Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma
Background: Urothelial carcinoma (UC), also known as transitional cell carcinoma, is the most common malignant tumor of the canine urinary bladder and represents a model for studying human bladder cancer. However, the existing literature has limited data on the clinicopathological characteristics of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tripoli University
2021-10-01
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| Series: | Open Veterinary Journal |
| Subjects: | |
| Online Access: | https://www.openveterinaryjournal.com/OVJ-2021-04-070%20V.M.%20Govoni%20et%20al.pdf |
| _version_ | 1818578269670211584 |
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| author | Verônica M. Govoni Claudio Pigoli Felipe Augusto R. Sueiro Fernanda Zuliani Thayná O. da Silva Juliany G. Quitzan Renee Laufer-Amorim Valeria Grieco Carlos Eduardo Fonseca-Alves |
| author_facet | Verônica M. Govoni Claudio Pigoli Felipe Augusto R. Sueiro Fernanda Zuliani Thayná O. da Silva Juliany G. Quitzan Renee Laufer-Amorim Valeria Grieco Carlos Eduardo Fonseca-Alves |
| author_sort | Verônica M. Govoni |
| collection | DOAJ |
| description | Background: Urothelial carcinoma (UC), also known as transitional cell carcinoma, is the most common malignant tumor of the canine urinary bladder and represents a model for studying human bladder cancer. However, the existing literature has limited data on the clinicopathological characteristics of these tumors and their prognostic value.
Aim: The aim of this study was to evaluate such factors, correlating them with follow-up, in a group of 32 dogs with bladder UC.
Methods: Clinical data of these cases, submitted to São Paulo State University (UNESP) and VetPat Private Laboratory (São Paulo/Brazil), were recorded between January 2000 and November 2019. For each case, formalin-fixed and paraffin-embedded sections were stained with hematoxylin-eosin and histologically evaluated. Survival analysis was performed, and prognostic value of the presence of lymphatic invasion and the treatment used was determined.
Results: Dogs with neoplastic lymphatic vessel invasion had lower overall survival compared with those without lymphatic invasion, and dogs that received vinblastine in addition to surgery had higher global survival when compared with animals that received carboplatin in addition to surgery.
Conclusions: The results obtained show the importance of further studies regarding the prognostic value of the two factors demonstrated as potential survival predictors, especially the lymphatic vessel invasion. |
| first_indexed | 2024-12-16T06:43:08Z |
| format | Article |
| id | doaj.art-0371b1d7f0d3403bbb4ec74af8e438c5 |
| institution | Directory Open Access Journal |
| issn | 2226-4485 2218-6050 |
| language | English |
| last_indexed | 2024-12-16T06:43:08Z |
| publishDate | 2021-10-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj.art-0371b1d7f0d3403bbb4ec74af8e438c52022-12-21T22:40:38ZengTripoli UniversityOpen Veterinary Journal2226-44852218-60502021-10-0111453554310.5455/OVJ.2021.v11.i4.3Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinomaVerônica M. Govoni0Claudio Pigoli1Felipe Augusto R. Sueiro2Fernanda Zuliani3Thayná O. da Silva4Juliany G. Quitzan5Renee Laufer-Amorim6Valeria Grieco7Carlos Eduardo Fonseca-Alves8Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Sao Paulo State University – UNESP, Botucatu, SP, 18618-681, BrazilLaboratorio di Istologia, Sede Territoriale di Milano, Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia-Romagna (IZSLER), Milan, 20133, Italy and Department of Veterinary Medicine, University of Milan, Milan, ItalyVetPat Laboratory, Campinas-SP, 13073-022, BrazilDepartment of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Sao Paulo State University – UNESP, Botucatu, SP, 18618-681, BrazilDepartment of Veterinary Clinic, School of Veterinary Medicine and Animal Science, Sao Paulo State University – UNESP, Botucatu, SP, 18618-681, BrazilDepartment of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Sao Paulo State University – UNESP, Botucatu, SP, 18618-681, BrazilDepartment of Veterinary Clinic, School of Veterinary Medicine and Animal Science, Sao Paulo State University – UNESP, Botucatu, SP, 18618-681, BrazilDepartment of Veterinary Medicine, University of Milan, Milan, ItalyDepartment of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Sao Paulo State University – UNESP, Botucatu, SP, 18618-681, Brazil and Institute of Health Sciences, Paulista University – UNIP, Bauru-SP, 17048-290, BrazilBackground: Urothelial carcinoma (UC), also known as transitional cell carcinoma, is the most common malignant tumor of the canine urinary bladder and represents a model for studying human bladder cancer. However, the existing literature has limited data on the clinicopathological characteristics of these tumors and their prognostic value. Aim: The aim of this study was to evaluate such factors, correlating them with follow-up, in a group of 32 dogs with bladder UC. Methods: Clinical data of these cases, submitted to São Paulo State University (UNESP) and VetPat Private Laboratory (São Paulo/Brazil), were recorded between January 2000 and November 2019. For each case, formalin-fixed and paraffin-embedded sections were stained with hematoxylin-eosin and histologically evaluated. Survival analysis was performed, and prognostic value of the presence of lymphatic invasion and the treatment used was determined. Results: Dogs with neoplastic lymphatic vessel invasion had lower overall survival compared with those without lymphatic invasion, and dogs that received vinblastine in addition to surgery had higher global survival when compared with animals that received carboplatin in addition to surgery. Conclusions: The results obtained show the importance of further studies regarding the prognostic value of the two factors demonstrated as potential survival predictors, especially the lymphatic vessel invasion.https://www.openveterinaryjournal.com/OVJ-2021-04-070%20V.M.%20Govoni%20et%20al.pdfdogtransitional cell carcinomaprognosisbladder cancer |
| spellingShingle | Verônica M. Govoni Claudio Pigoli Felipe Augusto R. Sueiro Fernanda Zuliani Thayná O. da Silva Juliany G. Quitzan Renee Laufer-Amorim Valeria Grieco Carlos Eduardo Fonseca-Alves Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma Open Veterinary Journal dog transitional cell carcinoma prognosis bladder cancer |
| title | Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma |
| title_full | Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma |
| title_fullStr | Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma |
| title_full_unstemmed | Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma |
| title_short | Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma |
| title_sort | lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma |
| topic | dog transitional cell carcinoma prognosis bladder cancer |
| url | https://www.openveterinaryjournal.com/OVJ-2021-04-070%20V.M.%20Govoni%20et%20al.pdf |
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