Establishment of the serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy in the city of São Paulo, Brazil
Several strategies aim at characterizing the AIDS epidemic in different parts of the world. Among these, the identification of recent HIV-1 infections using the recently described serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy was employed...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600003&lng=en&tlng=en |
| _version_ | 1819008571490172928 |
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| author | Esper Georges Kallas Katia Cristina Bassichetto Solange Maria Oliveira Ieda Goldenberg Reginaldo Bortoloto Diva Maria Faleiros C. Moreno Cecilia Kanashiro Mariana Mellilo Sauer Chaves Maria Cecilia A. Sucupira Aparecido Diniz Fabio C. Mesquita |
| author_facet | Esper Georges Kallas Katia Cristina Bassichetto Solange Maria Oliveira Ieda Goldenberg Reginaldo Bortoloto Diva Maria Faleiros C. Moreno Cecilia Kanashiro Mariana Mellilo Sauer Chaves Maria Cecilia A. Sucupira Aparecido Diniz Fabio C. Mesquita |
| author_sort | Esper Georges Kallas |
| collection | DOAJ |
| description | Several strategies aim at characterizing the AIDS epidemic in different parts of the world. Among these, the identification of recent HIV-1 infections using the recently described serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy was employed in four testing sites of the City of São Paulo Public Health Department (CSPPHD). Those identified as recently infected were invited to participate in a prospective clinical and laboratory evaluation study. We describe the establishment of the patient identification network and the success in enrolling the participants, as well as their clinical and laboratory characteristics. From May to December 2002, 6,443 persons were tested for HIV in the four participating sites, of whom 384 (5.96%) tested HIV-1 positive; 43 (11.2%) of them were identified as recently infected. Twenty-two were successfully enrolled in the follow-up study, but three of them did not meet clinical and/or laboratory criteria for recent HIV-1 infection. After these exclusions, the laboratory findings revealed a median CD4+ T lymphocyte count of 585 cells/muL (inter-quartile range 25-75% [IQR], 372-754), a CD8+ T lymphocyte count of 886 cells/muL (IQR, 553-1098), a viral load of 11,000 HIV-RNA copies/mL (IQR, 3,650-78,150), log10 of 4.04 (IQR 3.56-4.88). The identification of recent HIV infections is an extremely valuable way to evaluate the spread of the virus in a given population, especially when cohort studies, considered the gold standard method to evaluate incidence, are not available. This work demonstrated that establishing a network to identify such patients is a feasible task, even considering the difficulties in a large, resource-limited country or city. |
| first_indexed | 2024-12-21T00:42:35Z |
| format | Article |
| id | doaj.art-035f6d46f37d410fa0d23d2e3f188952 |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-21T00:42:35Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-035f6d46f37d410fa0d23d2e3f1889522022-12-21T19:21:37ZengElsevierBrazilian Journal of Infectious Diseases1678-43918639940610.1590/S1413-86702004000600003S1413-86702004000600003Establishment of the serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy in the city of São Paulo, BrazilEsper Georges Kallas0Katia Cristina Bassichetto1Solange Maria Oliveira2Ieda Goldenberg3Reginaldo Bortoloto4Diva Maria Faleiros C. Moreno5Cecilia Kanashiro6Mariana Mellilo Sauer Chaves7Maria Cecilia A. Sucupira8Aparecido Diniz9Fabio C. Mesquita10Universidade Federal de São PauloPublic Health Department of São PauloHenfil Counseling Testing CenterSpecialized Attending Service in STD/Aids Campos ElíseosPrevention and Attendance Center in STD/Aids LapaPirituba Counseling Testing CenterLapa City Central LaboratoryUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloPublic Health Department of São PauloSeveral strategies aim at characterizing the AIDS epidemic in different parts of the world. Among these, the identification of recent HIV-1 infections using the recently described serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy was employed in four testing sites of the City of São Paulo Public Health Department (CSPPHD). Those identified as recently infected were invited to participate in a prospective clinical and laboratory evaluation study. We describe the establishment of the patient identification network and the success in enrolling the participants, as well as their clinical and laboratory characteristics. From May to December 2002, 6,443 persons were tested for HIV in the four participating sites, of whom 384 (5.96%) tested HIV-1 positive; 43 (11.2%) of them were identified as recently infected. Twenty-two were successfully enrolled in the follow-up study, but three of them did not meet clinical and/or laboratory criteria for recent HIV-1 infection. After these exclusions, the laboratory findings revealed a median CD4+ T lymphocyte count of 585 cells/muL (inter-quartile range 25-75% [IQR], 372-754), a CD8+ T lymphocyte count of 886 cells/muL (IQR, 553-1098), a viral load of 11,000 HIV-RNA copies/mL (IQR, 3,650-78,150), log10 of 4.04 (IQR 3.56-4.88). The identification of recent HIV infections is an extremely valuable way to evaluate the spread of the virus in a given population, especially when cohort studies, considered the gold standard method to evaluate incidence, are not available. This work demonstrated that establishing a network to identify such patients is a feasible task, even considering the difficulties in a large, resource-limited country or city.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600003&lng=en&tlng=enHIVrecent infectionnetworkSão Paulo |
| spellingShingle | Esper Georges Kallas Katia Cristina Bassichetto Solange Maria Oliveira Ieda Goldenberg Reginaldo Bortoloto Diva Maria Faleiros C. Moreno Cecilia Kanashiro Mariana Mellilo Sauer Chaves Maria Cecilia A. Sucupira Aparecido Diniz Fabio C. Mesquita Establishment of the serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy in the city of São Paulo, Brazil Brazilian Journal of Infectious Diseases HIV recent infection network São Paulo |
| title | Establishment of the serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy in the city of São Paulo, Brazil |
| title_full | Establishment of the serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy in the city of São Paulo, Brazil |
| title_fullStr | Establishment of the serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy in the city of São Paulo, Brazil |
| title_full_unstemmed | Establishment of the serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy in the city of São Paulo, Brazil |
| title_short | Establishment of the serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy in the city of São Paulo, Brazil |
| title_sort | establishment of the serologic testing algorithm for recent human immunodeficiency virus hiv seroconversion starhs strategy in the city of sao paulo brazil |
| topic | HIV recent infection network São Paulo |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600003&lng=en&tlng=en |
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