Hepatitis C virus genotypes among multiply transfused hemoglobinopathy patients from Northern Iraq
Background and Aim: Owing to the scarcity of data on hepatitis C virus (HCV) genotypes in Iraq and due to their epidemiological as well as therapy implications, this study was initiated aiming at determining these genotypes in Northern Iraq. Materials and Methods: A total of 70 HCV antibody positive...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2014;volume=8;issue=1;spage=32;epage=34;aulast=Othman |
| _version_ | 1811303722309910528 |
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| author | Adil A Othman Adil A Eissa Raji D Markous Bayram D Ahmed Nasir A. S Al-Allawi |
| author_facet | Adil A Othman Adil A Eissa Raji D Markous Bayram D Ahmed Nasir A. S Al-Allawi |
| author_sort | Adil A Othman |
| collection | DOAJ |
| description | Background and Aim: Owing to the scarcity of data on hepatitis C virus (HCV) genotypes in Iraq and due to their epidemiological as well as therapy implications, this study was initiated aiming at determining these genotypes in Northern Iraq. Materials and Methods: A total of 70 HCV antibody positive multi transfused patients with hemoglobinopathies, who had detectable HCV ribonucleic acid, were recruited for genotyping using genotype-specific nested polymerase chain reaction. Results: The most frequent genotype detected was genotype 4 (52.9%) followed by 3a (17.1%), 1b (12.9%) and 1a (1.4%), while mixed genotypes (4 with either 3a or 1b) were detected in 7.1%. Conclusion: The predominance of genotype 4 is similar to other studies from surrounding Eastern Mediterranean Arab countries and to the only earlier study from central Iraq, however the significant high proportion of 3a and scarcity of 1a, are in contrast to the latter study and may be explainable by the differing population interactions in this part of Iraq. This study complements previous studies from Eastern Mediterranean region and demonstrates relative heterogeneity of HCV genotype distribution within Iraq and should trigger further studies in other parts of the country. |
| first_indexed | 2024-04-13T07:53:04Z |
| format | Article |
| id | doaj.art-035a7a236c2d40c48c18662891bbde50 |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-04-13T07:53:04Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-035a7a236c2d40c48c18662891bbde502022-12-22T02:55:29ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652014-01-0181323410.4103/0973-6247.126687Hepatitis C virus genotypes among multiply transfused hemoglobinopathy patients from Northern IraqAdil A OthmanAdil A EissaRaji D MarkousBayram D AhmedNasir A. S Al-AllawiBackground and Aim: Owing to the scarcity of data on hepatitis C virus (HCV) genotypes in Iraq and due to their epidemiological as well as therapy implications, this study was initiated aiming at determining these genotypes in Northern Iraq. Materials and Methods: A total of 70 HCV antibody positive multi transfused patients with hemoglobinopathies, who had detectable HCV ribonucleic acid, were recruited for genotyping using genotype-specific nested polymerase chain reaction. Results: The most frequent genotype detected was genotype 4 (52.9%) followed by 3a (17.1%), 1b (12.9%) and 1a (1.4%), while mixed genotypes (4 with either 3a or 1b) were detected in 7.1%. Conclusion: The predominance of genotype 4 is similar to other studies from surrounding Eastern Mediterranean Arab countries and to the only earlier study from central Iraq, however the significant high proportion of 3a and scarcity of 1a, are in contrast to the latter study and may be explainable by the differing population interactions in this part of Iraq. This study complements previous studies from Eastern Mediterranean region and demonstrates relative heterogeneity of HCV genotype distribution within Iraq and should trigger further studies in other parts of the country.http://www.ajts.org/article.asp?issn=0973-6247;year=2014;volume=8;issue=1;spage=32;epage=34;aulast=OthmanGenotype 4genotypinghepatitis C virusIraq |
| spellingShingle | Adil A Othman Adil A Eissa Raji D Markous Bayram D Ahmed Nasir A. S Al-Allawi Hepatitis C virus genotypes among multiply transfused hemoglobinopathy patients from Northern Iraq Asian Journal of Transfusion Science Genotype 4 genotyping hepatitis C virus Iraq |
| title | Hepatitis C virus genotypes among multiply transfused hemoglobinopathy patients from Northern Iraq |
| title_full | Hepatitis C virus genotypes among multiply transfused hemoglobinopathy patients from Northern Iraq |
| title_fullStr | Hepatitis C virus genotypes among multiply transfused hemoglobinopathy patients from Northern Iraq |
| title_full_unstemmed | Hepatitis C virus genotypes among multiply transfused hemoglobinopathy patients from Northern Iraq |
| title_short | Hepatitis C virus genotypes among multiply transfused hemoglobinopathy patients from Northern Iraq |
| title_sort | hepatitis c virus genotypes among multiply transfused hemoglobinopathy patients from northern iraq |
| topic | Genotype 4 genotyping hepatitis C virus Iraq |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2014;volume=8;issue=1;spage=32;epage=34;aulast=Othman |
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