Investigating Ovulation Induction Outcomes in Patients with Decreased Ovarian Reserve Treated with Double Stimulation during The Follicular and Luteal Phases Compared to The Conventional Antagonist Cycle: A Randomized Clinical Trial
Background: It is difficult to obtain healthy oocytes in poor ovarian responders with conventional treatment methods.Thus, the need to investigate new methods is essential. This study aims to investigate ovulation induction outcomesin patients with decreased ovarian reserve (DOR) in two groups treat...
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| Format: | Article |
| Language: | English |
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Royan Institute (ACECR), Tehran
2024-04-01
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| Series: | International Journal of Fertility and Sterility |
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| Online Access: | https://www.ijfs.ir/article_709662_0cf983f40cbf0887cc5c3a18fb2ac31b.pdf |
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| author | Fatemeh Ghahghayi Abolfazl Payandeh Aida Najafian Marzieh Ghasemi Ayob Jabari Jabari |
| author_facet | Fatemeh Ghahghayi Abolfazl Payandeh Aida Najafian Marzieh Ghasemi Ayob Jabari Jabari |
| author_sort | Fatemeh Ghahghayi |
| collection | DOAJ |
| description | Background: It is difficult to obtain healthy oocytes in poor ovarian responders with conventional treatment methods.Thus, the need to investigate new methods is essential. This study aims to investigate ovulation induction outcomesin patients with decreased ovarian reserve (DOR) in two groups treated with double stimulation (DuoStim) during thefollicular and luteal phases in comparison with the antagonist cycle.Materials and Methods: This was a randomised clinical trial that enrolled the patients with reduced ovarian reserve. Thepatients referred for in vitro fertilisation (IVF) at Molud Infertility Clinic, Ali Ebn Abitalib (AS) Hospital, Zahedan, Iranfrom 2020 to 2021. Participants were randomly divided into two groups, those who underwent treatment with DuoStimduring the follicular and luteal phase (case group) and those who received the conventional antagonist cycle (control group).Results: The mean number of metaphase II (MII) eggs was 7.7 ± 3.1 in the case group and 6.1 ± 3.9 in the controlgroup (P=0.063). The mean total number of retrieved eggs in the case group was 9.2 ± 3.7 and in the control group, itwas 6.9 ± 4.4 (P=0.023). The mean number of embryos obtained in the case group was 6.5 ± 3.9; in the control group,it was 4.7 ± 2.8 (P=0.016).Conclusion: The DuoStim method can effectively play a role in increasing the total number of retrieved eggs and embryos(registration number: IRCT20120817010617N8). |
| first_indexed | 2024-03-07T23:54:33Z |
| format | Article |
| id | doaj.art-035fed28bd814bb3bbac6d094cbb425b |
| institution | Directory Open Access Journal |
| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-03-07T23:54:33Z |
| publishDate | 2024-04-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-035fed28bd814bb3bbac6d094cbb425b2024-02-18T08:39:20ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782024-04-0118214014510.22074/ijfs.2023.1978181.1405709662Investigating Ovulation Induction Outcomes in Patients with Decreased Ovarian Reserve Treated with Double Stimulation during The Follicular and Luteal Phases Compared to The Conventional Antagonist Cycle: A Randomized Clinical TrialFatemeh Ghahghayi0Abolfazl Payandeh1Aida Najafian2Marzieh Ghasemi3Ayob Jabari Jabari4Department of Obstetrics and Gynaecology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, IranDepartment of Biostatistics and Epidemiology, Infectious Diseases and Tropical Medicine Research Centre, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, IranDepartment of Obstetrics, Gynaecology and Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Obstetrics and Gynaecology, Molud Infertility Centre, Zahedan University of Medical Sciences, Zahedan, IranDepartment of Obstetrics and Gynaecology, Molud Infertility Centre, Zahedan University of Medical Sciences, Zahedan, IranBackground: It is difficult to obtain healthy oocytes in poor ovarian responders with conventional treatment methods.Thus, the need to investigate new methods is essential. This study aims to investigate ovulation induction outcomesin patients with decreased ovarian reserve (DOR) in two groups treated with double stimulation (DuoStim) during thefollicular and luteal phases in comparison with the antagonist cycle.Materials and Methods: This was a randomised clinical trial that enrolled the patients with reduced ovarian reserve. Thepatients referred for in vitro fertilisation (IVF) at Molud Infertility Clinic, Ali Ebn Abitalib (AS) Hospital, Zahedan, Iranfrom 2020 to 2021. Participants were randomly divided into two groups, those who underwent treatment with DuoStimduring the follicular and luteal phase (case group) and those who received the conventional antagonist cycle (control group).Results: The mean number of metaphase II (MII) eggs was 7.7 ± 3.1 in the case group and 6.1 ± 3.9 in the controlgroup (P=0.063). The mean total number of retrieved eggs in the case group was 9.2 ± 3.7 and in the control group, itwas 6.9 ± 4.4 (P=0.023). The mean number of embryos obtained in the case group was 6.5 ± 3.9; in the control group,it was 4.7 ± 2.8 (P=0.016).Conclusion: The DuoStim method can effectively play a role in increasing the total number of retrieved eggs and embryos(registration number: IRCT20120817010617N8).https://www.ijfs.ir/article_709662_0cf983f40cbf0887cc5c3a18fb2ac31b.pdfantagonistdouble stimulationfollicularin vitro fertilisationluteal |
| spellingShingle | Fatemeh Ghahghayi Abolfazl Payandeh Aida Najafian Marzieh Ghasemi Ayob Jabari Jabari Investigating Ovulation Induction Outcomes in Patients with Decreased Ovarian Reserve Treated with Double Stimulation during The Follicular and Luteal Phases Compared to The Conventional Antagonist Cycle: A Randomized Clinical Trial International Journal of Fertility and Sterility antagonist double stimulation follicular in vitro fertilisation luteal |
| title | Investigating Ovulation Induction Outcomes in Patients with Decreased Ovarian Reserve Treated with Double Stimulation during The Follicular and Luteal Phases Compared to The Conventional Antagonist Cycle: A Randomized Clinical Trial |
| title_full | Investigating Ovulation Induction Outcomes in Patients with Decreased Ovarian Reserve Treated with Double Stimulation during The Follicular and Luteal Phases Compared to The Conventional Antagonist Cycle: A Randomized Clinical Trial |
| title_fullStr | Investigating Ovulation Induction Outcomes in Patients with Decreased Ovarian Reserve Treated with Double Stimulation during The Follicular and Luteal Phases Compared to The Conventional Antagonist Cycle: A Randomized Clinical Trial |
| title_full_unstemmed | Investigating Ovulation Induction Outcomes in Patients with Decreased Ovarian Reserve Treated with Double Stimulation during The Follicular and Luteal Phases Compared to The Conventional Antagonist Cycle: A Randomized Clinical Trial |
| title_short | Investigating Ovulation Induction Outcomes in Patients with Decreased Ovarian Reserve Treated with Double Stimulation during The Follicular and Luteal Phases Compared to The Conventional Antagonist Cycle: A Randomized Clinical Trial |
| title_sort | investigating ovulation induction outcomes in patients with decreased ovarian reserve treated with double stimulation during the follicular and luteal phases compared to the conventional antagonist cycle a randomized clinical trial |
| topic | antagonist double stimulation follicular in vitro fertilisation luteal |
| url | https://www.ijfs.ir/article_709662_0cf983f40cbf0887cc5c3a18fb2ac31b.pdf |
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