Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis
Renal fibrosis progression is closely associated with aging, which ultimately leads to renal dysfunction. Salidroside (SAL) is considered to have broad anti-aging effects. However, the roles and mechanisms of SAL in aging-related renal fibrosis remain unclear. The study aimed to evaluate the protect...
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MDPI AG
2022-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/22/8039 |
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| author | Sixia Yang Tingting Pei Linshuang Wang Yi Zeng Wenxu Li Shihua Yan Wei Xiao Weidong Cheng |
| author_facet | Sixia Yang Tingting Pei Linshuang Wang Yi Zeng Wenxu Li Shihua Yan Wei Xiao Weidong Cheng |
| author_sort | Sixia Yang |
| collection | DOAJ |
| description | Renal fibrosis progression is closely associated with aging, which ultimately leads to renal dysfunction. Salidroside (SAL) is considered to have broad anti-aging effects. However, the roles and mechanisms of SAL in aging-related renal fibrosis remain unclear. The study aimed to evaluate the protective effects and mechanisms of SAL in SAMP8 mice. SAMP8 mice were administered with SAL and Ferrostatin-1 (Fer-1) for 12 weeks. Renal function, renal fibrosis, and ferroptosis in renal tissue were detected. The results showed that elevated blood urea nitrogen (BUN) and serum creatinine (SCr) levels significantly decreased, serum albumin (ALB) levels increased, and mesangial hyperplasia significantly reduced in the SAL group. SAL significantly reduced transforming growth factor-β (TGF-β) and α-smooth muscle actin (α-sma) levels in SAMP8 mice. SAL treatment significantly decreased lipid peroxidation in the kidneys, and regulated iron transport-related proteins and ferroptosis-related proteins. These results suggested that SAL delays renal aging and inhibits aging-related glomerular fibrosis by inhibiting ferroptosis in SAMP8 mice. |
| first_indexed | 2024-03-09T18:06:35Z |
| format | Article |
| id | doaj.art-036a1c73ad5846bc86a2767ae5055aa6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:06:35Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-036a1c73ad5846bc86a2767ae5055aa62023-11-24T09:25:25ZengMDPI AGMolecules1420-30492022-11-012722803910.3390/molecules27228039Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting FerroptosisSixia Yang0Tingting Pei1Linshuang Wang2Yi Zeng3Wenxu Li4Shihua Yan5Wei Xiao6Weidong Cheng7School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, ChinaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, ChinaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, ChinaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, ChinaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, ChinaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, ChinaRenal fibrosis progression is closely associated with aging, which ultimately leads to renal dysfunction. Salidroside (SAL) is considered to have broad anti-aging effects. However, the roles and mechanisms of SAL in aging-related renal fibrosis remain unclear. The study aimed to evaluate the protective effects and mechanisms of SAL in SAMP8 mice. SAMP8 mice were administered with SAL and Ferrostatin-1 (Fer-1) for 12 weeks. Renal function, renal fibrosis, and ferroptosis in renal tissue were detected. The results showed that elevated blood urea nitrogen (BUN) and serum creatinine (SCr) levels significantly decreased, serum albumin (ALB) levels increased, and mesangial hyperplasia significantly reduced in the SAL group. SAL significantly reduced transforming growth factor-β (TGF-β) and α-smooth muscle actin (α-sma) levels in SAMP8 mice. SAL treatment significantly decreased lipid peroxidation in the kidneys, and regulated iron transport-related proteins and ferroptosis-related proteins. These results suggested that SAL delays renal aging and inhibits aging-related glomerular fibrosis by inhibiting ferroptosis in SAMP8 mice.https://www.mdpi.com/1420-3049/27/22/8039renal fibrosisferroptosisagingsalidrosideiron transport |
| spellingShingle | Sixia Yang Tingting Pei Linshuang Wang Yi Zeng Wenxu Li Shihua Yan Wei Xiao Weidong Cheng Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis Molecules renal fibrosis ferroptosis aging salidroside iron transport |
| title | Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis |
| title_full | Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis |
| title_fullStr | Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis |
| title_full_unstemmed | Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis |
| title_short | Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis |
| title_sort | salidroside alleviates renal fibrosis in samp8 mice by inhibiting ferroptosis |
| topic | renal fibrosis ferroptosis aging salidroside iron transport |
| url | https://www.mdpi.com/1420-3049/27/22/8039 |
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