Comparing methotrexate monotherapy with methotrexate plus leflunomide combination therapy in psoriatic arthritis: protocol of a randomized, placebo-controlled, double-blind clinical trial (COMPLETE-PsA)

Comparing methotrexate monotherapy with methotrexate plus leflunomide combination therapy in psoriatic arthritis: protocol of a randomized, placebo-controlled, double-blind clinical trial (COMPLETE-PsA)

Abstract Background Both methotrexate (MTX) and leflunomide (LEF) are registered and regularly prescribed as first-line treatments for the use in patients with psoriatic arthritis (PsA) and they are occasionally used in combination. However, evidence about their individual, and especially combined e...

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Bibliographic Details
Main Authors: Michelle L. M. Mulder, Johanna E. Vriezekolk, Nathan den Broeder, Elien A. M. Mahler, Philip S. Helliwell, Frank H. J. van den Hoogen, Alfons A. den Broeder, Mark H. Wenink
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Trials
Subjects:
Psoriatic arthritis
Methotrexate
Leflunomide
Conventional disease-modifying antirheumatic drug (cDMARD)
Combination therapy
Online Access:https://doi.org/10.1186/s13063-020-4097-6

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