Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial
Virgin Coconut Oil (VCO) with potential fatty acid content has a strong antibacterial effect for drug and cosmetics. VCO was hydrolyzed as hydrolyzed VCO (HVCO) to increase its activity. This study aims to optimize VCO and HVCO microspheres. Examination was included fatty acid content, density, and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Advanced Pharmaceutical Technology & Research |
| Subjects: | |
| Online Access: | http://www.japtr.org/article.asp?issn=2231-4040;year=2022;volume=13;issue=3;spage=238;epage=242;aulast=Hariyadi |
| _version_ | 1811217764513218560 |
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| author | Dewi Melani Hariyadi Aldesra Fitri Sisunandar Sudarma Tutiek Purwanti Tristiana Erawati |
| author_facet | Dewi Melani Hariyadi Aldesra Fitri Sisunandar Sudarma Tutiek Purwanti Tristiana Erawati |
| author_sort | Dewi Melani Hariyadi |
| collection | DOAJ |
| description | Virgin Coconut Oil (VCO) with potential fatty acid content has a strong antibacterial effect for drug and cosmetics. VCO was hydrolyzed as hydrolyzed VCO (HVCO) to increase its activity. This study aims to optimize VCO and HVCO microspheres. Examination was included fatty acid content, density, and organoleptic. VCO and HVCO microspheres were characterized by yield, moisture content (MC), morphology, and size. Fatty acid content was done through gas chromatography mass spectrometry whereas for microspheres, effect of alginate concentration (1%–2%), and addition of poly ethylene glycol (PEG) were studied. VCO and HVCO microspheres formulas showed that an increase in polymer concentration, increasing yield, and improving MC. The most optimal 2% alginate with the addition of PEG increased yield up to 59% and reduced size. F4 microspheres resulted the highest yield, low MC, and high fatty acids. Morphology was spherical and smooth with small size. Optimization of HVCO microspheres showed its potential which recommend for antibacterial and antifungal activity. |
| first_indexed | 2024-04-12T06:59:55Z |
| format | Article |
| id | doaj.art-03716a704131404c88ab66debaa261c9 |
| institution | Directory Open Access Journal |
| issn | 2231-4040 0976-2094 |
| language | English |
| last_indexed | 2024-04-12T06:59:55Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Advanced Pharmaceutical Technology & Research |
| spelling | doaj.art-03716a704131404c88ab66debaa261c92022-12-22T03:43:01ZengWolters Kluwer Medknow PublicationsJournal of Advanced Pharmaceutical Technology & Research2231-40400976-20942022-01-0113323824210.4103/japtr.japtr_99_22Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobialDewi Melani HariyadiAldesra FitriSisunandar SudarmaTutiek PurwantiTristiana ErawatiVirgin Coconut Oil (VCO) with potential fatty acid content has a strong antibacterial effect for drug and cosmetics. VCO was hydrolyzed as hydrolyzed VCO (HVCO) to increase its activity. This study aims to optimize VCO and HVCO microspheres. Examination was included fatty acid content, density, and organoleptic. VCO and HVCO microspheres were characterized by yield, moisture content (MC), morphology, and size. Fatty acid content was done through gas chromatography mass spectrometry whereas for microspheres, effect of alginate concentration (1%–2%), and addition of poly ethylene glycol (PEG) were studied. VCO and HVCO microspheres formulas showed that an increase in polymer concentration, increasing yield, and improving MC. The most optimal 2% alginate with the addition of PEG increased yield up to 59% and reduced size. F4 microspheres resulted the highest yield, low MC, and high fatty acids. Morphology was spherical and smooth with small size. Optimization of HVCO microspheres showed its potential which recommend for antibacterial and antifungal activity.http://www.japtr.org/article.asp?issn=2231-4040;year=2022;volume=13;issue=3;spage=238;epage=242;aulast=Hariyadiantibacterialantifungalhydrolyzed vcomicrospheresvco |
| spellingShingle | Dewi Melani Hariyadi Aldesra Fitri Sisunandar Sudarma Tutiek Purwanti Tristiana Erawati Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial Journal of Advanced Pharmaceutical Technology & Research antibacterial antifungal hydrolyzed vco microspheres vco |
| title | Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial |
| title_full | Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial |
| title_fullStr | Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial |
| title_full_unstemmed | Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial |
| title_short | Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial |
| title_sort | optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial |
| topic | antibacterial antifungal hydrolyzed vco microspheres vco |
| url | http://www.japtr.org/article.asp?issn=2231-4040;year=2022;volume=13;issue=3;spage=238;epage=242;aulast=Hariyadi |
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