Neuroprotective effect of fucoidan by regulating gut-microbiota-brain axis in alcohol withdrawal mice
The aim of the study was to detect the neuroprotective activity of fucoidan in alcohol exposure and withdrawal mice and the underlying mechanisms. C57BL/6J mice were used to establish the murine model of chronic alcoholism and withdrawal over 10 weeks of alcohol exposure. After fucoidan treatment, t...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464621003753 |
| _version_ | 1818664593160929280 |
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| author | Meilan Xue Xiangyun Teng Hui Liang Jinglan Zhao Yushan Jiang Xia Qiu Zheng Zhang Zhongqian Pei Nan Zhang Yimin Qin |
| author_facet | Meilan Xue Xiangyun Teng Hui Liang Jinglan Zhao Yushan Jiang Xia Qiu Zheng Zhang Zhongqian Pei Nan Zhang Yimin Qin |
| author_sort | Meilan Xue |
| collection | DOAJ |
| description | The aim of the study was to detect the neuroprotective activity of fucoidan in alcohol exposure and withdrawal mice and the underlying mechanisms. C57BL/6J mice were used to establish the murine model of chronic alcoholism and withdrawal over 10 weeks of alcohol exposure. After fucoidan treatment, the depression-like behaviors in mice with alcoholism were improved, and 5-hydroxytryptamine and brain derived neurotrophic factor levels were increased both in serum and brain tissues. Fucoidan treatment attenuated the increase of lipopolysaccharide induced by alcohol, and decreased tumor necrosis factor-α and interleukin-1β levels. In hippocampus fucoidan inhibited microglia cell activation, and down-regulated the levels of Toll-like receptor 4 and its downstream protein factors. In addition, fucoidan regulated the structure of gut flora and made the composition of microbiota more similar to that of the normal control mice with increased abundances of Prevotella and Alloprevotella. Oral administration of fucoidan could alleviate the depression-like behaviors of mice with alcoholism through the gut-microbiota-brain axis. |
| first_indexed | 2024-12-17T05:35:12Z |
| format | Article |
| id | doaj.art-0374aabe57124013a8b23398c22b27e0 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T05:35:12Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-0374aabe57124013a8b23398c22b27e02022-12-21T22:01:38ZengElsevierJournal of Functional Foods1756-46462021-11-0186104726Neuroprotective effect of fucoidan by regulating gut-microbiota-brain axis in alcohol withdrawal miceMeilan Xue0Xiangyun Teng1Hui Liang2Jinglan Zhao3Yushan Jiang4Xia Qiu5Zheng Zhang6Zhongqian Pei7Nan Zhang8Yimin Qin9Department of Biochemistry and Molecular Biology, Basic Medical College, Qingdao University of Medicine, 308 Ningxia Road, Qingdao 266071, ChinaDepartment of Human Nutrition, College of Public Health, Qingdao University of Medicine, 308 Ningxia Road, Qingdao 266071, ChinaDepartment of Human Nutrition, College of Public Health, Qingdao University of Medicine, 308 Ningxia Road, Qingdao 266071, China; Corresponding author.Department of Cardiothoracic Surgery of Qingdao Center Medical Group, Qingdao 266042, ChinaDepartment of Human Nutrition, College of Public Health, Qingdao University of Medicine, 308 Ningxia Road, Qingdao 266071, ChinaState Key Laboratory of Bioactive Seaweed Substances, Qingdao Brightmoon Seaweed Group Co.Ltd., 777 Mingyue Road, Huangdao District, Qingdao 266400, ChinaDepartment of Biochemistry and Molecular Biology, Basic Medical College, Qingdao University of Medicine, 308 Ningxia Road, Qingdao 266071, ChinaDepartment of Biochemistry and Molecular Biology, Basic Medical College, Qingdao University of Medicine, 308 Ningxia Road, Qingdao 266071, ChinaDepartment of Biochemistry and Molecular Biology, Basic Medical College, Qingdao University of Medicine, 308 Ningxia Road, Qingdao 266071, ChinaState Key Laboratory of Bioactive Seaweed Substances, Qingdao Brightmoon Seaweed Group Co.Ltd., 777 Mingyue Road, Huangdao District, Qingdao 266400, ChinaThe aim of the study was to detect the neuroprotective activity of fucoidan in alcohol exposure and withdrawal mice and the underlying mechanisms. C57BL/6J mice were used to establish the murine model of chronic alcoholism and withdrawal over 10 weeks of alcohol exposure. After fucoidan treatment, the depression-like behaviors in mice with alcoholism were improved, and 5-hydroxytryptamine and brain derived neurotrophic factor levels were increased both in serum and brain tissues. Fucoidan treatment attenuated the increase of lipopolysaccharide induced by alcohol, and decreased tumor necrosis factor-α and interleukin-1β levels. In hippocampus fucoidan inhibited microglia cell activation, and down-regulated the levels of Toll-like receptor 4 and its downstream protein factors. In addition, fucoidan regulated the structure of gut flora and made the composition of microbiota more similar to that of the normal control mice with increased abundances of Prevotella and Alloprevotella. Oral administration of fucoidan could alleviate the depression-like behaviors of mice with alcoholism through the gut-microbiota-brain axis.http://www.sciencedirect.com/science/article/pii/S1756464621003753FucoidanAlcohol withdrawalDepression-like behaviorsGut-microbiota-brain axisMice |
| spellingShingle | Meilan Xue Xiangyun Teng Hui Liang Jinglan Zhao Yushan Jiang Xia Qiu Zheng Zhang Zhongqian Pei Nan Zhang Yimin Qin Neuroprotective effect of fucoidan by regulating gut-microbiota-brain axis in alcohol withdrawal mice Journal of Functional Foods Fucoidan Alcohol withdrawal Depression-like behaviors Gut-microbiota-brain axis Mice |
| title | Neuroprotective effect of fucoidan by regulating gut-microbiota-brain axis in alcohol withdrawal mice |
| title_full | Neuroprotective effect of fucoidan by regulating gut-microbiota-brain axis in alcohol withdrawal mice |
| title_fullStr | Neuroprotective effect of fucoidan by regulating gut-microbiota-brain axis in alcohol withdrawal mice |
| title_full_unstemmed | Neuroprotective effect of fucoidan by regulating gut-microbiota-brain axis in alcohol withdrawal mice |
| title_short | Neuroprotective effect of fucoidan by regulating gut-microbiota-brain axis in alcohol withdrawal mice |
| title_sort | neuroprotective effect of fucoidan by regulating gut microbiota brain axis in alcohol withdrawal mice |
| topic | Fucoidan Alcohol withdrawal Depression-like behaviors Gut-microbiota-brain axis Mice |
| url | http://www.sciencedirect.com/science/article/pii/S1756464621003753 |
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