Association between Fibrinogen-to-Albumin Ratio and Prognosis of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis
Although the fibrinogen-to-albumin ratio (F/R ratio) has been used as an inflammation marker to predict clinical outcomes in patients with cardiovascular diseases, its association with the prognosis of patients with coronavirus disease 2019 (COVID-19) remains unclear. Electronic databases including...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/7/1678 |
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| author | Kuo-Chuan Hung Yen-Ta Huang Ying-Jen Chang Chia-Hung Yu Li-Kai Wang Chung-Yi Wu Ping-Hsin Liu Sheng-Fu Chiu Cheuk-Kwan Sun |
| author_facet | Kuo-Chuan Hung Yen-Ta Huang Ying-Jen Chang Chia-Hung Yu Li-Kai Wang Chung-Yi Wu Ping-Hsin Liu Sheng-Fu Chiu Cheuk-Kwan Sun |
| author_sort | Kuo-Chuan Hung |
| collection | DOAJ |
| description | Although the fibrinogen-to-albumin ratio (F/R ratio) has been used as an inflammation marker to predict clinical outcomes in patients with cardiovascular diseases, its association with the prognosis of patients with coronavirus disease 2019 (COVID-19) remains unclear. Electronic databases including EMBASE, MEDLINE, Google Scholar, and Cochrane Library were searched from inception to 20 June 2022. The associations of F/R ratio with poor prognosis (defined as the occurrence of mortality or severe disease) were investigated in patients with COVID-19. A total of 10 studies (seven from Turkey, two from China, one from Croatia) involving 3675 patients published between 2020 and 2022 were eligible for quantitative syntheses. Merged results revealed a higher F/R ratio in the poor prognosis group (standardized mean difference: 0.529, <i>p</i> < 0.001, I<sup>2</sup> = 84.8%, eight studies) than that in the good prognosis group. In addition, a high F/R ratio was associated with an increased risk of poor prognosis (odds ratio: 2.684, I<sup>2</sup> = 59.5%, five studies). Pooled analysis showed a sensitivity of 0.75, specificity of 0.66, and area under curve of 0.77 for poor prognosis prediction. In conclusion, this meta-analysis revealed a positive correlation between F/A ratio and poor prognostic outcomes of COVID-19. Because of the limited number of studies included, further investigations are warranted to support our findings. |
| first_indexed | 2024-03-09T03:31:06Z |
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| id | doaj.art-0369857b110749e6bd9e73b6d482fa61 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T03:31:06Z |
| publishDate | 2022-07-01 |
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| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-0369857b110749e6bd9e73b6d482fa612023-12-03T14:54:59ZengMDPI AGDiagnostics2075-44182022-07-01127167810.3390/diagnostics12071678Association between Fibrinogen-to-Albumin Ratio and Prognosis of Hospitalized Patients with COVID-19: A Systematic Review and Meta-AnalysisKuo-Chuan Hung0Yen-Ta Huang1Ying-Jen Chang2Chia-Hung Yu3Li-Kai Wang4Chung-Yi Wu5Ping-Hsin Liu6Sheng-Fu Chiu7Cheuk-Kwan Sun8Department of Anesthesiology, Chi Mei Medical Center, Tainan City 71004, TaiwanDepartment of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City 70101, TaiwanDepartment of Anesthesiology, Chi Mei Medical Center, Tainan City 71004, TaiwanDepartment of Anesthesiology, Chi Mei Medical Center, Tainan City 71004, TaiwanDepartment of Anesthesiology, Chi Mei Medical Center, Tainan City 71004, TaiwanDepartment of Anesthesiology, Chi Mei Medical Center, Tainan City 71004, TaiwanDepartment of Anesthesiology, E-Da Hospital, Kaohsiung City 82445, TaiwanDepartment of Oral and Maxillofacial Surgery, Chi Mei Medical Center, Liouying, Tainan City 73657, TaiwanDepartment of Emergency Medicine, E-Da Hospital, Kaohsiung City 82445, TaiwanAlthough the fibrinogen-to-albumin ratio (F/R ratio) has been used as an inflammation marker to predict clinical outcomes in patients with cardiovascular diseases, its association with the prognosis of patients with coronavirus disease 2019 (COVID-19) remains unclear. Electronic databases including EMBASE, MEDLINE, Google Scholar, and Cochrane Library were searched from inception to 20 June 2022. The associations of F/R ratio with poor prognosis (defined as the occurrence of mortality or severe disease) were investigated in patients with COVID-19. A total of 10 studies (seven from Turkey, two from China, one from Croatia) involving 3675 patients published between 2020 and 2022 were eligible for quantitative syntheses. Merged results revealed a higher F/R ratio in the poor prognosis group (standardized mean difference: 0.529, <i>p</i> < 0.001, I<sup>2</sup> = 84.8%, eight studies) than that in the good prognosis group. In addition, a high F/R ratio was associated with an increased risk of poor prognosis (odds ratio: 2.684, I<sup>2</sup> = 59.5%, five studies). Pooled analysis showed a sensitivity of 0.75, specificity of 0.66, and area under curve of 0.77 for poor prognosis prediction. In conclusion, this meta-analysis revealed a positive correlation between F/A ratio and poor prognostic outcomes of COVID-19. Because of the limited number of studies included, further investigations are warranted to support our findings.https://www.mdpi.com/2075-4418/12/7/1678fibrinogen-to-albumin ratiocoronavirus disease 2019mortalitydisease severitymeta-analysisprognosis |
| spellingShingle | Kuo-Chuan Hung Yen-Ta Huang Ying-Jen Chang Chia-Hung Yu Li-Kai Wang Chung-Yi Wu Ping-Hsin Liu Sheng-Fu Chiu Cheuk-Kwan Sun Association between Fibrinogen-to-Albumin Ratio and Prognosis of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis Diagnostics fibrinogen-to-albumin ratio coronavirus disease 2019 mortality disease severity meta-analysis prognosis |
| title | Association between Fibrinogen-to-Albumin Ratio and Prognosis of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis |
| title_full | Association between Fibrinogen-to-Albumin Ratio and Prognosis of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis |
| title_fullStr | Association between Fibrinogen-to-Albumin Ratio and Prognosis of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association between Fibrinogen-to-Albumin Ratio and Prognosis of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis |
| title_short | Association between Fibrinogen-to-Albumin Ratio and Prognosis of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis |
| title_sort | association between fibrinogen to albumin ratio and prognosis of hospitalized patients with covid 19 a systematic review and meta analysis |
| topic | fibrinogen-to-albumin ratio coronavirus disease 2019 mortality disease severity meta-analysis prognosis |
| url | https://www.mdpi.com/2075-4418/12/7/1678 |
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