Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia
New neurons are continuously generated from stem cells and integrated into the adult hippocampal circuitry, contributing to memory function. Several environmental, cellular, and molecular factors regulate the formation of new neurons, but the mechanisms that govern their incorporation into memory ci...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-03-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2019.00024/full |
| _version_ | 1818229430271606784 |
|---|---|
| author | Noelia Rodríguez-Iglesias Noelia Rodríguez-Iglesias Amanda Sierra Amanda Sierra Amanda Sierra Jorge Valero Jorge Valero Jorge Valero |
| author_facet | Noelia Rodríguez-Iglesias Noelia Rodríguez-Iglesias Amanda Sierra Amanda Sierra Amanda Sierra Jorge Valero Jorge Valero Jorge Valero |
| author_sort | Noelia Rodríguez-Iglesias |
| collection | DOAJ |
| description | New neurons are continuously generated from stem cells and integrated into the adult hippocampal circuitry, contributing to memory function. Several environmental, cellular, and molecular factors regulate the formation of new neurons, but the mechanisms that govern their incorporation into memory circuits are less explored. Herein we will focus on microglia, the resident immune cells of the CNS, which modulate the production of new neurons in the adult hippocampus and are also well suited to participate in their circuit integration. Microglia may contribute to the refinement of brain circuits during development and exert a role in physiological and pathological conditions by regulating axonal and dendritic growth; promoting the formation, elimination, and relocation of synapses; modulating excitatory synaptic maturation; and participating in functional synaptic plasticity. Importantly, microglia are able to sense subtle changes in their environment and may use this information to differently modulate hippocampal wiring, ultimately impacting on memory function. Deciphering the role of microglia in hippocampal circuitry constant rewiring will help to better understand the influence of microglia on memory function. |
| first_indexed | 2024-12-12T10:18:28Z |
| format | Article |
| id | doaj.art-036ffbc0e2734e4581eac8562ba9be65 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T10:18:28Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-036ffbc0e2734e4581eac8562ba9be652022-12-22T00:27:36ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2019-03-01710.3389/fcell.2019.00024439686Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of MicrogliaNoelia Rodríguez-Iglesias0Noelia Rodríguez-Iglesias1Amanda Sierra2Amanda Sierra3Amanda Sierra4Jorge Valero5Jorge Valero6Jorge Valero7Laboratory of Glial Cell Biology, Achucarro Basque Center for Neuroscience, Leioa, SpainDepartment of Neuroscience, University of the Basque Country UPV/EHU, Leioa, SpainLaboratory of Glial Cell Biology, Achucarro Basque Center for Neuroscience, Leioa, SpainDepartment of Neuroscience, University of the Basque Country UPV/EHU, Leioa, SpainIkerbasque Foundation, Bilbao, SpainLaboratory of Glial Cell Biology, Achucarro Basque Center for Neuroscience, Leioa, SpainDepartment of Neuroscience, University of the Basque Country UPV/EHU, Leioa, SpainIkerbasque Foundation, Bilbao, SpainNew neurons are continuously generated from stem cells and integrated into the adult hippocampal circuitry, contributing to memory function. Several environmental, cellular, and molecular factors regulate the formation of new neurons, but the mechanisms that govern their incorporation into memory circuits are less explored. Herein we will focus on microglia, the resident immune cells of the CNS, which modulate the production of new neurons in the adult hippocampus and are also well suited to participate in their circuit integration. Microglia may contribute to the refinement of brain circuits during development and exert a role in physiological and pathological conditions by regulating axonal and dendritic growth; promoting the formation, elimination, and relocation of synapses; modulating excitatory synaptic maturation; and participating in functional synaptic plasticity. Importantly, microglia are able to sense subtle changes in their environment and may use this information to differently modulate hippocampal wiring, ultimately impacting on memory function. Deciphering the role of microglia in hippocampal circuitry constant rewiring will help to better understand the influence of microglia on memory function.https://www.frontiersin.org/article/10.3389/fcell.2019.00024/fulladult hippocampal neurogenesishippocampal circuitmemorymicrogliarewiring |
| spellingShingle | Noelia Rodríguez-Iglesias Noelia Rodríguez-Iglesias Amanda Sierra Amanda Sierra Amanda Sierra Jorge Valero Jorge Valero Jorge Valero Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia Frontiers in Cell and Developmental Biology adult hippocampal neurogenesis hippocampal circuit memory microglia rewiring |
| title | Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia |
| title_full | Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia |
| title_fullStr | Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia |
| title_full_unstemmed | Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia |
| title_short | Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia |
| title_sort | rewiring of memory circuits connecting adult newborn neurons with the help of microglia |
| topic | adult hippocampal neurogenesis hippocampal circuit memory microglia rewiring |
| url | https://www.frontiersin.org/article/10.3389/fcell.2019.00024/full |
| work_keys_str_mv | AT noeliarodrigueziglesias rewiringofmemorycircuitsconnectingadultnewbornneuronswiththehelpofmicroglia AT noeliarodrigueziglesias rewiringofmemorycircuitsconnectingadultnewbornneuronswiththehelpofmicroglia AT amandasierra rewiringofmemorycircuitsconnectingadultnewbornneuronswiththehelpofmicroglia AT amandasierra rewiringofmemorycircuitsconnectingadultnewbornneuronswiththehelpofmicroglia AT amandasierra rewiringofmemorycircuitsconnectingadultnewbornneuronswiththehelpofmicroglia AT jorgevalero rewiringofmemorycircuitsconnectingadultnewbornneuronswiththehelpofmicroglia AT jorgevalero rewiringofmemorycircuitsconnectingadultnewbornneuronswiththehelpofmicroglia AT jorgevalero rewiringofmemorycircuitsconnectingadultnewbornneuronswiththehelpofmicroglia |