Biochemical markers of atherosclerosis
This paper is a brief review of some lipid parameters and serum markers of inflammation in a view of their predictive relevance for the atherosclerotic disease. A discourse on the importance of measuring different lipids and lipoproteins, concentration of LDL particles and apolipoprotein levels is s...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Society of Medical Biochemists of Serbia, Belgrade
2008-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2008/1452-82580802148D.pdf |
| _version_ | 1818306410677534720 |
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| author | Đerić Mirjana Kojić-Damjanov Sunčica Čabarkapa Velibor Eremić Nevena |
| author_facet | Đerić Mirjana Kojić-Damjanov Sunčica Čabarkapa Velibor Eremić Nevena |
| author_sort | Đerić Mirjana |
| collection | DOAJ |
| description | This paper is a brief review of some lipid parameters and serum markers of inflammation in a view of their predictive relevance for the atherosclerotic disease. A discourse on the importance of measuring different lipids and lipoproteins, concentration of LDL particles and apolipoprotein levels is still underway. Also, the recommendations for apolipoprotein (a), phenotypization and other lipid markers have not yet been established. In recent years the recommendations imply simultaneous measuring of multiple markers and calculating the lipid index values such as lipid tetrad index (LTI), lipid pentad index (LPI) and atherogenic index of plasma (AIP). Several circulating markers of inflammation such as C-reactive protein, serum fibrinogen and elevated leukocyte number, are consistently associated with atherosclerosis. In spite of a lack of evidence on measuring the C-reactive protein in a wide population, the guidelines for its application in diagnostics and therapy of coronary heart disease were developed. Some proinflammatory cytokines, adhesion molecules and markers of leukocyte activation are promising markers, requiring, however, more detailed prospective evaluation. The question to be elucidated is if these inflammatory markers are directly involved in the pathogenic process. |
| first_indexed | 2024-12-13T06:42:03Z |
| format | Article |
| id | doaj.art-036fac4071534b12aae054a201550424 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-13T06:42:03Z |
| publishDate | 2008-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-036fac4071534b12aae054a2015504242022-12-21T23:56:23ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662008-01-012721481531452-82580802148DBiochemical markers of atherosclerosisĐerić Mirjana0Kojić-Damjanov Sunčica1Čabarkapa Velibor2https://orcid.org/0000-0001-7166-3379Eremić Nevena3Department of Laboratory Medicine, Clinical Center of Vojvodina, Novi SadDepartment of Laboratory Medicine, Clinical Center of Vojvodina, Novi SadDepartment of Laboratory Medicine, Clinical Center of Vojvodina, Novi SadDepartment of Laboratory Medicine, Clinical Center of Vojvodina, Novi SadThis paper is a brief review of some lipid parameters and serum markers of inflammation in a view of their predictive relevance for the atherosclerotic disease. A discourse on the importance of measuring different lipids and lipoproteins, concentration of LDL particles and apolipoprotein levels is still underway. Also, the recommendations for apolipoprotein (a), phenotypization and other lipid markers have not yet been established. In recent years the recommendations imply simultaneous measuring of multiple markers and calculating the lipid index values such as lipid tetrad index (LTI), lipid pentad index (LPI) and atherogenic index of plasma (AIP). Several circulating markers of inflammation such as C-reactive protein, serum fibrinogen and elevated leukocyte number, are consistently associated with atherosclerosis. In spite of a lack of evidence on measuring the C-reactive protein in a wide population, the guidelines for its application in diagnostics and therapy of coronary heart disease were developed. Some proinflammatory cytokines, adhesion molecules and markers of leukocyte activation are promising markers, requiring, however, more detailed prospective evaluation. The question to be elucidated is if these inflammatory markers are directly involved in the pathogenic process.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2008/1452-82580802148D.pdfatherosclerosisbiochemical markerslipidslipoproteins |
| spellingShingle | Đerić Mirjana Kojić-Damjanov Sunčica Čabarkapa Velibor Eremić Nevena Biochemical markers of atherosclerosis Journal of Medical Biochemistry atherosclerosis biochemical markers lipids lipoproteins |
| title | Biochemical markers of atherosclerosis |
| title_full | Biochemical markers of atherosclerosis |
| title_fullStr | Biochemical markers of atherosclerosis |
| title_full_unstemmed | Biochemical markers of atherosclerosis |
| title_short | Biochemical markers of atherosclerosis |
| title_sort | biochemical markers of atherosclerosis |
| topic | atherosclerosis biochemical markers lipids lipoproteins |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2008/1452-82580802148D.pdf |
| work_keys_str_mv | AT đericmirjana biochemicalmarkersofatherosclerosis AT kojicdamjanovsuncica biochemicalmarkersofatherosclerosis AT cabarkapavelibor biochemicalmarkersofatherosclerosis AT eremicnevena biochemicalmarkersofatherosclerosis |