Case report: Tall cell carcinoma with reversed polarity of the breast: an additional case and review of the literature
ObjectiveThe aim of this report was to comprehensively investigate the clinicopathological features, histological characteristics, and differential diagnosis of tall cell carcinoma with reversed polarity of the breast (TCCRP) to enhance the understanding of this tumour for precise therapeutic interv...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1302196/full |
| _version_ | 1797305204511604736 |
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| author | Zi Lei Ying-Xia Wang Zhi-Yuan Wang Cheng-gang Yang Guo-Qing Pan |
| author_facet | Zi Lei Ying-Xia Wang Zhi-Yuan Wang Cheng-gang Yang Guo-Qing Pan |
| author_sort | Zi Lei |
| collection | DOAJ |
| description | ObjectiveThe aim of this report was to comprehensively investigate the clinicopathological features, histological characteristics, and differential diagnosis of tall cell carcinoma with reversed polarity of the breast (TCCRP) to enhance the understanding of this tumour for precise therapeutic interventions.MethodsThe clinicopathological characteristics and differential diagnosis of a patient with TCCRP were retrospectively analysed, and a systematic literature review was extracted from relevant published studies on PubMed.ResultsAll patients included in the study were female, with a median age of 51 years. Microscopically, the tumour cells exhibited a solid papillary growth pattern with tall columnar morphology and reversed nuclear polarity. Immunohistochemistry revealed that the tumours were triple-negative breast cancer (negative for ER, PR, and HER-2), with a low Ki-67 proliferation index. Different degrees of expression were observed for CK7, Calretinin, and S-100 markers; however, CK5/6 showed high expression levels.ConclusionsTCCRP is an uncommon invasive carcinoma subtype found in the breast. Its histological morphology resembles that of tall cell subtype papillary thyroid carcinoma. Accurate diagnosis requires the integration of histomorphological assessment along with immunohistochemistry and molecular genetics analysis. |
| first_indexed | 2024-03-08T00:21:32Z |
| format | Article |
| id | doaj.art-03691e6bbdd841158d688b3dd7c9f2ab |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T00:21:32Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-03691e6bbdd841158d688b3dd7c9f2ab2024-02-16T04:59:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-02-011410.3389/fonc.2024.13021961302196Case report: Tall cell carcinoma with reversed polarity of the breast: an additional case and review of the literatureZi Lei0Ying-Xia Wang1Zhi-Yuan Wang2Cheng-gang Yang3Guo-Qing Pan4Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Pathology, Third Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaObjectiveThe aim of this report was to comprehensively investigate the clinicopathological features, histological characteristics, and differential diagnosis of tall cell carcinoma with reversed polarity of the breast (TCCRP) to enhance the understanding of this tumour for precise therapeutic interventions.MethodsThe clinicopathological characteristics and differential diagnosis of a patient with TCCRP were retrospectively analysed, and a systematic literature review was extracted from relevant published studies on PubMed.ResultsAll patients included in the study were female, with a median age of 51 years. Microscopically, the tumour cells exhibited a solid papillary growth pattern with tall columnar morphology and reversed nuclear polarity. Immunohistochemistry revealed that the tumours were triple-negative breast cancer (negative for ER, PR, and HER-2), with a low Ki-67 proliferation index. Different degrees of expression were observed for CK7, Calretinin, and S-100 markers; however, CK5/6 showed high expression levels.ConclusionsTCCRP is an uncommon invasive carcinoma subtype found in the breast. Its histological morphology resembles that of tall cell subtype papillary thyroid carcinoma. Accurate diagnosis requires the integration of histomorphological assessment along with immunohistochemistry and molecular genetics analysis.https://www.frontiersin.org/articles/10.3389/fonc.2024.1302196/fullbreast cancerTall cell carcinoma with reversed polarity of the breastclinicopathological featureshistological characteristicsdifferential diagnosis |
| spellingShingle | Zi Lei Ying-Xia Wang Zhi-Yuan Wang Cheng-gang Yang Guo-Qing Pan Case report: Tall cell carcinoma with reversed polarity of the breast: an additional case and review of the literature Frontiers in Oncology breast cancer Tall cell carcinoma with reversed polarity of the breast clinicopathological features histological characteristics differential diagnosis |
| title | Case report: Tall cell carcinoma with reversed polarity of the breast: an additional case and review of the literature |
| title_full | Case report: Tall cell carcinoma with reversed polarity of the breast: an additional case and review of the literature |
| title_fullStr | Case report: Tall cell carcinoma with reversed polarity of the breast: an additional case and review of the literature |
| title_full_unstemmed | Case report: Tall cell carcinoma with reversed polarity of the breast: an additional case and review of the literature |
| title_short | Case report: Tall cell carcinoma with reversed polarity of the breast: an additional case and review of the literature |
| title_sort | case report tall cell carcinoma with reversed polarity of the breast an additional case and review of the literature |
| topic | breast cancer Tall cell carcinoma with reversed polarity of the breast clinicopathological features histological characteristics differential diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1302196/full |
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