Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis.
The aim of this study was to analyse the clinical characteristics of acute pancreatitis (AP) in a prospectively collected, large, multicentre cohort and to validate the major recommendations in the IAP/APA evidence-based guidelines for the management of AP.Eighty-six different clinical parameters we...
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Public Library of Science (PLoS)
2016-01-01
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author | Andrea Párniczky Balázs Kui Andrea Szentesi Anita Balázs Ákos Szűcs Dóra Mosztbacher József Czimmer Patrícia Sarlós Judit Bajor Szilárd Gódi Áron Vincze Anita Illés Imre Szabó Gabriella Pár Tamás Takács László Czakó Zoltán Szepes Zoltán Rakonczay Ferenc Izbéki Judit Gervain Adrienn Halász János Novák Stefan Crai István Hritz Csaba Góg János Sümegi Petra Golovics Márta Varga Barnabás Bod József Hamvas Mónika Varga-Müller Zsuzsanna Papp Miklós Sahin-Tóth Péter Hegyi Hungarian Pancreatic Study Group |
author_facet | Andrea Párniczky Balázs Kui Andrea Szentesi Anita Balázs Ákos Szűcs Dóra Mosztbacher József Czimmer Patrícia Sarlós Judit Bajor Szilárd Gódi Áron Vincze Anita Illés Imre Szabó Gabriella Pár Tamás Takács László Czakó Zoltán Szepes Zoltán Rakonczay Ferenc Izbéki Judit Gervain Adrienn Halász János Novák Stefan Crai István Hritz Csaba Góg János Sümegi Petra Golovics Márta Varga Barnabás Bod József Hamvas Mónika Varga-Müller Zsuzsanna Papp Miklós Sahin-Tóth Péter Hegyi Hungarian Pancreatic Study Group |
author_sort | Andrea Párniczky |
collection | DOAJ |
description | The aim of this study was to analyse the clinical characteristics of acute pancreatitis (AP) in a prospectively collected, large, multicentre cohort and to validate the major recommendations in the IAP/APA evidence-based guidelines for the management of AP.Eighty-six different clinical parameters were collected using an electronic clinical research form designed by the Hungarian Pancreatic Study Group.600 adult patients diagnosed with AP were prospectively enrolled from 17 Hungarian centres over a two-year period from 1 January 2013.With respect to aetiology, biliary and alcoholic pancreatitis represented the two most common forms of AP. The prevalence of biliary AP was higher in women, whereas alcoholic AP was more common in men. Hyperlipidaemia was a risk factor for severity, lack of serum enzyme elevation posed a risk for severe AP, and lack of abdominal pain at admission demonstrated a risk for mortality. Abdominal tenderness developed in all the patients with severe AP, while lack of abdominal tenderness was a favourable sign for mortality. Importantly, lung injury at admission was associated with mortality. With regard to laboratory parameters, white blood cell count and CRP were the two most sensitive indicators for severe AP. The most common local complication was peripancreatic fluid, whereas the most common distant organ failure in severe AP was lung injury. Deviation from the recommendations in the IAP/APA evidence-based guidelines on fluid replacement, enteral nutrition and timing of interventions increased severity and mortality.Analysis of a large, nationwide, prospective cohort of AP cases allowed for the identification of important determinants of severity and mortality. Evidence-based guidelines should be observed rigorously to improve outcomes in AP. |
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language | English |
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spelling | doaj.art-0359a5a1878c4574a1c9f824ab24dfba2022-12-22T03:46:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011110e016530910.1371/journal.pone.0165309Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis.Andrea PárniczkyBalázs KuiAndrea SzentesiAnita BalázsÁkos SzűcsDóra MosztbacherJózsef CzimmerPatrícia SarlósJudit BajorSzilárd GódiÁron VinczeAnita IllésImre SzabóGabriella PárTamás TakácsLászló CzakóZoltán SzepesZoltán RakonczayFerenc IzbékiJudit GervainAdrienn HalászJános NovákStefan CraiIstván HritzCsaba GógJános SümegiPetra GolovicsMárta VargaBarnabás BodJózsef HamvasMónika Varga-MüllerZsuzsanna PappMiklós Sahin-TóthPéter HegyiHungarian Pancreatic Study GroupThe aim of this study was to analyse the clinical characteristics of acute pancreatitis (AP) in a prospectively collected, large, multicentre cohort and to validate the major recommendations in the IAP/APA evidence-based guidelines for the management of AP.Eighty-six different clinical parameters were collected using an electronic clinical research form designed by the Hungarian Pancreatic Study Group.600 adult patients diagnosed with AP were prospectively enrolled from 17 Hungarian centres over a two-year period from 1 January 2013.With respect to aetiology, biliary and alcoholic pancreatitis represented the two most common forms of AP. The prevalence of biliary AP was higher in women, whereas alcoholic AP was more common in men. Hyperlipidaemia was a risk factor for severity, lack of serum enzyme elevation posed a risk for severe AP, and lack of abdominal pain at admission demonstrated a risk for mortality. Abdominal tenderness developed in all the patients with severe AP, while lack of abdominal tenderness was a favourable sign for mortality. Importantly, lung injury at admission was associated with mortality. With regard to laboratory parameters, white blood cell count and CRP were the two most sensitive indicators for severe AP. The most common local complication was peripancreatic fluid, whereas the most common distant organ failure in severe AP was lung injury. Deviation from the recommendations in the IAP/APA evidence-based guidelines on fluid replacement, enteral nutrition and timing of interventions increased severity and mortality.Analysis of a large, nationwide, prospective cohort of AP cases allowed for the identification of important determinants of severity and mortality. Evidence-based guidelines should be observed rigorously to improve outcomes in AP.http://europepmc.org/articles/PMC5087847?pdf=render |
spellingShingle | Andrea Párniczky Balázs Kui Andrea Szentesi Anita Balázs Ákos Szűcs Dóra Mosztbacher József Czimmer Patrícia Sarlós Judit Bajor Szilárd Gódi Áron Vincze Anita Illés Imre Szabó Gabriella Pár Tamás Takács László Czakó Zoltán Szepes Zoltán Rakonczay Ferenc Izbéki Judit Gervain Adrienn Halász János Novák Stefan Crai István Hritz Csaba Góg János Sümegi Petra Golovics Márta Varga Barnabás Bod József Hamvas Mónika Varga-Müller Zsuzsanna Papp Miklós Sahin-Tóth Péter Hegyi Hungarian Pancreatic Study Group Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis. PLoS ONE |
title | Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis. |
title_full | Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis. |
title_fullStr | Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis. |
title_full_unstemmed | Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis. |
title_short | Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis. |
title_sort | prospective multicentre nationwide clinical data from 600 cases of acute pancreatitis |
url | http://europepmc.org/articles/PMC5087847?pdf=render |
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