Differential effects of sugar and fat on adipose tissue inflammation
Summary: Obese individuals experience low grade inflammation initiated within their adipose tissue. However, the early events that lead to the release of these inflammatory factors from adipose tissue are poorly characterized. To separate glucose effects from lipid effects on adipose tissue, we used...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223012403 |
| _version_ | 1797774522912342016 |
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| author | Tracey Avequin Kin H. Lau Althea N. Waldhart Hannah Guak Holly Dykstra Connie Krawczyk Ning Wu |
| author_facet | Tracey Avequin Kin H. Lau Althea N. Waldhart Hannah Guak Holly Dykstra Connie Krawczyk Ning Wu |
| author_sort | Tracey Avequin |
| collection | DOAJ |
| description | Summary: Obese individuals experience low grade inflammation initiated within their adipose tissue. However, the early events that lead to the release of these inflammatory factors from adipose tissue are poorly characterized. To separate glucose effects from lipid effects on adipose tissue, we used an adipose-specific TXNIP knockout model where excess basal glucose influx into adipocytes led to modest increase in adiposity without using high fat diet. We found an uncoupling of two events that are generally presumed to be coregulated: (1) an increase of adipose tissue macrophage (ATM) number; and (2) pro-inflammatory activation of ATMs. These two events are associated with different triggering signals: elevated free fatty acids output and extracellular matrix remodeling with increased ATM number, whereas decreased adiponectin level with activated ATM. This separation reflects non-overlapping pathways regulated by glucose and lipids in adipocytes, and neither group alone is sufficient to elicit the full inflammatory response in adipose tissue. |
| first_indexed | 2024-03-12T22:21:21Z |
| format | Article |
| id | doaj.art-0368fc9a315e495197f489861e05bdad |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T22:21:21Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-0368fc9a315e495197f489861e05bdad2023-07-23T04:55:46ZengElsevieriScience2589-00422023-07-01267107163Differential effects of sugar and fat on adipose tissue inflammationTracey Avequin0Kin H. Lau1Althea N. Waldhart2Hannah Guak3Holly Dykstra4Connie Krawczyk5Ning Wu6Van Andel Institute, Grand Rapids, MI 49503, USAVan Andel Institute, Grand Rapids, MI 49503, USAVan Andel Institute, Grand Rapids, MI 49503, USADepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USAVan Andel Institute, Grand Rapids, MI 49503, USAVan Andel Institute, Grand Rapids, MI 49503, USAVan Andel Institute, Grand Rapids, MI 49503, USA; Corresponding authorSummary: Obese individuals experience low grade inflammation initiated within their adipose tissue. However, the early events that lead to the release of these inflammatory factors from adipose tissue are poorly characterized. To separate glucose effects from lipid effects on adipose tissue, we used an adipose-specific TXNIP knockout model where excess basal glucose influx into adipocytes led to modest increase in adiposity without using high fat diet. We found an uncoupling of two events that are generally presumed to be coregulated: (1) an increase of adipose tissue macrophage (ATM) number; and (2) pro-inflammatory activation of ATMs. These two events are associated with different triggering signals: elevated free fatty acids output and extracellular matrix remodeling with increased ATM number, whereas decreased adiponectin level with activated ATM. This separation reflects non-overlapping pathways regulated by glucose and lipids in adipocytes, and neither group alone is sufficient to elicit the full inflammatory response in adipose tissue.http://www.sciencedirect.com/science/article/pii/S2589004223012403Cell biologyEndocrinologyImmunology |
| spellingShingle | Tracey Avequin Kin H. Lau Althea N. Waldhart Hannah Guak Holly Dykstra Connie Krawczyk Ning Wu Differential effects of sugar and fat on adipose tissue inflammation iScience Cell biology Endocrinology Immunology |
| title | Differential effects of sugar and fat on adipose tissue inflammation |
| title_full | Differential effects of sugar and fat on adipose tissue inflammation |
| title_fullStr | Differential effects of sugar and fat on adipose tissue inflammation |
| title_full_unstemmed | Differential effects of sugar and fat on adipose tissue inflammation |
| title_short | Differential effects of sugar and fat on adipose tissue inflammation |
| title_sort | differential effects of sugar and fat on adipose tissue inflammation |
| topic | Cell biology Endocrinology Immunology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223012403 |
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