Case Report: Neuroblastoma-Like Schwannoma in a Domestic Short-Haired Cat
An axillary mass was detected in a 6-year-old, neutered, male, domestic short-haired cat during a wellness exam. Gross examination following surgical removal revealed a discrete, deep subcutaneous, discoid mass that was between 0.5- and 0.7-cm-in-diameter and diffusely firm and white. Histologically...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.905302/full |
| _version_ | 1828729773052919808 |
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| author | Vivian S. Chen Andrew W. Bollen Paola Marco-Salazar Robert J. Higgins Sílvia Sisó Sílvia Sisó |
| author_facet | Vivian S. Chen Andrew W. Bollen Paola Marco-Salazar Robert J. Higgins Sílvia Sisó Sílvia Sisó |
| author_sort | Vivian S. Chen |
| collection | DOAJ |
| description | An axillary mass was detected in a 6-year-old, neutered, male, domestic short-haired cat during a wellness exam. Gross examination following surgical removal revealed a discrete, deep subcutaneous, discoid mass that was between 0.5- and 0.7-cm-in-diameter and diffusely firm and white. Histologically, the mass was well-demarcated, partially encapsulated, and expanded the panniculus carnosus. It was composed of tightly packed, giant rosettes of radially arranged fusiform cells stacked in one to 10 layers with peripherally palisading nuclei and with centrally oriented, fibrillary, cytoplasmic processes, and collagenous fibers. Laminin immunoreactivity and ultrastructural examination highlighted a continuous basal lamina outside the plasma membrane of each neoplastic cell. Neoplastic cells were immunoreactive for GFAP, S100, periaxin, and Sox-10 and were immunonegative for synaptophysin, smooth muscle actin, and pancytokeratin. Collective findings were consistent with a diagnosis of neuroblastoma-like schwannoma. This is the first veterinary report of this rare variant of benign schwannoma. |
| first_indexed | 2024-04-12T14:37:38Z |
| format | Article |
| id | doaj.art-03601b812e5c4bc58582120eade81718 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-12T14:37:38Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-03601b812e5c4bc58582120eade817182022-12-22T03:29:00ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-06-01910.3389/fvets.2022.905302905302Case Report: Neuroblastoma-Like Schwannoma in a Domestic Short-Haired CatVivian S. Chen0Andrew W. Bollen1Paola Marco-Salazar2Robert J. Higgins3Sílvia Sisó4Sílvia Sisó5Charles River Laboratories, Inc., Durham, NC, United StatesNeuropathology Division, Department of Pathology, School of Medicine, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Medicine and Animal Surgery, School of Veterinary Medicine, Autonomous University of Barcelona (UAB), Bellaterra, SpainDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United StatesDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United StatesTranslational Imaging and Pathology, Codiak BioSciences, Cambridge, MA, United StatesAn axillary mass was detected in a 6-year-old, neutered, male, domestic short-haired cat during a wellness exam. Gross examination following surgical removal revealed a discrete, deep subcutaneous, discoid mass that was between 0.5- and 0.7-cm-in-diameter and diffusely firm and white. Histologically, the mass was well-demarcated, partially encapsulated, and expanded the panniculus carnosus. It was composed of tightly packed, giant rosettes of radially arranged fusiform cells stacked in one to 10 layers with peripherally palisading nuclei and with centrally oriented, fibrillary, cytoplasmic processes, and collagenous fibers. Laminin immunoreactivity and ultrastructural examination highlighted a continuous basal lamina outside the plasma membrane of each neoplastic cell. Neoplastic cells were immunoreactive for GFAP, S100, periaxin, and Sox-10 and were immunonegative for synaptophysin, smooth muscle actin, and pancytokeratin. Collective findings were consistent with a diagnosis of neuroblastoma-like schwannoma. This is the first veterinary report of this rare variant of benign schwannoma.https://www.frontiersin.org/articles/10.3389/fvets.2022.905302/fullschwannomaneurilemomaperipheral nerve sheath tumorneuroblastomacat |
| spellingShingle | Vivian S. Chen Andrew W. Bollen Paola Marco-Salazar Robert J. Higgins Sílvia Sisó Sílvia Sisó Case Report: Neuroblastoma-Like Schwannoma in a Domestic Short-Haired Cat Frontiers in Veterinary Science schwannoma neurilemoma peripheral nerve sheath tumor neuroblastoma cat |
| title | Case Report: Neuroblastoma-Like Schwannoma in a Domestic Short-Haired Cat |
| title_full | Case Report: Neuroblastoma-Like Schwannoma in a Domestic Short-Haired Cat |
| title_fullStr | Case Report: Neuroblastoma-Like Schwannoma in a Domestic Short-Haired Cat |
| title_full_unstemmed | Case Report: Neuroblastoma-Like Schwannoma in a Domestic Short-Haired Cat |
| title_short | Case Report: Neuroblastoma-Like Schwannoma in a Domestic Short-Haired Cat |
| title_sort | case report neuroblastoma like schwannoma in a domestic short haired cat |
| topic | schwannoma neurilemoma peripheral nerve sheath tumor neuroblastoma cat |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.905302/full |
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