIK cells, and no severe adverse events were shown. Conclusions: The study demonstrated that the addition of DC vaccine and CIK cell therapy to chemotherapy is feasible and effective in patients with CRC. Keywords: adoptive cellular therapy, immunotherapy, dendritic cell vaccine, cytokine-induced killer cell, overall survival, disease-free survival, colorectal carcinomahttps://www.dovepress.com/chemotherapy-combined-with-dendritic-cell-vaccine-and-cytokine-induced-peer-reviewed-article-CMARcolorectal carcinomaimmunotherapydendritic cell vaccine; cytokine-induced killer celloverall survivaldisease-free survival |
| spellingShingle | Zhou X Mo X Qiu J Zhao J Wang S Zhou C Su Y Lin Z Ma H Chemotherapy combined with dendritic cell vaccine and cytokine-induced killer cells in the treatment of colorectal carcinoma: a meta-analysis Cancer Management and Research colorectal carcinoma immunotherapy dendritic cell vaccine; cytokine-induced killer cell overall survival disease-free survival |
| title | Chemotherapy combined with dendritic cell vaccine and cytokine-induced killer cells in the treatment of colorectal carcinoma: a meta-analysis |
| title_full | Chemotherapy combined with dendritic cell vaccine and cytokine-induced killer cells in the treatment of colorectal carcinoma: a meta-analysis |
| title_fullStr | Chemotherapy combined with dendritic cell vaccine and cytokine-induced killer cells in the treatment of colorectal carcinoma: a meta-analysis |
| title_full_unstemmed | Chemotherapy combined with dendritic cell vaccine and cytokine-induced killer cells in the treatment of colorectal carcinoma: a meta-analysis |
| title_short | Chemotherapy combined with dendritic cell vaccine and cytokine-induced killer cells in the treatment of colorectal carcinoma: a meta-analysis |
| title_sort | chemotherapy combined with dendritic cell vaccine and cytokine induced killer cells in the treatment of colorectal carcinoma a meta analysis |
| topic | colorectal carcinoma immunotherapy dendritic cell vaccine; cytokine-induced killer cell overall survival disease-free survival |
| url | https://www.dovepress.com/chemotherapy-combined-with-dendritic-cell-vaccine-and-cytokine-induced-peer-reviewed-article-CMAR |
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