Immunoglobulin gene repertoire diversification and selection in the stomach – from gastritis to gastric lymphomas
Chronic gastritis is characterized by gastric mucosal inflammation due to autoimmune responses or infection, frequently with Helicobacter pylori. Gastritis with H. pylori background can cause gastric mucosa-associated lymphoid tissue lymphoma (MALT-L), which sometimes further transforms into diffuse...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00264/full |
| _version_ | 1819263162855194624 |
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| author | Miri eMichaeli Hilla eTabibian-Keissar Ginette eSchiby Gitit eShahaf Yishai ePickman Lena eHazanov Kinneret eRosenblatt Deborah K Dunn-Walters Iris eBarshack Iris eBarshack Ramit eMehr |
| author_facet | Miri eMichaeli Hilla eTabibian-Keissar Ginette eSchiby Gitit eShahaf Yishai ePickman Lena eHazanov Kinneret eRosenblatt Deborah K Dunn-Walters Iris eBarshack Iris eBarshack Ramit eMehr |
| author_sort | Miri eMichaeli |
| collection | DOAJ |
| description | Chronic gastritis is characterized by gastric mucosal inflammation due to autoimmune responses or infection, frequently with Helicobacter pylori. Gastritis with H. pylori background can cause gastric mucosa-associated lymphoid tissue lymphoma (MALT-L), which sometimes further transforms into diffuse large B cell lymphoma (DLBCL). However, gastric DLBCL can also be initiated de novo. The mechanisms underlying transformation into DLBCL are not completely understood. <br/>We analyzed immunoglobulin repertoires and clonal trees to investigate whether and how immunoglobulin gene repertoires, clonal diversification and selection in gastritis, gastric MALT-L and DLBCL differ from each other and from normal responses. The two gastritis types (positive or negative for H. pylori) had similarly diverse repertoires. MALT-L dominant clones presented higher diversification and longer mutational histories compared with all other conditions. DLBCL dominant clones displayed lower clonal diversification, suggesting the transforming events are triggered by similar responses in different patients. These results are surprising, as we expected to find similarities between the dominant clones of gastritis and MALT-L and between those of MALT-L and DLBCL. |
| first_indexed | 2024-12-23T20:09:13Z |
| format | Article |
| id | doaj.art-036a94bbcb224e8985b9a6c0475646d1 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T20:09:13Z |
| publishDate | 2014-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-036a94bbcb224e8985b9a6c0475646d12022-12-21T17:32:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-06-01510.3389/fimmu.2014.0026477347Immunoglobulin gene repertoire diversification and selection in the stomach – from gastritis to gastric lymphomasMiri eMichaeli0Hilla eTabibian-Keissar1Ginette eSchiby2Gitit eShahaf3Yishai ePickman4Lena eHazanov5Kinneret eRosenblatt6Deborah K Dunn-Walters7Iris eBarshack8Iris eBarshack9Ramit eMehr10Bar Ilan UniversitySheba Medical CenterSheba Medical CenterBar Ilan UniversityBar Ilan UniversityBar Ilan UniversitySheba Medical CenterKing’s College London School of MedicineSheba Medical CenterTel Aviv UniversityBar Ilan UniversityChronic gastritis is characterized by gastric mucosal inflammation due to autoimmune responses or infection, frequently with Helicobacter pylori. Gastritis with H. pylori background can cause gastric mucosa-associated lymphoid tissue lymphoma (MALT-L), which sometimes further transforms into diffuse large B cell lymphoma (DLBCL). However, gastric DLBCL can also be initiated de novo. The mechanisms underlying transformation into DLBCL are not completely understood. <br/>We analyzed immunoglobulin repertoires and clonal trees to investigate whether and how immunoglobulin gene repertoires, clonal diversification and selection in gastritis, gastric MALT-L and DLBCL differ from each other and from normal responses. The two gastritis types (positive or negative for H. pylori) had similarly diverse repertoires. MALT-L dominant clones presented higher diversification and longer mutational histories compared with all other conditions. DLBCL dominant clones displayed lower clonal diversification, suggesting the transforming events are triggered by similar responses in different patients. These results are surprising, as we expected to find similarities between the dominant clones of gastritis and MALT-L and between those of MALT-L and DLBCL.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00264/fullGastritisDLBCLH. pylorisomatic hypermutationB-cellsrepertoire |
| spellingShingle | Miri eMichaeli Hilla eTabibian-Keissar Ginette eSchiby Gitit eShahaf Yishai ePickman Lena eHazanov Kinneret eRosenblatt Deborah K Dunn-Walters Iris eBarshack Iris eBarshack Ramit eMehr Immunoglobulin gene repertoire diversification and selection in the stomach – from gastritis to gastric lymphomas Frontiers in Immunology Gastritis DLBCL H. pylori somatic hypermutation B-cells repertoire |
| title | Immunoglobulin gene repertoire diversification and selection in the stomach – from gastritis to gastric lymphomas |
| title_full | Immunoglobulin gene repertoire diversification and selection in the stomach – from gastritis to gastric lymphomas |
| title_fullStr | Immunoglobulin gene repertoire diversification and selection in the stomach – from gastritis to gastric lymphomas |
| title_full_unstemmed | Immunoglobulin gene repertoire diversification and selection in the stomach – from gastritis to gastric lymphomas |
| title_short | Immunoglobulin gene repertoire diversification and selection in the stomach – from gastritis to gastric lymphomas |
| title_sort | immunoglobulin gene repertoire diversification and selection in the stomach from gastritis to gastric lymphomas |
| topic | Gastritis DLBCL H. pylori somatic hypermutation B-cells repertoire |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00264/full |
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