Natural products modulate cell apoptosis: a promising way for treating endometrial cancer
Endometrial cancer (EC) is a prevalent epithelial malignancy in the uterine corpus’s endometrium and myometrium. Regulating apoptosis of endometrial cancer cells has been a promising approach for treating EC. Recent in-vitro and in-vivo studies show that numerous extracts and monomers from natural p...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1209412/full |
| _version_ | 1827931070549458944 |
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| author | Xin Zhou Yiwei Zeng Runchen Zheng Yuemei Wang Tao Li Shanshan Song Su Zhang Jinzhu Huang Jinzhu Huang Yulan Ren |
| author_facet | Xin Zhou Yiwei Zeng Runchen Zheng Yuemei Wang Tao Li Shanshan Song Su Zhang Jinzhu Huang Jinzhu Huang Yulan Ren |
| author_sort | Xin Zhou |
| collection | DOAJ |
| description | Endometrial cancer (EC) is a prevalent epithelial malignancy in the uterine corpus’s endometrium and myometrium. Regulating apoptosis of endometrial cancer cells has been a promising approach for treating EC. Recent in-vitro and in-vivo studies show that numerous extracts and monomers from natural products have pro-apoptotic properties in EC. Therefore, we have reviewed the current studies regarding natural products in modulating the apoptosis of EC cells and summarized their potential mechanisms. The potential signaling pathways include the mitochondria-dependent apoptotic pathway, endoplasmic reticulum stress (ERS) mediated apoptotic pathway, the mitogen-activated protein kinase (MAPK) mediated apoptotic pathway, NF-κB-mediated apoptotic pathway, PI3K/AKT/mTOR mediated apoptotic pathway, the p21-mediated apoptotic pathway, and other reported pathways. This review focuses on the importance of natural products in treating EC and provides a foundation for developing natural products-based anti-EC agents. |
| first_indexed | 2024-03-13T06:45:56Z |
| format | Article |
| id | doaj.art-0357037094e44003a61b69036c19430f |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-13T06:45:56Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-0357037094e44003a61b69036c19430f2023-06-08T05:35:48ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-06-011410.3389/fphar.2023.12094121209412Natural products modulate cell apoptosis: a promising way for treating endometrial cancerXin Zhou0Yiwei Zeng1Runchen Zheng2Yuemei Wang3Tao Li4Shanshan Song5Su Zhang6Jinzhu Huang7Jinzhu Huang8Yulan Ren9School of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Gynecology, School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaEndometrial cancer (EC) is a prevalent epithelial malignancy in the uterine corpus’s endometrium and myometrium. Regulating apoptosis of endometrial cancer cells has been a promising approach for treating EC. Recent in-vitro and in-vivo studies show that numerous extracts and monomers from natural products have pro-apoptotic properties in EC. Therefore, we have reviewed the current studies regarding natural products in modulating the apoptosis of EC cells and summarized their potential mechanisms. The potential signaling pathways include the mitochondria-dependent apoptotic pathway, endoplasmic reticulum stress (ERS) mediated apoptotic pathway, the mitogen-activated protein kinase (MAPK) mediated apoptotic pathway, NF-κB-mediated apoptotic pathway, PI3K/AKT/mTOR mediated apoptotic pathway, the p21-mediated apoptotic pathway, and other reported pathways. This review focuses on the importance of natural products in treating EC and provides a foundation for developing natural products-based anti-EC agents.https://www.frontiersin.org/articles/10.3389/fphar.2023.1209412/fullnatural productsendometrial cancerapoptosissignal pathwayanti-cancer effects |
| spellingShingle | Xin Zhou Yiwei Zeng Runchen Zheng Yuemei Wang Tao Li Shanshan Song Su Zhang Jinzhu Huang Jinzhu Huang Yulan Ren Natural products modulate cell apoptosis: a promising way for treating endometrial cancer Frontiers in Pharmacology natural products endometrial cancer apoptosis signal pathway anti-cancer effects |
| title | Natural products modulate cell apoptosis: a promising way for treating endometrial cancer |
| title_full | Natural products modulate cell apoptosis: a promising way for treating endometrial cancer |
| title_fullStr | Natural products modulate cell apoptosis: a promising way for treating endometrial cancer |
| title_full_unstemmed | Natural products modulate cell apoptosis: a promising way for treating endometrial cancer |
| title_short | Natural products modulate cell apoptosis: a promising way for treating endometrial cancer |
| title_sort | natural products modulate cell apoptosis a promising way for treating endometrial cancer |
| topic | natural products endometrial cancer apoptosis signal pathway anti-cancer effects |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1209412/full |
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