Giant Rectal Gastrointestinal Stromal Tumors: A Report of Two Cases
Giant gastrointestinal stromal tumors (GISTs) of the rectum are rare and often difficult to remove surgically. At the time metastases are found, GISTs are considered to be incurable and until recently no adequate therapy was of any value for these patients. Recently, imatinib was introduced: a signa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2008-03-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/119317 |
| _version_ | 1819133371272396800 |
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| author | C. Dickhoff R.J. Leguit J.F.M. Slors W.L. Vervenne W.A. Bemelman |
| author_facet | C. Dickhoff R.J. Leguit J.F.M. Slors W.L. Vervenne W.A. Bemelman |
| author_sort | C. Dickhoff |
| collection | DOAJ |
| description | Giant gastrointestinal stromal tumors (GISTs) of the rectum are rare and often difficult to remove surgically. At the time metastases are found, GISTs are considered to be incurable and until recently no adequate therapy was of any value for these patients. Recently, imatinib was introduced: a signal transducing inhibitor acting specifically on the KIT-tyrosine kinase, which can be used to downsize giant GIST (neo-adjuvant) before surgery or induce stable disease in case of metastases with few minor side-effects. Two patients with giant rectal GIST are presented, one of which was treated before the imatinib era, the other when imatinib was available. |
| first_indexed | 2024-12-22T09:46:14Z |
| format | Article |
| id | doaj.art-03758b68e2a04224a1ec597423baef37 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-12-22T09:46:14Z |
| publishDate | 2008-03-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-03758b68e2a04224a1ec597423baef372022-12-21T18:30:32ZengKarger PublishersCase Reports in Gastroenterology1662-06312008-03-0121545910.1159/000119317119317Giant Rectal Gastrointestinal Stromal Tumors: A Report of Two CasesC. DickhoffR.J. LeguitJ.F.M. SlorsW.L. VervenneW.A. BemelmanGiant gastrointestinal stromal tumors (GISTs) of the rectum are rare and often difficult to remove surgically. At the time metastases are found, GISTs are considered to be incurable and until recently no adequate therapy was of any value for these patients. Recently, imatinib was introduced: a signal transducing inhibitor acting specifically on the KIT-tyrosine kinase, which can be used to downsize giant GIST (neo-adjuvant) before surgery or induce stable disease in case of metastases with few minor side-effects. Two patients with giant rectal GIST are presented, one of which was treated before the imatinib era, the other when imatinib was available.http://www.karger.com/Article/FullText/119317Gastrointestinal stromal tumorImatinibRectalNeo-adjuvant |
| spellingShingle | C. Dickhoff R.J. Leguit J.F.M. Slors W.L. Vervenne W.A. Bemelman Giant Rectal Gastrointestinal Stromal Tumors: A Report of Two Cases Case Reports in Gastroenterology Gastrointestinal stromal tumor Imatinib Rectal Neo-adjuvant |
| title | Giant Rectal Gastrointestinal Stromal Tumors: A Report of Two Cases |
| title_full | Giant Rectal Gastrointestinal Stromal Tumors: A Report of Two Cases |
| title_fullStr | Giant Rectal Gastrointestinal Stromal Tumors: A Report of Two Cases |
| title_full_unstemmed | Giant Rectal Gastrointestinal Stromal Tumors: A Report of Two Cases |
| title_short | Giant Rectal Gastrointestinal Stromal Tumors: A Report of Two Cases |
| title_sort | giant rectal gastrointestinal stromal tumors a report of two cases |
| topic | Gastrointestinal stromal tumor Imatinib Rectal Neo-adjuvant |
| url | http://www.karger.com/Article/FullText/119317 |
| work_keys_str_mv | AT cdickhoff giantrectalgastrointestinalstromaltumorsareportoftwocases AT rjleguit giantrectalgastrointestinalstromaltumorsareportoftwocases AT jfmslors giantrectalgastrointestinalstromaltumorsareportoftwocases AT wlvervenne giantrectalgastrointestinalstromaltumorsareportoftwocases AT wabemelman giantrectalgastrointestinalstromaltumorsareportoftwocases |