Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy
Abstract Cancer has been one of the major threats to the lives of human beings for centuries. Traditional therapy is more or less faced with certain defects, such as poor targeting, easy degradation, high side effects, etc. Therefore, in order to improve the treatment efficiency of drugs, an intelli...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-03-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202003033 |
| _version_ | 1818444045774487552 |
|---|---|
| author | Wenxin Liu Alideertu Dong Bing Wang Han Zhang |
| author_facet | Wenxin Liu Alideertu Dong Bing Wang Han Zhang |
| author_sort | Wenxin Liu |
| collection | DOAJ |
| description | Abstract Cancer has been one of the major threats to the lives of human beings for centuries. Traditional therapy is more or less faced with certain defects, such as poor targeting, easy degradation, high side effects, etc. Therefore, in order to improve the treatment efficiency of drugs, an intelligent drug delivery system (DDS) is considered as a promising solution strategy. Due to their special structure and large specific surface area, 2D materials are considered to be a good platform for drug delivery. Black phosphorus (BP), as a new star of the 2D family, is recommended to have the potential to construct DDS by virtue of its outstanding photothermal therapy (PTT), photodynamic therapy (PDT), and biodegradable properties. This tutorial review is intended to provide an introduction of the current advances in BP‐based DDSs for cancer therapy, which covers topics from its construction, classified by the types of platforms, to the stimuli‐responsive controlled drug release. Moreover, their cancer therapy applications including mono‐, bi‐, and multi‐modal synergistic cancer therapy as well as the research of biocompatibility are also discussed. Finally, the current status and future prospects of BP‐based DDSs for cancer therapy are summarized. |
| first_indexed | 2024-12-14T19:09:42Z |
| format | Article |
| id | doaj.art-035ad408ffab4d7fbe50535ddf481386 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-14T19:09:42Z |
| publishDate | 2021-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-035ad408ffab4d7fbe50535ddf4813862022-12-21T22:50:44ZengWileyAdvanced Science2198-38442021-03-0185n/an/a10.1002/advs.202003033Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer TherapyWenxin Liu0Alideertu Dong1Bing Wang2Han Zhang3College of Chemistry and Chemical Engineering Inner Mongolia University Hohhot 010021 P. R. ChinaCollege of Chemistry and Chemical Engineering Inner Mongolia University Hohhot 010021 P. R. ChinaShenzhen Engineering Laboratory of Phosphorene and Optoelectronics Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen 518060 P. R. ChinaShenzhen Engineering Laboratory of Phosphorene and Optoelectronics Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen 518060 P. R. ChinaAbstract Cancer has been one of the major threats to the lives of human beings for centuries. Traditional therapy is more or less faced with certain defects, such as poor targeting, easy degradation, high side effects, etc. Therefore, in order to improve the treatment efficiency of drugs, an intelligent drug delivery system (DDS) is considered as a promising solution strategy. Due to their special structure and large specific surface area, 2D materials are considered to be a good platform for drug delivery. Black phosphorus (BP), as a new star of the 2D family, is recommended to have the potential to construct DDS by virtue of its outstanding photothermal therapy (PTT), photodynamic therapy (PDT), and biodegradable properties. This tutorial review is intended to provide an introduction of the current advances in BP‐based DDSs for cancer therapy, which covers topics from its construction, classified by the types of platforms, to the stimuli‐responsive controlled drug release. Moreover, their cancer therapy applications including mono‐, bi‐, and multi‐modal synergistic cancer therapy as well as the research of biocompatibility are also discussed. Finally, the current status and future prospects of BP‐based DDSs for cancer therapy are summarized.https://doi.org/10.1002/advs.202003033biocompatibilityblack phosphoruscancer therapydrug deliverystimuli‐responsive release |
| spellingShingle | Wenxin Liu Alideertu Dong Bing Wang Han Zhang Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy Advanced Science biocompatibility black phosphorus cancer therapy drug delivery stimuli‐responsive release |
| title | Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy |
| title_full | Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy |
| title_fullStr | Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy |
| title_full_unstemmed | Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy |
| title_short | Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy |
| title_sort | current advances in black phosphorus based drug delivery systems for cancer therapy |
| topic | biocompatibility black phosphorus cancer therapy drug delivery stimuli‐responsive release |
| url | https://doi.org/10.1002/advs.202003033 |
| work_keys_str_mv | AT wenxinliu currentadvancesinblackphosphorusbaseddrugdeliverysystemsforcancertherapy AT alideertudong currentadvancesinblackphosphorusbaseddrugdeliverysystemsforcancertherapy AT bingwang currentadvancesinblackphosphorusbaseddrugdeliverysystemsforcancertherapy AT hanzhang currentadvancesinblackphosphorusbaseddrugdeliverysystemsforcancertherapy |