Contrast-Induced Nephropathy Following CT Scan and Its Associated Factors
Background and purpose: Contrast-induced nephropathy (CIN) as a common complication of administration of contrast media (CM) is a major source of hospital morbidity and mortality. The aim of this study was to determine the incidence of CIN after contrast-enhanced CT scan and identifying the related...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences
2019-12-01
|
| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-13256-en.html |
| _version_ | 1828055047322206208 |
|---|---|
| author | Hadi Majidi Ali Ghaemian Farnaz Godazandeh Fatemeh Espahbodi Ruholah Abdi Rezaali Mohammadpour |
| author_facet | Hadi Majidi Ali Ghaemian Farnaz Godazandeh Fatemeh Espahbodi Ruholah Abdi Rezaali Mohammadpour |
| author_sort | Hadi Majidi |
| collection | DOAJ |
| description | Background and purpose: Contrast-induced nephropathy (CIN) as a common complication of administration of contrast media (CM) is a major source of hospital morbidity and mortality. The aim of this study was to determine the incidence of CIN after contrast-enhanced CT scan and identifying the related risk factors.
Materials and methods: A cross-sectional study was carried out in 100 patients attending Sari Imam Khomeini Hospital who underwent contrast-enhanced CT scan in 2016. Predictors of CIN were evaluated in four general categories, including demographic variables, underlying diseases, concomitant medications, and laboratory findings. Data were analyzed in SPSS V20.
Results: In this study, increase in the concentration baseline serum creatinine of more than 25% or 0.5 mg/dl within 48 hours after the injection of contrast material was considered as an indicator of the incidence of CIN. Accordingly, the incidence rate was 7%. The incidence of CIN was significantly different in patients with and without hypertension (P= 0.028) and patients taking angiotensin II receptor blocking drugs (ARBs) (P= 0.019). Compared to creatinine, BUN and eGFR were both observed to be more accurate in predicting the incidence of CIN. BUN was found to have higher sensitivity and lower specificity while eGFR showed higher specificity and lower sensitivity.
Conclusion: In addition to hypertension and the use of ARBs as the major risk factors for the incidence of CIN, BUN was observed to be a better predictor for CIN than eGFR. Higher Efficacy of BUN could have been due to its larger size and therefore fewer laboratory errors. |
| first_indexed | 2024-04-10T20:32:25Z |
| format | Article |
| id | doaj.art-03714a2374064321a9007f188ee50f8f |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:32:25Z |
| publishDate | 2019-12-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-03714a2374064321a9007f188ee50f8f2023-01-25T05:07:55ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792019-12-0129179104116Contrast-Induced Nephropathy Following CT Scan and Its Associated FactorsHadi Majidi0Ali Ghaemian1Farnaz Godazandeh2Fatemeh Espahbodi3Ruholah Abdi4Rezaali Mohammadpour5 Assistant Professor, Department of Radiology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran Professor, Mazandaran Heart Center, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Department of Radiology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Department of Nephrology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Department of Radiology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Department of Biostatistics, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: Contrast-induced nephropathy (CIN) as a common complication of administration of contrast media (CM) is a major source of hospital morbidity and mortality. The aim of this study was to determine the incidence of CIN after contrast-enhanced CT scan and identifying the related risk factors. Materials and methods: A cross-sectional study was carried out in 100 patients attending Sari Imam Khomeini Hospital who underwent contrast-enhanced CT scan in 2016. Predictors of CIN were evaluated in four general categories, including demographic variables, underlying diseases, concomitant medications, and laboratory findings. Data were analyzed in SPSS V20. Results: In this study, increase in the concentration baseline serum creatinine of more than 25% or 0.5 mg/dl within 48 hours after the injection of contrast material was considered as an indicator of the incidence of CIN. Accordingly, the incidence rate was 7%. The incidence of CIN was significantly different in patients with and without hypertension (P= 0.028) and patients taking angiotensin II receptor blocking drugs (ARBs) (P= 0.019). Compared to creatinine, BUN and eGFR were both observed to be more accurate in predicting the incidence of CIN. BUN was found to have higher sensitivity and lower specificity while eGFR showed higher specificity and lower sensitivity. Conclusion: In addition to hypertension and the use of ARBs as the major risk factors for the incidence of CIN, BUN was observed to be a better predictor for CIN than eGFR. Higher Efficacy of BUN could have been due to its larger size and therefore fewer laboratory errors.http://jmums.mazums.ac.ir/article-1-13256-en.htmlcontrast induced nephropathyserum creatininect scan |
| spellingShingle | Hadi Majidi Ali Ghaemian Farnaz Godazandeh Fatemeh Espahbodi Ruholah Abdi Rezaali Mohammadpour Contrast-Induced Nephropathy Following CT Scan and Its Associated Factors Journal of Mazandaran University of Medical Sciences contrast induced nephropathy serum creatinine ct scan |
| title | Contrast-Induced Nephropathy Following CT Scan and
Its Associated Factors |
| title_full | Contrast-Induced Nephropathy Following CT Scan and
Its Associated Factors |
| title_fullStr | Contrast-Induced Nephropathy Following CT Scan and
Its Associated Factors |
| title_full_unstemmed | Contrast-Induced Nephropathy Following CT Scan and
Its Associated Factors |
| title_short | Contrast-Induced Nephropathy Following CT Scan and
Its Associated Factors |
| title_sort | contrast induced nephropathy following ct scan and its associated factors |
| topic | contrast induced nephropathy serum creatinine ct scan |
| url | http://jmums.mazums.ac.ir/article-1-13256-en.html |
| work_keys_str_mv | AT hadimajidi contrastinducednephropathyfollowingctscananditsassociatedfactors AT alighaemian contrastinducednephropathyfollowingctscananditsassociatedfactors AT farnazgodazandeh contrastinducednephropathyfollowingctscananditsassociatedfactors AT fatemehespahbodi contrastinducednephropathyfollowingctscananditsassociatedfactors AT ruholahabdi contrastinducednephropathyfollowingctscananditsassociatedfactors AT rezaalimohammadpour contrastinducednephropathyfollowingctscananditsassociatedfactors |