Nuclear Wiskott–Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells

Nuclear Wiskott–Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells

Abstract Background The Wiskott–Aldrich syndrome protein (WASp) family of actin-nucleating factors are present in the cytoplasm and in the nucleus. The role of nuclear WASp for T cell development remains incompletely defined. Methods We performed WASp chromatin immunoprecipitation and deep sequencin...

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Bibliographic Details
Main Authors: Nikolai V. Kuznetsov, Bader Almuzzaini, Joanna S. Kritikou, Marisa A. P. Baptista, Mariana M. S. Oliveira, Marton Keszei, Scott B. Snapper, Piergiorgio Percipalle, Lisa S. Westerberg
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Genome Medicine
Subjects:
WASp
T cells
ChIP-seq
Wiskott–Aldrich syndrome
TCF1
TCF12
Online Access:http://link.springer.com/article/10.1186/s13073-017-0481-6

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