The Engagement Between MDSCs and Metastases: Partners in Crime
Tumor metastases represent the major cause of cancer-related mortality, confirming the urgent need to identify key molecular pathways and cell-associated networks during the early phases of the metastatic process to develop new strategies to either prevent or control distal cancer spread. Several da...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00165/full |
| _version_ | 1828877250845474816 |
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| author | Rosalinda Trovato Stefania Canè Varvara Petrova Silvia Sartoris Stefano Ugel Francesco De Sanctis |
| author_facet | Rosalinda Trovato Stefania Canè Varvara Petrova Silvia Sartoris Stefano Ugel Francesco De Sanctis |
| author_sort | Rosalinda Trovato |
| collection | DOAJ |
| description | Tumor metastases represent the major cause of cancer-related mortality, confirming the urgent need to identify key molecular pathways and cell-associated networks during the early phases of the metastatic process to develop new strategies to either prevent or control distal cancer spread. Several data revealed the ability of cancer cells to establish a favorable microenvironment, before their arrival in distant organs, by manipulating the cell composition and function of the new host tissue where cancer cells can survive and outgrow. This predetermined environment is termed “pre-metastatic niche” (pMN). pMN development requires that tumor-derived soluble factors, like cytokines, growth-factors and extracellular vesicles, genetically and epigenetically re-program not only resident cells (i.e., fibroblasts) but also non-resident cells such as bone marrow-derived cells. Indeed, by promoting an “emergency” myelopoiesis, cancer cells switch the steady state production of blood cells toward the generation of pro-tumor circulating myeloid cells defined as myeloid-derived suppressor cells (MDSCs) able to sustain tumor growth and dissemination. MDSCs are a heterogeneous subset of myeloid cells with immunosuppressive properties that sustain metastatic process. In this review, we discuss current understandings of how MDSCs shape and promote metastatic dissemination acting in each fundamental steps of cancer progression from primary tumor to metastatic disease. |
| first_indexed | 2024-12-13T08:36:44Z |
| format | Article |
| id | doaj.art-036f4e1f49024b24863f47eee33b7771 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T08:36:44Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-036f4e1f49024b24863f47eee33b77712022-12-21T23:53:37ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-02-011010.3389/fonc.2020.00165522252The Engagement Between MDSCs and Metastases: Partners in CrimeRosalinda TrovatoStefania CanèVarvara PetrovaSilvia SartorisStefano UgelFrancesco De SanctisTumor metastases represent the major cause of cancer-related mortality, confirming the urgent need to identify key molecular pathways and cell-associated networks during the early phases of the metastatic process to develop new strategies to either prevent or control distal cancer spread. Several data revealed the ability of cancer cells to establish a favorable microenvironment, before their arrival in distant organs, by manipulating the cell composition and function of the new host tissue where cancer cells can survive and outgrow. This predetermined environment is termed “pre-metastatic niche” (pMN). pMN development requires that tumor-derived soluble factors, like cytokines, growth-factors and extracellular vesicles, genetically and epigenetically re-program not only resident cells (i.e., fibroblasts) but also non-resident cells such as bone marrow-derived cells. Indeed, by promoting an “emergency” myelopoiesis, cancer cells switch the steady state production of blood cells toward the generation of pro-tumor circulating myeloid cells defined as myeloid-derived suppressor cells (MDSCs) able to sustain tumor growth and dissemination. MDSCs are a heterogeneous subset of myeloid cells with immunosuppressive properties that sustain metastatic process. In this review, we discuss current understandings of how MDSCs shape and promote metastatic dissemination acting in each fundamental steps of cancer progression from primary tumor to metastatic disease.https://www.frontiersin.org/article/10.3389/fonc.2020.00165/fullMDSCs (myeloid-derived suppressor cells)immunosuppressionmetastasesmetastatic processpre-metastatic niche |
| spellingShingle | Rosalinda Trovato Stefania Canè Varvara Petrova Silvia Sartoris Stefano Ugel Francesco De Sanctis The Engagement Between MDSCs and Metastases: Partners in Crime Frontiers in Oncology MDSCs (myeloid-derived suppressor cells) immunosuppression metastases metastatic process pre-metastatic niche |
| title | The Engagement Between MDSCs and Metastases: Partners in Crime |
| title_full | The Engagement Between MDSCs and Metastases: Partners in Crime |
| title_fullStr | The Engagement Between MDSCs and Metastases: Partners in Crime |
| title_full_unstemmed | The Engagement Between MDSCs and Metastases: Partners in Crime |
| title_short | The Engagement Between MDSCs and Metastases: Partners in Crime |
| title_sort | engagement between mdscs and metastases partners in crime |
| topic | MDSCs (myeloid-derived suppressor cells) immunosuppression metastases metastatic process pre-metastatic niche |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.00165/full |
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