Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitis
<p>Abstract</p> <p>Background</p> <p>Severe hypertriglyceridaemia due to chylomicronemia may trigger an acute pancreatitis. However, the basic underlying mechanism is usually not well understood. We decided to analyze some proteins involved in the catabolism of triglyce...
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| Format: | Article |
| Language: | English |
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BMC
2009-06-01
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| Series: | BMC Gastroenterology |
| Online Access: | http://www.biomedcentral.com/1471-230X/9/46 |
| _version_ | 1818382488361238528 |
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| author | García-Arias Carlota Font-Ugalde Pilar Rioja José Ariza María Olivecrona Gunilla Valdivielso Pedro Coca-Prieto Inmaculada González-Santos Pedro |
| author_facet | García-Arias Carlota Font-Ugalde Pilar Rioja José Ariza María Olivecrona Gunilla Valdivielso Pedro Coca-Prieto Inmaculada González-Santos Pedro |
| author_sort | García-Arias Carlota |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Severe hypertriglyceridaemia due to chylomicronemia may trigger an acute pancreatitis. However, the basic underlying mechanism is usually not well understood. We decided to analyze some proteins involved in the catabolism of triglyceride-rich lipoproteins in patients with severe hypertriglyceridaemia.</p> <p>Methods</p> <p>Twenty-four survivors of acute hypertriglyceridaemic pancreatitis (cases) and 31 patients with severe hypertriglyceridaemia (controls) were included. Clinical and anthropometrical data, chylomicronaemia, lipoprotein profile, postheparin lipoprotein lipase mass and activity, hepatic lipase activity, apolipoprotein C II and CIII mass, apo E and A5 polymorphisms were assessed.</p> <p>Results</p> <p>Only five cases were found to have LPL mass and activity deficiency, all of them thin and having the first episode in childhood. No cases had apolipoprotein CII deficiency. No significant differences were found between the non-deficient LPL cases and the controls in terms of obesity, diabetes, alcohol consumption, drug therapy, gender distribution, evidence of fasting chylomicronaemia, lipid levels, LPL activity and mass, hepatic lipase activity, CII and CIII mass or apo E polymorphisms. However, the SNP S19W of apo A5 tended to be more prevalent in cases than controls (40% vs. 23%, NS).</p> <p>Conclusion</p> <p>Primary defects in LPL and C-II are rare in survivors of acute hypertriglyceridaemic pancreatitis; lipase activity measurements should be restricted to those having their first episode during chilhood.</p> |
| first_indexed | 2024-12-14T02:51:16Z |
| format | Article |
| id | doaj.art-03658b772fcd43b2b0eb07b1fb569426 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-14T02:51:16Z |
| publishDate | 2009-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-03658b772fcd43b2b0eb07b1fb5694262022-12-21T23:19:45ZengBMCBMC Gastroenterology1471-230X2009-06-01914610.1186/1471-230X-9-46Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitisGarcía-Arias CarlotaFont-Ugalde PilarRioja JoséAriza MaríaOlivecrona GunillaValdivielso PedroCoca-Prieto InmaculadaGonzález-Santos Pedro<p>Abstract</p> <p>Background</p> <p>Severe hypertriglyceridaemia due to chylomicronemia may trigger an acute pancreatitis. However, the basic underlying mechanism is usually not well understood. We decided to analyze some proteins involved in the catabolism of triglyceride-rich lipoproteins in patients with severe hypertriglyceridaemia.</p> <p>Methods</p> <p>Twenty-four survivors of acute hypertriglyceridaemic pancreatitis (cases) and 31 patients with severe hypertriglyceridaemia (controls) were included. Clinical and anthropometrical data, chylomicronaemia, lipoprotein profile, postheparin lipoprotein lipase mass and activity, hepatic lipase activity, apolipoprotein C II and CIII mass, apo E and A5 polymorphisms were assessed.</p> <p>Results</p> <p>Only five cases were found to have LPL mass and activity deficiency, all of them thin and having the first episode in childhood. No cases had apolipoprotein CII deficiency. No significant differences were found between the non-deficient LPL cases and the controls in terms of obesity, diabetes, alcohol consumption, drug therapy, gender distribution, evidence of fasting chylomicronaemia, lipid levels, LPL activity and mass, hepatic lipase activity, CII and CIII mass or apo E polymorphisms. However, the SNP S19W of apo A5 tended to be more prevalent in cases than controls (40% vs. 23%, NS).</p> <p>Conclusion</p> <p>Primary defects in LPL and C-II are rare in survivors of acute hypertriglyceridaemic pancreatitis; lipase activity measurements should be restricted to those having their first episode during chilhood.</p>http://www.biomedcentral.com/1471-230X/9/46 |
| spellingShingle | García-Arias Carlota Font-Ugalde Pilar Rioja José Ariza María Olivecrona Gunilla Valdivielso Pedro Coca-Prieto Inmaculada González-Santos Pedro Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitis BMC Gastroenterology |
| title | Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitis |
| title_full | Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitis |
| title_fullStr | Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitis |
| title_full_unstemmed | Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitis |
| title_short | Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitis |
| title_sort | lipoprotein lipase activity and mass apolipoprotein c ii mass and polymorphisms of apolipoproteins e and a5 in subjects with prior acute hypertriglyceridaemic pancreatitis |
| url | http://www.biomedcentral.com/1471-230X/9/46 |
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